Bay Biosciences provides high quality, clinical grade serum (sera), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples from treatment-naive patients diagnosed with Crohn’s Disease. The serum (sera), plasma and PBMC biofluid samples are processed from Crohn’s disease patient’s fresh whole-blood from unique untreated patients diagnosed with Crohn’s disease.
Detailed clinical data, histology, pathology annotations including patient’s corresponding diagnostic test values associated with the serum (sera), plasma and PBMC biofluid samples are provided to a valued pharmaceutical customer for diagnostics, research, development and drug discovery.
Crohn’s Disease Overview
Crohn’s disease is a type of inflammatory bowel disease (IBD). It causes inflammation of the digestive tract, which can lead to abdominal pain, severe diarrhea, fatigue, weight loss and malnutrition. Inflammation caused by Crohn’s disease can involve different areas of the digestive tract in different people. This inflammation often spreads into the deeper layers of the bowel. Researchers aren’t sure how Crohn’s disease begins, who is most likely to develop it, or how to best manage it. Despite major treatment advances in the last several decades, no cure is available yet.
IBD affects an estimated 3 million Americans. Men and women are equally likely to be affected by Crohn’s disease. Crohn’s disease can be both painful and debilitating, and sometimes may lead to life-threatening complications. While there’s no known cure for Crohn’s disease, therapies can greatly reduce its signs and symptoms and even bring about long-term remission and healing of inflammation. With treatment, many patients with Crohn’s disease are able to function well. Crohn’s disease most commonly occurs in the small intestine and the colon. It can affect any part of the gastrointestinal (GI) tract, from the mouth to the anus. It can involve some parts of the GI tract and skip the other parts. The range of severity for Crohn’s is mild to debilitating. Symptoms vary and can change over time. In severe cases, the disease can lead to life-threatening flares and complications.
Causes of Crohn’s Disease
Exact causes of Crohn’s disease are unknown, however, the following factors may influence developing Crohn’s disease:
- Immune system
- Genes
- Environment
According to Crohn’s and Colitis Foundation 28% percent of patients with Crohn’s disease have a first-degree relative, such as a parent, child, or sibling, who also has the disease. Certain factors can affect the severity of Crohn’s disease symptoms, these include:
- Smoking
- Age
- Whether or not the rectum is involved
- Length of time you’ve had the disease
Patients with Crohn’s are also more likely to develop intestinal infections from bacteria, viruses, parasites, and fungi. This can affect the severity of symptoms and create complications. Crohn’s disease and its treatments can also affect the immune system, making these types of infections worse. Yeast infections are common in Crohn’s and can affect both the lungs and the intestinal tract. It’s important that these infections are diagnosed and properly treated with antifungal medications to prevent further complications.
In Crohn’s disease, any part of the small or large intestine can be involved, and it may be continuous or may involve multiple segments. In some patients, the disease is confined to the colon, which is part of the large intestine. Signs and symptoms of Crohn’s disease can range from mild to severe. They usually develop gradually, but sometimes will come on suddenly, without warning. Crohn’s disease patients may also have periods of time when they have no signs or symptoms (remission).
Signs and Symptoms of Crohn’s Disease
Following are the signs and symptoms of active Crohn’s disease:
- Diarrhea
- Fever
- Fatigue
- Abdominal pain and cramping
- Loss of appetite
- Weight loss
- Blood in the stool
- Mouth sores
- Reduced appetite and weight loss
- Pain or drainage near or around the anus due to inflammation from a tunnel into the skin (fistula)
- Feeling as if your bowels aren’t empty after a bowel movement (Tenesmus)
- Frequent need for bowel movements (Fecal incontinence)
The symptoms may become more severe as the Crohn’s disease progresses, more serious symptoms may include:
- Perianal fistula which causes pain and drainage near your anus
- Ulcers that may occur anywhere from the mouth to the anus
- Inflammation of the joints and skin
- Shortness of breath or decreased ability to exercise due to anemia
Other signs and symptoms
Patients with severe Crohn’s disease may also experience:
- Inflammation of eyes
- Inflammation of the liver or bile ducts
- Kidney stones
- Iron deficiency (anemia)
- Delayed growth or sexual development, in children
Early detection and diagnosis of Crohn’s disease can help avoid severe complications and allow patients to begin treatment early.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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