Cutaneous B-Cell Lymphoma Samples

Bay Biosciences provides high-quality, matched fresh frozen sera (serum),  plasma, and peripheral blood mononuclear cells (PBMC) bio-fluids from patients diagnosed with cutaneous B-Cell Lymphoma.

Moreover, the sera (serum), plasma and PBMC bio-fluids are processed from cutaneous B-Cell Lymphoma patient’s blood using customized collection and processing protocols.

In addition, the matched bio-fluids are collected from unique patients with cutaneous B-Cell Lymphoma and are provided to a valued pharmaceutical customer for research, development and drug discovery.

 

Cutaneous B-Cell Lymphoma Overview

Cutaneous B-cell lymphoma (CBCL) is a rare type of cancer. Consequently, it begins in the white blood cells and attacks the skin. Lymphomas are tumors of the lymph nodes and lymphatic system. Primary cutaneous lymphomas occur in the skin with no evidence of extracutaneous disease at the time of diagnosis. Cutaneous lymphomas represent a unique group of lymphomas and are the second most frequent extranodal lymphomas.

 Extranodal lymphomas are tumors that occur in organs or tissues outside of the lymphatic system. They can be defined as lymphoproliferative skin infiltrates of T-cell, B-cell, or natural killer cell lineage. Moreover, it primarily occur in and remain confined to the skin in most patients. However, without detectable extracutaneous manifestations at diagnosis.

Cutaneous B-cell lymphoma begins in the B cells lymphocytes which are a type of disease-fighting white blood cells. Cutaneous B-cell lymphomas are a malignant proliferation of lymphocytes of the B-cell type. Mutation occurring at different points in B cell development leads to different forms of lymphoma. B-cell lymphomas account for the majority of nodal lymphomas. Whereas primary cutaneous B-cell lymphomas (CBCLs) represent 20-25% of all cutaneous lymphomas.

Types of Cutaneous B-Cell Lymphoma

Following are different types of cutaneous B-cell lymphoma:

  • Primary cutaneous follicle center lymphoma: These skin lymphomas develop slowly over months or years. And usually appear on the head, neck, or torso of the body as a red-brown bumpy rash or nodules.
  • Primary cutaneous marginal zone B-cell lymphoma: This slow-growing lymphoma is the second most common form of CBCL. And appears as pink or red lesions, nodules, and/ or tumors, most commonly found on the torso or arms.
  • Primary cutaneous diffuse large B-cell lymphoma, leg type: This lymphoma usually appears as solitary or multiple tumor nodules on the legs, arms, and/or torso and is less common but usually more aggressive (fast-growing), developing over weeks or months.
  • Intravascular diffuse large B-cell lymphoma: This describes a group of very rare lymphomas, including intravascular large B-cell lymphoma, T-cell–rich large B-cell lymphoma, plasmablastic lymphoma, and anaplastic B-cell lymphoma that usually appear on the head, torso, and extremities.

Cutaneous B-cell lymphoma sometimes form as a nodule under the skin that may be the same color as your skin or may appear pink or purple in color.

Signs and Symptoms of Cutaneous B-Cell Lymphoma

The prominent signs and symptom of cutaneous B-Cell lymphoma (CBCL) are lumps on the skin. The lumps usually appear as small, raised, solid areas of skin that look like small pimples. These are known as papules and may develop into thickened, flat areas or larger lumps can be deep red or purplish and are called nodules or tumors. Sometimes these lumps break down and ulcerate and may become infected. Papules or nodules appear most commonly on the head, neck, back or legs.

Other symptoms of Cutaneous B-cell lymphoma could include:

  • Swollen lymph nodes in the armpits, groin and neck
  • Night sweats
  • Persistent fever
  • Unexplained weight loss

Diagnosis of Cutaneous B-Cell Lymphoma

Following are the typical procedures done to diagnose Cutaneous B-cell lymphoma (CBCL):

  • A complete physical exam, including a thorough skin exam.
  • A skin and/or lymph node biopsy which is a removal of a small piece of tissue from the affected area for examination under the microscope by a pathologist.
  • Blood tests 
  • And imaging tests such as CT scan (computerized axial tomography) and/or PET (positron emission tomography) scans.

When a skin biopsy shows B-cell lymphoma it is important to make sure that the lymphoma is truly coming from the skin, and not from a systemic lymphoma that has spread to the skin. Is also important that any diagnosis of Cutaneous B-cell lymphoma (CBCL) is confirmed by a pathologist who has expertise in diagnosing cutaneous lymphomas.

 

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC) and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, researchers find patient’s data extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

  • Firstly, Peripheral whole-blood
  • Secondly, Amniotic fluid
  • Third, Bronchoalveolar lavage fluid (BAL)
  • Moreover, Sputum
  • Furthermore, Pleural effusion
  • Next, Cerebrospinal fluid (CSF)
  • Also, Serum (sera)
  • Likewise, Plasma
  • In addition, Peripheral blood mononuclear cells (PBMC)
  • For example, Saliva
  • Also, Buffy coat
  • Moreover, Urine
  • Furthermore, stool samples
  • Next, Aqueous humor
  • Likewise, Vitreous humor
  • Lastly, Kidney stones (renal calculi)
  • Finally, Other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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