Burkitt’s Lymphoma Samples for Research

Bay Biosciences provides high-quality, biopsy tumor tissue samples, FFPE tissue blocks with matched sera (serum),  plasma, and peripheral blood mononuclear cells (PBMC) bio-fluids from patients diagnosed with Burkitt’s lymphoma.

Moreover, the sera (serum), plasma and PBMC bio-fluids are processed from Burkitt’s lymphoma patient’s peripheral whole-blood using customized collection and processing protocols.

In addition, the matched bio-fluids are collected from unique patients with Burkitt’s lymphoma and are provided to a valued pharmaceutical customer for research, development and drug discovery.

 

Burkitt’s Lymphoma Overview

In fact, Burkitt’s lymphoma is a type of non-Hodgkin’s lymphoma in which cancer starts in immune cells called B-cells. Moreover, Burkitt’s lymphoma is a rare, fast-growing, and aggressive tumor, and it is associated with impaired immunity. Additionally, non-Hodgkin’s lymphoma is a type of cancer of the lymphatic system, which helps your body fight infections.

Furthermore, Burkitt’s lymphoma is named after British surgeon Denis Burkitt, who identified this rare disease in 1956 among children in Africa. Notably, in Africa, Burkitt’s lymphoma is common in young children who also have malaria and Epstein-Barr, the virus that causes infectious mononucleosis. One reason may be that the malaria weakens the immune system’s response to Epstein-Barr, thereby allowing it to change infected B-cells into cancerous cells. Interestingly, about 98% of African cases are associated with Epstein-Barr infection.

Additionally, Burkitt’s lymphoma is also seen elsewhere, including the United States. Specifically, outside of Africa, Burkitt’s lymphoma is most likely to develop in patients who have a compromised immune system. In fact, Burkitt’s lymphoma is rare in the United States; about 1,200 patients are diagnosed each year, and the majority of the patients are over the age of 40. Moreover, Burkitt’s lymphoma is especially likely to develop in people infected with the human immune virus (HIV). the virus that causes AIDS.

Therefore, before highly active antiretroviral therapy (HAART) became a widespread treatment for HIV/AIDS  the incidence of Burkitt’s lymphoma was estimated to be 1,000 times higher in HIV-positive people than in the general population.

Types of Burkitt’s Lymphoma

According to the World Health Organization (WHO) classification, there are three types of Burkitt’s lymphoma:

  • Endemic (African): Endemic Burkitt lymphoma primarily affects African children ages 4 to 7 and is more commonly found in boys, two times more than the girls.
  • Sporadic (non-African): Sporadic Burkitt’s lymphoma occurs all over the world. Globally, it accounts for 1 to 2 percent of adult lymphoma cases. In the United States and Western Europe, it accounts for up to 40 percent of pediatric lymphoma cases.
  • Immunodeficiency-associated: This variant of Burkitt lymphoma is most common in people with HIV/AIDS. It accounts for 30 to 40 percentof non-Hodgkin lymphoma in HIV patients and may be an AIDS-defining disease. It can also occur in patients with congenital conditions that cause immune deficiency and in organ transplant patients who take immunosuppressive drugs.

Compared to the endemic type, the incidence of Epstein-Barr infection is considerably lower in the other two types of Burkitt’s lymphoma. In the sporadic disease, Epstein-Barr occurs in about 20% of the patients. With the immunodeficiency-associated type, it occurs in about 30 to 40 percent of patients. So, the association of Epstein-Barr virus with these two types of Burkitt’s lymphoma is unclear.

 

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC) and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, researchers find patient’s data extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

  • Firstly, Peripheral whole-blood
  • Secondly, Amniotic fluid
  • Third, Bronchoalveolar lavage fluid (BAL)
  • Moreover, Sputum
  • Furthermore, Pleural effusion
  • Next, Cerebrospinal fluid (CSF)
  • Also, Serum (sera)
  • Likewise, Plasma
  • In addition, Peripheral blood mononuclear cells (PBMC)
  • For example, Saliva
  • Also, Buffy coat
  • Moreover, Urine
  • Furthermore, stool samples
  • Next, Aqueous humor
  • Likewise, Vitreous humor
  • Lastly, Kidney stones (renal calculi)
  • Finally, Other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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