Bay Biosciences provides high quality, clinical grade bio-samples, skin biopsy tissue samples, FFPE tissue blocks, sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid specimens from patients diagnosed with Dermatomyositis disease. The PBMC, sera (serum) and plasma samples are processed from patient’s peripheral whole-blood using customized processing protocols.
The human Dermatomyositis bio-specimens are collected from unique patients diagnosed with Dermatomyositis disease and provided to a valued pharmaceutical customer for research, development and drug discovery.
Dermatomyositis Overview
Dermatomyositis is a rare inflammatory autoimmune disease, a condition that causes distinctive skin rash and muscle weakness. Symptoms can include a red skin rash around the eyelids, red bumps around the joints, and muscle weakness in the arms and legs. Muscle weakness gets worse over time and can lead to stiff joints and muscle wasting.
Dermatomyositis Symptoms
The signs and symptoms of dermatomyositis can appear suddenly or develop gradually over time. These features may be different from person to person. Some people may have more symptoms than others and symptoms can range from mild to severe. The most common signs and symptoms include:
- Skin changes- A violet-colored or dusky red rash develops, most commonly on the face and eyelids and on the knuckles, elbows, knees, chest and back. The rash, which can be itchy and painful, is often the first sign of dermatomyositis.
- Muscle weakness- Progressive muscle weakness involves the muscles closest to the trunk, such as those in the hips, thighs, shoulders, upper arms and neck. The weakness affects both the left and right sides of the body, and tends to gradually worsen.
Causes of Dermatomyositis
The cause of dermatomyositis is unknown, but the disease has much in common with autoimmune disorders, in which the immune system mistakenly attacks your body tissues. Genetic and environmental factors also might play a role. Environmental factors could include viral infections, sun exposure, certain medications and smoking.
Dermatomyositis Complications
Complications of dermatomyositis include:
- Difficulty swallowing- when the muscles in the esophagus are affected, dermatomyositis patients can have problems swallowing, which can cause weight loss and malnutrition.
- Aspiration pneumonia- Difficulty in swallowing can also cause dermatomyositis patients to breathe food or liquids, including saliva, into their own lungs.
- Breathing problems- If the condition affects the chest muscles, the dermatomyositis patients might have breathing problems, such as shortness of breath.
- Calcium deposits- These can occur in the muscles, skin and connective tissues as the dermatomyositis disease progresses. These deposits are more common in children with dermatomyositis and develop earlier in the course of the disease.
Dermatomyositis Associated Conditions
Dermatomyositis might cause other conditions which can put patients at higher risk of developing them, including:
- Raynaud’s Phenomenon- This condition causes the fingers, toes, cheeks, nose and ears to turn pale when exposed to cold temperatures.
- Other connective tissue diseases- Other conditions such as lupus, rheumatoid arthritis, scleroderma and Sjogren’s syndrome can occur with dermatomyositis.
- Cardiovascular disease. Dermatomyositis can cause heart muscle inflammation. In some dermatomyositis patients, congestive heart failure and heart rhythm problems develop.
- Lung disease. Interstitial lung disease can occur with dermatomyositis. Interstitial lung disease refers to a group of disorders that cause scarring of lung tissue, making the lungs stiff and inelastic. Signs include a dry cough and shortness of breath.
- Cancer– Chronic Dermatomyositis in adult patients has been linked to an increased likelihood of developing cancer, particularly ovarian cancer in women. Risk of cancer appears to level off three years or so after a diagnosis of dermatomyositis.
Detailed clinical data, elevated levels of antibodies, serology, biomarkers, Jo-1, MDA5, TIF1γ, Mi2, PL-7, PL-12, KS, EJ, genetic info, muscle biopsy tissue, pathology annotations, associated with the Dermatomyositis patient’s specimens is provided to a valued customer for drug discovery, development and research. The Dermatomyositis disease PBMC, sera (serum) and plasma are processed from patients peripheral blood using customized processing protocols provided by the researcher.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer sera (serum), cancer plasma, cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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