Bay Biosciences provides high quality, clinical grade samples, skin biopsy tissue samples, FFPE tissue blocks, sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with epidermolysis bullosa aquisita (EBA) Disease.

Moreover, the serum, plasma and PBMCs are processed from patient’s peripheral whole-blood using customized processing protocols.

In addition, detailed clinical annotations, associated with the EBA specimens is provided to a valued customer for drug discovery, development and research. 

Epidermolysis Bullosa Aquisita (EBA)

Epidermolysis Bullosa Aquisita (EBA) is a rare autoimmune disease characterized by sub-epithelial blistering of the skin and mucosal membranes in response to injury. Moreover, patients with EBA suffer from chronic inflammation as well as blistering and scarring of the skin and mucous membranes.

This mostly occurs in the hands, feet, knees, elbows, buttocks, mouth, nose, and eyes. Furthermore, EBA is not inherited and usually occurs in adulthood; specifically, it usually emerges mostly when patients are in their 40s or 50s. However, EBA can occur at any age.

In addition, some affected patients have other health problems such as Amyloidosis, Bullous Pemphigoid, Crohn’s disease, Systemic Lupus Erythematosus, and Multiple Myeloma. Consequently, treatment aims to protect the skin, stop the formation of blisters, and promote healing.

For this reason, immunosuppressive drugs may be used to reduce the body’s autoimmune response. Nevertheless, current treatment options rely on non-specific immunosuppression, which, in many cases, does not lead to a remission of treatment.

Symptoms & Types of Epidermolysis Acquisita (EBA)

Signs and Symptoms of Epidermolysis Bullosa Acquisita (EBA) can differ among affected patients; moreover, the condition has several distinct forms of onset. Additionally, the features of the condition in EBA patients may change during the course of the disease or may represent two forms at the same time.

For example:

Non-inflammatory or mildly inflammatory Epidermolysis Bullosa Acquisita (EBA)

In particular, non-inflammatory or mildly inflammatory Epidermolysis Bullosa Acquisita (EBA) affecting only trauma-prone skin (the “classic” form) may cause:

  • Tense, blood- or pus-filled blisters, mostly on the hands, knees, knuckles, elbows and ankles
  • Mucous-membrane blisters that rupture easily
  • Healing with significant scarring and small white spots (milia)

Generalized inflammatory Epidermolysis Bullosa Acquisita (EBA)

On the other hand, generalized inflammatory Epidermolysis Bullosa Acquisita (EBA) may cause:

  • Widespread blisters that are not localized to trauma-prone sites
  • Generalized redness and itching
  • Healing with minimal scarring

The Mucous Membrane form of Epidermolysis Bullosa Acquisita (EBA)

Furthermore, the mucous membrane form of EBA may cause:

  • Blisters on various mucous membranes
  • Significant scarring and dysfunction

What Causes Epidermolysis Bullosa Acquisita

The underlying causes of Epidermolysis Bullosa Acquisita (EBA) are unknown. However, researchers think it is an autoimmune disorder, which means that the immune system attacks healthy cells by mistake.

Specifically, in EBA, certain immune proteins, usually IgG autoantibodies, mistakenly target and attack a specific type of collagen (a skin protein) involved in “anchoring” the skin.

Furthermore, in some milder cases of EBA, experts think the immune proteins involved are IgA, rather than IgG autoantibodies. Ultimately, the initiating events that lead to autoantibody production are unknown.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.