Bay Biosciences provides high quality, clinical grade bio-samples, sera (serum), plasma and peripheral blood mononuclear cells (PBMC) bio-fluid specimens from patients diagnosed with Type-I Diabetes disease.

Moreover, the PBMC, sera and plasma samples are processed from patient’s peripheral whole-blood using customized processing protocols.

Diabetes

Diabetes mellitus, commonly known as diabetes, is a  metabolic disorder  that raises blood sugar levels. Specifically, the hormone insulin moves sugar from the blood into the cells to store it or use it for energy. However, with diabetes, the body either doesn’t produce enough insulin or can’t effectively use the insulin it produces. Consequently, untreated high blood sugar from diabetes can harm the nerves, eyes, kidneys, and other organs.

 

Types of Diabetes

There are a several different types of diabetes:

  • Furthermore, Type-1 Diabetes is an autoimmune disease. In this condition, the immune system attacks and destroys cells in the pancreas, where insulin is made. It’s unclear what causes this attack; nevertheless, usually, the body’s own immune system, which normally fights harmful bacteria and viruses, mistakenly destroys the insulin-producing (islet, or islets of Langerhans) cells in the pancreas. Additionally, other possible causes include genetics and exposure to viruses and other environmental factors.Moreover, Type-1 diabetes is an insulin-dependent diabetes, and it is a chronic condition in which the pancreas produces little or no insulin. Notably, insulin is a hormone needed to allow sugar to enter cells to produce energy. 
  • On the other hand, Type-2 Diabetes occurs when the body becomes resistant to insulin, and as a result, sugar builds up in the blood. 
  • In addition, Pre-Diabetes occurs when your blood sugar is higher than normal, but it’s not enough for a diagnosis.
  • Finally, Gestational Diabetes is high blood sugar during pregnancy. Insulin-blocking hormones produced by the placenta cause this type of diabetes.

Symptoms

Diabetes signs and symptoms can appear relatively suddenly and may include:

  • Increased thirst
  • Frequent urination
  • Bed-wetting in children who previously didn’t wet the bed during the night
  • Extreme hunger
  • Unintended weight loss
  • Irritability and other mood changes
  • Fatigue and weakness
  • Blurred vision

The role of Insulin

Once a significant number of islet cells are destroyed, the body produce little or no insulin. Specifically, insulin is a hormone that comes from a gland situated behind and below the stomach (pancreas).

  • First, the pancreas secretes insulin into the bloodstream.
  • Then, insulin circulates, allowing sugar to enter your cells.
  • Consequently, insulin lowers the amount of sugar in your bloodstream.
  • As a result, as your blood sugar level drops, so does the secretion of insulin from your pancreas.

The role of glucose

Glucose, a sugar is a main source of energy for the cells that make up muscles and other tissues.

  • In particular, glucose comes from two major sources, food and the liver.
  • Moreover, sugar is absorbed into the bloodstream, where it enters cells with the help of insulin.
  • Additionally, The liver stores glucose as glycogen.
  • Finally, when the glucose levels are low, such as when you haven’t eaten in a while, the liver breaks down the stored glycogen into glucose to keep your glucose levels within a normal range.

Finally, in Type-1 Diabetes, there’s no insulin to let glucose into the cells, so sugar builds up in the bloodstream. Consequently, this can cause life-threatening complications.

Treatment of Diabetes

Treatment aims to keep blood glucose levels stable at a healthy level and prevent complications. The main ways to do this are through lifestyle measures.

Specifically, these include:

  • Avoiding or quitting smoking
  • Doing physical activity
  • Eating plenty of fresh fruits and vegetables
  • Following a diabetes meal plan agreed with the healthcare team
  • Eating plenty of fresh fruits and vegetables
  • Reaching and maintaining a suitable BMI
  • Getting enough sleep
  • Taking medications or insulin as the doctor recommends
  • Keeping routine doctors appointments and regular blood tests

Additionally, some herbs and supplements may also help.

Outlook

Currently, researchers have not discovered a cure for diabetes; however, lifestyle measures can help most people manage their blood sugar levels and reduce  the risk of complications. If these do not help, then a doctor may prescribe medication.

Moreover, individuals who receive a diagnosis of prediabetes may be able to slow, stop, or even reverse the progress of diabetes.

On the other hand, if a person cannot manage their blood glucose levels, they may face complications. In fact, some of these can be life-threatening.

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

Customized Collections

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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