Bay Biosciences provides high-quality, fresh frozen samples, matched fresh frozen sera (serum), plasma, and peripheral blood mononuclear cells (PBMC) bio-fluids from patients diagnosed with diffuse idiopathic skeletal hyperostosis (DISH).
The sera (serum), plasma and PBMC biofluid specimens are processed from diffuse idiopathic skeletal hyperostosis (DISH) patient’s peripheral whole-blood using customized collection and processing protocols.
Fresh frozen tissue and matched biofluid samples are collected from unique patients diagnosed with diffuse idiopathic skeletal hyperostosis (DISH).
Bio-samples are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.
Diffuse Idiopathic Skeletal Hyperostosis (DISH) Overview
Diffuse idiopathic skeletal hyperostosis (DISH) also known as Forestier’s disease is a type of arthritis, where the ligaments and tendons become hardened. Usually DISH affects the spine, it can also occur in other areas throughout the body.
These calcified areas can also form bone spurs (abnormal new bone growth) that can cause pain, stiffness, and decreased mobility. DISH can be managed through physical therapy, surgery, medications and the application of heat.
DISH is uncommon in patients under 40 years old. It develops more often in patients over the age of 50, usually in the 60s and 70s. It affects more men than women.
The condition is generally managed clinically with analgesics and non-steroidal anti-inflammatory drugs when pain and stiffness are related.
Problems more serious than neck and back pain can develop. Bone spurs in the neck can put pressure on your esophagus, making it hard to swallow.
They can also cause a hoarse voice or sleep apnea, a problem in which the patient snore and repeatedly stop breathing during sleep. DISH can also increase the risk of spinal fractures.
DISH can occur with other types of arthritis, such as osteoarthritis, and can also sometimes be confused with ankylosing spondylitis because they both affect the spine and entheses.
Signs and Symptoms of Diffuse Idiopathic Skeletal Hyperostosis (DISH)
Most patients with diffuse idiopathic skeletal hyperostosis (DISH) have no or little symptoms. Doctors usually find DISH as an incidental finding when examining imaging (X-rays) for other reasons or for a different disease.
Following are some of the signs and symptoms of diffuse idiopathic skeletal hyperostosis (DISH):
- Numbness or tingling in legs
- Pain specially in the upper back ad neck
- Limited range of motion in the back
- Paralysis from a compressed spinal cord
- Reduced mobility
- Stiffness (usually worse in the morning)
- Trouble swallowing or hoarseness (nerves in the neck are compressed, if DISH develops in the neck)
- Tingling or numbness in your legs from compressed nerves in your lower back
Causes of Diffuse Idiopathic Skeletal Hyperostosis (DISH)
Exact causes of diffuse idiopathic skeletal hyperostosis (DISH) are unknown. As with most diseases, it’s probably a combination of genetic, environmental, metabolic and possibly mechanical factors. You’re more likely to get DISH if you:
- Are over age 5o years
- Are male
- Have diabetes or another condition that raises your insulin levels, such as pre-diabetes or obesity
- Have taken the acne medication, isotretinoin (Amnesteem, Claravis and others). Isotretinoin is a synthetic derivative of vitamin A. It’s not clear if natural vitamin A from food or supplements might also be a factor.
- Have unusual spine anatomy
- Repeatedly move or lift heavy objects
None of these factors alone causes DISH. For example, simply taking isotretinoin won’t lead to bone spurs. But if you’re also a man who has diabetes and does heavy physical work, the odds of getting DISH are higher.
Diagnosis of Diffuse Idiopathic Skeletal Hyperostosis (DISH)
A doctor diagnoses diffuse idiopathic skeletal hyperostosis (DISH) based on a thorough physical exam with imaging tests, including X-rays, MRIs and CT scans. These tests enable your doctor to see the bony growths.
Diagnostic tests help doctors rule out other problems that involve similar symptoms, including other types of arthritis.
Treatment of Diffuse Idiopathic Skeletal Hyperostosis (DISH)
Treatment cannot stop the calcification or bone growth associated with diffuse idiopathic skeletal hyperostosis (DISH). Instead, treatment aims to manage symptoms and keep the condition from progressing (getting worse).
Following are some of the treatment options for diffuse idiopathic skeletal hyperostosis (DISH):
- Applying Heat: This can help relieve early-morning pain and stiffness.
- Exercise and Physical Therapy: These are essential for getting back pain under control and improving stiffness and range of motion. Swimming is especially beneficial because it provides a full body workout without the risk of injury.
- Controlling Blood Sugar: Because DISH is often associated with obesity and diabetes, keeping your weight and blood sugar in a healthy range is important.
- Orthotics (special shoe inserts): These may make walking easier if you have bone spurs on your heels.
- Pain Relievers: Acetaminophen and nonsteroidal anti-inflammatories (NSAIDs) like ibuprofen can be used when needed. If exercise and physical therapy don’t relieve severe pain, corticosteroid injections may be an option. The goal of injections is to help you get back to exercise.
- Surgery: This would only be considered in rare cases when bone spurs compress your spinal cord or affect your ability to swallow.
Self Care
Along with following doctor’s instructions, getting the proper amount of physical activity, and strengthening the muscles that support the spine, you can manage your condition in additional ways.
Practicing healthy lifestyle habits will also help to improve your overall health and help you to manage your pain.
Eat a nutritious and balance diet that avoids sugary, fatty and processed foods. If you currently smoke, ask your doctor to help you quit.
Manage your emotional and mental health so you can cope with the challenges of your condition. Self-management encompasses the choices made each day to live well and stay healthy.
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Samples available are cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
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Including fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
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