Bay Biosciences provides high-quality, fresh frozen samples, matched fresh frozen sera (serum), plasma, and peripheral blood mononuclear cells (PBMC) bio-fluids from patients diagnosed with diffuse idiopathic skeletal hyperostosis (DISH).

The sera (serum), plasma and PBMC biofluid specimens are processed from diffuse idiopathic skeletal hyperostosis (DISH) patient’s peripheral whole-blood using customized collection and processing protocols.

Fresh frozen tissue and matched biofluid samples are collected from unique patients diagnosed with diffuse idiopathic skeletal hyperostosis (DISH).

Bio-samples are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.

Diffuse Idiopathic Skeletal Hyperostosis (DISH) Overview

Diffuse idiopathic skeletal hyperostosis (DISH) also known as Forestier’s disease is a type of arthritis, where the ligaments and tendons become hardened. Usually DISH affects the spine, it can also occur in other areas throughout the body.

These calcified areas can also form bone spurs (abnormal new bone growth) that can cause pain, stiffness, and decreased mobility. DISH can be managed through physical therapy, surgery, medications and the application of heat.

DISH is uncommon in patients under 40 years old. It develops more often in patients over the age of 50, usually in the 60s and 70s. It affects more men than women.

The condition is generally managed clinically with analgesics and non-steroidal anti-inflammatory drugs when pain and stiffness are related.

Problems more serious than neck and back pain can develop. Bone spurs in the neck can put pressure on your esophagus, making it hard to swallow.

They can also cause a hoarse voice or sleep apnea, a problem in which the patient snore and repeatedly stop breathing during sleep. DISH can also increase the risk of spinal fractures.

DISH can occur with other types of arthritis, such as osteoarthritis, and can also sometimes be confused with ankylosing spondylitis  because they both affect the spine and entheses.

Signs and Symptoms of Diffuse Idiopathic Skeletal Hyperostosis (DISH)

Most patients with diffuse idiopathic skeletal hyperostosis (DISH) have no or little symptoms. Doctors usually find DISH as an incidental finding when examining imaging (X-rays) for other reasons or for a different disease.

Following are some of the signs and symptoms of diffuse idiopathic skeletal hyperostosis (DISH):

  • Numbness or tingling in legs
  • Pain specially in the upper back ad neck
  • Limited range of motion in the back
  • Paralysis from a compressed spinal cord
  • Reduced mobility
  • Stiffness (usually worse in the morning)
  • Trouble swallowing or hoarseness (nerves in the neck are compressed, if DISH develops in the neck)
  • Tingling or numbness in your legs from compressed nerves in your lower back

Causes of Diffuse Idiopathic Skeletal Hyperostosis (DISH)

Exact causes of diffuse idiopathic skeletal hyperostosis (DISH) are unknown. As with most diseases, it’s probably a combination of genetic, environmental, metabolic and possibly mechanical factors. You’re more likely to get DISH if you: 

  • Are over age 5o years
  • Are male  
  • Have diabetes or another condition that raises your insulin levels, such as pre-diabetes or obesity
  • Have taken the acne medication, isotretinoin (Amnesteem, Claravis and others). Isotretinoin is a synthetic derivative of vitamin A. It’s not clear if natural vitamin A from food or supplements might also be a factor. 
  • Have unusual spine anatomy
  • Repeatedly move or lift heavy objects 

None of these factors alone causes DISH. For example, simply taking isotretinoin won’t lead to bone spurs. But if you’re also a man who has diabetes and does heavy physical work, the odds of getting DISH are higher. 

Diagnosis of Diffuse Idiopathic Skeletal Hyperostosis (DISH)

A doctor diagnoses diffuse idiopathic skeletal hyperostosis (DISH) based on a thorough physical exam with imaging tests, including X-rays, MRIs and CT scans. These tests enable your doctor to see the bony growths.

Diagnostic tests help doctors rule out other problems that involve similar symptoms, including other types of arthritis.

Treatment of Diffuse Idiopathic Skeletal Hyperostosis (DISH)

Treatment cannot stop the calcification or bone growth associated with diffuse idiopathic skeletal hyperostosis (DISH). Instead, treatment aims to manage symptoms and keep the condition from progressing (getting worse).

Following are some of the treatment options for diffuse idiopathic skeletal hyperostosis (DISH):

  • Applying Heat: This can help relieve early-morning pain and stiffness.
  • Exercise and Physical Therapy: These are essential for getting back pain under control and improving stiffness and range of motion. Swimming is especially beneficial because it provides a full body workout without the risk of injury.
  • Controlling Blood Sugar: Because DISH is often associated with obesity and diabetes, keeping your weight and  blood sugar in a healthy range is important.
  • Orthotics (special shoe inserts): These may make walking easier if you have bone spurs on your heels.
  • Pain Relievers: Acetaminophen and nonsteroidal anti-inflammatories (NSAIDs) like ibuprofen can be used when needed. If exercise and physical therapy don’t relieve severe pain, corticosteroid injections may be an option. The goal of injections is to help you get back to exercise.
  • Surgery: This would only be considered in rare cases when bone spurs compress your spinal cord or affect your ability to swallow. 

Self Care

Along with following doctor’s instructions, getting the proper amount of physical activity, and strengthening the muscles that support the spine, you can manage your condition in additional ways.

Practicing healthy lifestyle habits will also help to improve your overall health and help you to manage your pain.

Eat a nutritious and balance diet that avoids sugary, fatty and  processed foods. If you currently smoke, ask your doctor to help you quit.

Manage your emotional and mental health so you can cope with the challenges of your condition. Self-management encompasses the choices made each day to live well and stay healthy. 

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC Samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human bio-fluids from diseased and normal healthy donors which includes:

  • Firstly, peripheral whole-blood
  • Secondly, amniotic fluid
  • Thirdly, bronchoalveolar lavage fluid (BAL)
  • Next, sputum
  • Also, pleural effusion
  • Moreover, cerebrospinal fluid (CSF)
  • Likewise, serum (sera)
  • In addition, plasma
  • Moreover, peripheral blood mononuclear cells (PBMC) 
  • Furthermore, saliva
  • Next, buffy coat
  • Accordingly, urine
  • For example, Stool samples
  • Also, aqueous humor
  • And, vitreous humor
  • Lastly, kidney stones (renal calculi)
  • Finally, other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols. you buy donor-specific collections in higher volumes and specified sample aliquots from us in multiple format and sets.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.