Bay Biosciences provides high quality, clinical grade, biopsy tissue samples, FFPE tissue blocks with matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with endocrine disorders.
The sera (serum), plasma and PBMC biofluid specimens are processed from endocrine disorders patient’s peripheral whole-blood using customized collection and processing protocols. The endocrine disorders tissue and matched biofluid samples are collected from unique patients diagnosed with endocrine disorders and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.
Detailed clinical data, patient’s history, symptoms, complete blood count (CBC), serology, MRI, biopsy tissue findings, histopathology information, elevated biomarker levels, genetic and metabolic information associated with endocrine disorders specimens is provided to a valued customer for research, development and drug discovery.
The endocrine disorders sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluids are processed from patients peripheral whole-blood using customized collection and processing protocols.
Endocrine Disorders Overview
Human endocrine system is a network of glands located in the different parts of the body that produce and release hormones that control many important body functions, including the body’s ability to change calories into energy that powers cells and organs. The endocrine system influences how how your bones and tissues grow, how the heart beats, and even the ability to reproduce. The endocrine system plays a vital role in whether someone will develop thyroid disease, growth disorders, sexual dysfunction, diabetes and a host of other hormone-related disorders.
Endocrine System Glands
There are several different glands of the endocrine system, each gland releases specific hormones into the bloodstream. These hormones travel through the blood stream in the human body to other cells in the body and control and coordinate many body processes and functions. A small problem with the function of one or more of the endocrine system glands can throw off the delicate balance of hormones in the body and lead to an endocrine disease, or endocrine disorder.
Following are the glands of the endocrine system:
- Ovaries: Ovaries are the female reproductive organs that release eggs and produce sex hormones.
- Testes: The male reproductive glands that produce the sperm and sex hormones.
- Pancreas: Islet cells in the pancreas control the release of the glucagon and insulin hormones.
- Adrenal glands: Two glands that sit on top of the kidneys that release the hormone known as cortisol.
- Hypothalamus: A part of the lower middle brain that tells the pituitary gland when to release hormones.
- Thymus: Thymus gland is located in the upper chest that helps develop the body’s immune system early in life.
- Thyroid Gland: Thyroid gland is a butterfly-shaped gland in the front of the neck that controls metabolism.
- Parathyroid: Four tiny glands in the neck that play a role in bone development.
- Pineal gland: Pineal gland is located near the center of the brain that is linked to sleep patterns.
- Pituitary gland: A gland found at the base of the brain back of the sinuses. Pituitary gland is also known as the master gland because it influences many other glands, such as the thyroid gland. Problems with the pituitary gland can affect bone growth, a woman’s menstrual cycles, and the release of breast milk.
Types of Endocrine Disorders
There are many different types of endocrine disorders, including diabetes which is the most common endocrine disorder diagnosed in the United States.
Following are some of the endocrine disorders listed below:
Adrenal insufficiency: The adrenal gland releases not enough of the hormone cortisol and sometimes, aldosterone. Symptoms include upset stomach diarrhea, dehydration, fatigue, and skin conditions. Addison’s disease is a type of adrenal insufficiency.
Cushing syndrome: Overproduction of a pituitary gland hormone leads to an overactive adrenal gland. A similar condition called Cushing syndrome may occur in patients, who take high doses of corticosteroid drugs. Cushing syndrome is more common in children.
Gigantism (acromegaly) and other growth hormone problems: If the pituitary gland produces too much growth hormone, a child’s bones and body parts may grow abnormally fast. If growth hormone levels are too low, a child can stop growing in height.
Hyperthyroidism: The thyroid gland produces too much thyroid hormone, leading to weight loss, fast heart rate, sweating, and nervousness. The most common cause for an overactive thyroid is an autoimmune disorder called Graves’ disease. The thyroid gland does not produce enough thyroid hormone, leading to fatigue, constipation, dry skin, and depression. The underactive gland can cause slowed development in children, some types of hypothyroidism are present at birth in children.
Precocious puberty: Abnormally early puberty that occurs when glands tell the body to release sex hormones too soon in life.
Polycystic ovary syndrome (PCOS): Overproduction of androgens interfere with the development of eggs and their release from the female ovaries. PCOS is a leading cause of infertility in women patients.
Causes of Endocrine Disorders
Endocrine disorders are usually classified into the following two categories:
- Endocrine disease that are caused when an endocrine gland produces too much or too little of an endocrine hormone, this condition is known as hormone imbalance.
- Endocrine diseases which occur because of the development of lesions in the endocrine system, such as nodules or tumors, which may or may not affect hormone levels.
The endocrine’s feedback system helps control the balance of hormones in the bloodstream. If your body has too much or too little of a certain hormone, the feedback system signals the proper gland or glands to correct the problem. A hormone imbalance may occur if this feedback system has trouble keeping the right level of hormones in the bloodstream, or if your body doesn’t clear them out of the bloodstream properly.
Increased or decreased levels of endocrine hormone may be caused by the following reasosn:
- A problem with the endocrine feedback system
- Disease
- Failure of a gland to stimulate another gland to release hormones, for example, a problem with the hypothalamus can disrupt hormone production in the pituitary gland.
- A genetic disorder, such as multiple endocrine neoplasia (MEN) or congenital hypothyroidism.
- Infection
- Injury to an endocrine gland
- Tumor of an endocrine gland
Most endocrine Tumors and nodules (lumps) are noncancerous. They usually do not spread to other parts of the body. However, a tumor or nodule on the gland may interfere with the gland’s hormone production.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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