Bay Biosciences provides high quality, clinical grade, biopsy tissue samples, FFPE tissue blocks with matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with endocrine disorders.

Moreover, the serum, plasma and PBMCs are processed from endocrine disorders patient’s peripheral whole-blood using customized collection and processing protocols.

Furthermore, the tissue and matched bio-fluid samples are collected from unique patients diagnosed with endocrine disorders and are provided to a valued pharmaceutical customer for research.

In addition, detailed clinical data, patient’s information associated with endocrine disorders specimens is provided to a valued customer for research, development and drug discovery.

Endocrine Disorders Overview

Human endocrine system is a network of glands located in different parts of the body that produce and release hormones that control many important body functions. For instance, these functions include the body’s ability to change calories into energy that powers cells and organs.

Additionally, the endocrine system influences how your bones and tissues grow, how the heart beats, and even the ability to reproduce. Consequently, the endocrine system plays a vital role in whether someone will develop thyroid disease, growth disorders, sexual dysfunction, diabetes, and a host of other hormone-related disorders.

Endocrine System Glands

Moreover, there are several different glands of the endocrine system, and each gland releases specific hormones into the bloodstream. These hormones, in turn, travel through the bloodstream in the human body to other cells and control and coordinate many body processes and functions.

Thus, a small problem with the function of one or more of the endocrine system glands can throw off the delicate balance of hormones in the body, ultimately leading to an endocrine disease or endocrine disorder.

Following are the glands of the endocrine system:

  • Ovaries: Ovaries are, in fact, the female reproductive organs that release eggs and produce sex hormones.
  • Additionally, Testes: The male reproductive glands, on the other hand, produce the sperm and sex hormones. \
  • Moreover, Pancreas: Islet cells in the pancreas, specifically, control the release of the glucagon and insulin hormones.
  • Furthermore, Adrenal glands: Two glands that sit on top of the kidneys, consequently, release the hormone known as cortisol.
  • In addition, Hypothalamus: A part of the lower middle brain, which is crucial, tells the pituitary gland when to release hormones.

Additional Glands

  • Similarly, Thymus: The thymus gland, located in the upper chest, plays a vital role in helping develop the body’s immune system early in life.
  • As a result, Thyroid Gland: The thyroid gland, which is a butterfly-shaped gland in the front of the neck, controls metabolism.
  • Notably, Parathyroid: Four tiny glands in the neck, therefore, play a role in bone development.
  • Additionally, Pineal gland: The pineal gland is located near the center of the brain and is linked to sleep patterns.
  • Lastly,Pituitary gland: A gland found at the base of the brain, at the back of the sinuses, the pituitary gland is also known as the master gland because it influences many other glands, such as the thyroid gland. Consequently, problems with the pituitary gland can affect bone growth and a woman’s menstrual cycle.

Types of Endocrine Disorders

There are many different types of endocrine disorders, including diabetes which is the most common endocrine disorder diagnosed in the United States.

Following are some of the endocrine disorders listed below:

Adrenal insufficiency

First, Adrenal insufficiency: The adrenal gland releases not enough of the hormone cortisol and sometimes, aldosterone. Symptoms include upset stomach diarrhea, dehydration, fatigue, and skin conditions. Addison’s disease is a type of adrenal insufficiency.

Cushing’s Syndrome

Second, Cushing Syndrome: Overproduction of a pituitary gland hormone leads to an overactive adrenal gland. A similar condition called Cushing syndrome may occur in patients, who take high doses of corticosteroid drugs. Cushing syndrome is more common in children.

Gigantism

Third, Gigantism (acromegaly) and other growth hormone problems: If the pituitary gland produces too much growth hormone, a child’s bones and body parts may grow abnormally fast. If growth hormone levels are too low, a child can stop growing in height.

Hyperthyroidism

Moreover, Hyperthyroidism: The thyroid gland produces too much thyroid hormone, leading to weight loss, fast heart rate, sweating, and nervousness. The most common cause for an overactive thyroid is an autoimmune disorder called Graves’ disease. The thyroid gland does not produce enough thyroid hormone, leading to fatigue, constipation, dry skin, and depression. The underactive gland can cause slowed development in children, some types of hypothyroidism are present at birth in children.

Precocious puberty

Furthermore, Precocious puberty: Abnormally early puberty that occurs when glands tell the body to release sex hormones too soon in life.

Hypopituitarism

In addition, Hypopituitarism: Hypopituitarism is a condition where the pituitary gland releases little or no hormones. It may be caused by a number of different diseases. Women with hypopituitarism may stop getting their periods regularly.

Multiple Endocrine Neoplasia

Likewise, Multiple Endocrine Neoplasia I and II (MEN I and MEN II): These rare genetic conditions are passed down through families. They cause tumors of the parathyroid, adrenal, and thyroid glands, leading to overproduction of hormones.

Polycystic ovary syndrome (PCOS)

Lastly, Polycystic ovary syndrome (PCOS): Overproduction of androgens interfere with the development of eggs and their release from the female ovaries. PCOS is a leading cause of infertility in women patients.

Causes of Endocrine Disorders

Endocrine disorders are usually classified into the following two categories:

  • Endocrine disease that are caused when an endocrine gland produces too much or too little of an endocrine hormone, this condition is known as hormone imbalance.
  • Endocrine diseases which occur because of the development of lesions in the endocrine system, such as nodules or tumors, which may or may not affect hormone levels.

The endocrine’s feedback system helps control the balance of hormones in the bloodstream. If your body has too much or too little of a certain hormone, the feedback system signals the proper gland or glands to correct the problem. A hormone imbalance may occur if this feedback system has trouble keeping the right level of hormones in the bloodstream, or if your body doesn’t clear them out of the bloodstream properly.

Increased or decreased levels of endocrine hormone may be caused by the following reasosn:

  • A problem with the endocrine feedback system
  • Disease
  • Failure of a gland to stimulate another gland to release hormones, for example, a problem with the hypothalamus can disrupt hormone production in the pituitary gland.
  • A genetic disorder, such as multiple endocrine neoplasia (MEN) or congenital hypothyroidism.
  • Infection
  • Injury to an endocrine gland
  • Tumor of an endocrine gland

Most endocrine Tumors and nodules (lumps) are noncancerous. They usually do not spread to other parts of the body. However, a tumor or nodule on the gland may interfere with the gland’s hormone production.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.