Bay Biosciences provides fresh frozen tissue samples from Ovarian cancer patients with associated clinical data to a pharmaceutical customer for research, developments and discovery.

Ovarian Cancer Overview

Ovarian cancer, therefore, affects the ovaries and ranks as one of the most common types of cancer in women. Additionally, it accounts for more deaths than any other cancer of the female reproductive system.

The ovaries, which are, in fact, a pair of small organs located low in the tummy, connect to the womb and store a woman’s supply of eggs.

Furthermore, ovarian cancer mainly impacts women who have been through the menopause (usually over the age of 50); however, it can sometimes affect younger women as well. Consequently, ovarian cancer stands as the second most common gynecologic cancer  in the United States.

According to the American Cancer Society (ACS) round 21,410 patients will receive a new diagnosis of ovarian cancer this year. There will be around 13,770 deaths due to ovarian cancer.

Types of Ovarian Cancer

The type of cell where the cancer begins determines your type of ovarian cancer and, consequently, helps your doctor choose the best treatments for you. Ovarian cancer types include:

  • First, epithelial ovarian cancer. This type is the most common; in fact, it includes several subtypes, including serous carcinoma and mucinous carcinoma.
  • Additionally, stromal tumors. These rare tumors are usually diagnosed at an earlier stage than other ovarian cancers.
  • Lastly, germ cell tumors. These rare ovarian cancers tend to occur at a younger age.

Signs and Symptoms of Ovarian Cancer

Following are the common signs and symptoms in ovarian cancer patients:

Causes of Ovarian Cancer

Doctors have identified things that can increase the risk of ovarian cancer; however, it’s not clear what causes it.

Doctors know that, specifically, changes (mutations) in the DNA of cells in or near the ovaries cause ovarian cancer to begin. In fact, a cell’s DNA provides the instructions that tell the cell what to do.

Consequently, the changes instruct the cells to grow and multiply quickly, thereby creating a mass (tumor) of cancer cells. Furthermore, the cancer cells continue to live when healthy cells would die.

As a result, they invade nearby tissues and break off from an initial tumor to spread (metastasize) to other parts of the body.

Risk Factors of Ovarian Cancer

Following are some of the several different factors can increase a patients risk of developing ovarian cancer:

  • Older age
  • Family history of ovarian cancer, breast cancer, or colorectal cancer
  • Being overweight and obese
  • Hormone treatment after menopause
  • Giving birth after 35 years of age
  • Not having full-term (9 months) pregnancy
  • In-vitro fertilization treatment
  • Exposure to talcum powder
  • Having irregular menstrual cycles

Following are some of the factors that may help prevent ovarian cancer:

Prevention of Ovarian Cancer

There’s no sure way to prevent ovarian cancer. However, there may be ways to reduce your risk:

  • First, consider taking birth control pills. In this regard, ask your doctor whether birth control pills (oral contraceptives) may be right for you. Notably, taking birth control pills reduces the risk of ovarian cancer. Nevertheless, these medications do have risks, so it is important to discuss whether the benefits outweigh those risks based on your situation.
  • Additionally, discuss your risk factors with your doctor. If you have a family history of breast and ovarian cancers, **then** discuss this with your doctor. **In addition,** your doctor can determine what this may mean for your own risk of cancer. **Furthermore,** they may refer you to a genetic counselor who can help you decide whether genetic testing may be right for you. **Consequently,** if you have a gene change that increases your risk of ovarian cancer, you may consider surgery to remove your ovaries to prevent cancer.

Diagnosis of Ovarian Cancer

Tests and procedures that doctors use to diagnose ovarian cancer include:

  • First, Pelvic Exam: During a pelvic exam, your doctor inserts gloved fingers into your vagina and simultaneously presses a hand on your abdomen to feel (palpate) your pelvic organs. **In addition**, the doctor also visually examines your external genitalia, vagina, and cervix.
  • Moreover, Imaging Tests: Imaging tests, such as ultrasound or CT scans of your abdomen and pelvis, may help doctors determine the size, shape, and structure of your ovaries
  • Furthermore, Blood Tests: Blood tests might include organ function tests that can help you determine your overall health. Additionally, your doctor might also test you for tumor markers that indicate ovarian cancer. For example, a cancer antigen (CA) 125 test can detect a protein that often appears on the surface of ovarian cancer cells. However, these tests can’t tell you whether you have cancer; instead, they may provide clues about your diagnosis and prognosis.
  • In Addition, Surgery: In some cases, your doctor can’t be certain of your diagnosis until you undergo surgery to remove an ovary and test it for signs of cancer
  • Finally, Genetic testing: Your doctor may recommend that you test a sample of your blood to look for gene changes that increase the risk of ovarian cancer. Furthermore, knowing you have an inherited change in your DNA helps you inform your doctor about decisions regarding your treatment plan. Consequently, you may wish to share the information with your blood relatives, such as your siblings and your children, **because** they may also face a risk of having those same gene changes.

Treatment of Ovarian Cancer

Doctors usually treat ovarian cancer with a combination of surgery and chemotherapy. Additionally, they may use other treatments in certain situations.

Surgery

Surgeons perform operations to remove ovarian cancer, including:

For instance, they remove one ovary. In particular, for early-stage cancer that hasn’t spread beyond one ovary, they may remove the affected ovary and its fallopian tube. Consequently, this procedure may preserve your ability to have children.

Your surgeon may remove both ovaries and both fallopian tubes if cancer is present in both your ovaries; however, there are no signs of additional cancer. Consequently, this procedure keeps your uterus intact, thereby allowing you to still be able to become pregnant using your own frozen embryos or eggs or, alternatively, with eggs from a donor.

The surgeon will perform surgery to remove both ovaries and the uterus. However, if your cancer is more extensive or if you don’t wish to preserve your ability to have children, then the surgeon will remove the ovaries, the fallopian tubes, the uterus, nearby lymph nodes, and a fold of fatty abdominal tissue (omentum).

Surgery for advanced cancer. If you have advanced cancer, your doctor may recommend surgery to remove as much of the cancer as possible. Additionally, sometimes they give chemotherapy before or after surgery in this situation.

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

Customized Collections

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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