Bay Biosciences provides high quality, clinical grade bio-samples, biopsy tissue samples, FFPE tissue blocks, sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid specimens from patients diagnosed with Goodpasture’s syndrome (Anti-GBM disease).

The sera (serum), plasma and PBMC biofluid specimens are processed from Goodpasture’s syndrome (Anti-GBM disease) patient’s peripheral whole-blood using customized collection and processing protocols.

The Goodpasture’s syndrome (Anti-GBM disease) tissue and matched biofluid samples are collected from unique patients diagnosed with Goodpasture’s syndrome (Anti-GBM disease) and are provided to a valued pharmaceutical customer for research, discovery and drug development.

Detailed clinical data, Goodpasture’s syndrome (Anti-GBM disease) patient’s history, symptoms, complete blood count (CBC), serology, MRI, biopsy tissue, histopathology, elevated biomarker levels, serum creatinine levels, genetic and metabolic data associated with Goodpasture’s syndrome (Anti-GBM disease) specimens is provided to a valued customer for research, development and drug discovery.

Goodpasture’s Syndrome (Anti-GBM disease) Overview

Anti-GBM is a rare disease also known as Goodpasture’s syndrome is an autoimmune disorder in which the body’s immune system creates antibodies that attack the kidneys and the lungs. Anti-GBM disease (Goodpasture’s syndrome) characterized by rapidly progressive glomerulonephritis accompanied by pulmonary hemorrhage.

As a result, a patient may develop glomerulonephritis inflammation of the glomeruli (which are tiny units in the kidney’s that filter wastes and extra fluid from the blood) and bleeding in the lungs, either one or both of these conditions.

Anti-GBM disease most often affects men in their 20s and women in their 60s, but it can occur at any age. The condition can occur in children, but this is extremely rare.

Signs and Symptoms of Goodpasture’s Syndrome (Anti-GBM disease)

Goodpasture’s Syndrome (Anti-GBM disease) most often starts with the following signs and symptoms:

Following  signs and symptoms may appear before or along with symptoms of lung and kidney problems.

Signs and symptoms of lung problems may include:

Signs and symptoms of kidney problems may include:

Complications of Goodpasture’s Disease (Anti-GBM disease)

Complications can occur quickly due to Goodpasture’s syndrome without treatment. As the disease progresses, about 80–90% of people with the condition develop kidney glomerulonephritis. This involves inflammation in the part of the kidney responsible for filtering waste.

Kidney inflammation can lead to complications, including kidney failure, which may require short- or long-term dialysis. Typically, under 30% of survivors with Goodpasture’s syndrome require long-term dialysis.

About 50% of people with the condition also experience bleeding in the lungs. This may progress to respiratory failure, which can lead to requiring a breathing tube and mechanical ventilator to assist breathing.

Diagnosis of Goodpasture’s Disease (Anti-GBM disease)

Doctors diagnose Goodpasture’s syndrome according to a person’s symptoms, medical history, physical exam, and diagnostic tests.

A kidney biopsy, when doctors remove a tissue sample, is the gold standard for diagnosing the condition. The presence of anti-GBM antibodies on a biopsy specimen confirms the diagnosis.

Additional diagnostic tests also help rule out other conditions and indicate a need for a kidney biopsy. Tests may include:

  • First, a urinalysis to check for blood in the urine
  • Next, kidney function tests to determine damage
  • In addition, blood tests to reveal anemia due to blood loss
  • Lastly, a chest X-ray to identify bleeding in the lungs

The tests above are less invasive than a kidney biopsy and typically help provide clues to the diagnosis.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC Samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols. you buy donor-specific collections in higher volumes and specified sample aliquots from us in multiple format and sets.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.