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Heartburn

Heartburn is a burning feeling in the chest caused by stomach acid travelling up towards the throat (acid reflux). If it keeps happening, more than twice a week, it’s called gastroesophageal reflux disease (GERD). Heartburn is felt when stomach acid flows back up into the esophagus, the pipe that carries food from the mouth to the stomach. Heartburn is a symptom of GERD.

According to the American College of Gastroenterology it is estimated that more than 60 million Americans experience heartburn at least once a month and at least 15 million experience heartburn every day.

  • Heartburn causes include diet, obesity, and lack of exercise.
  • The primary symptom is a burning sensation in the throat or chest from stomach acid.
  • In many cases, heartburn has little bearing on overall health.
  • There are many treatments, including PPI medications (proton-pump inhibitors).

Causes of Heartburn

Occasional heartburn is normal and is rarely a significant cause for concern. Recurrent acid reflux results in the diagnosis of gastroesophageal reflux disease (GERD ) and can have serious consequences for health and indicate other underlying health issues. GERD is seen in people of all ages, and the cause is often attributable to a lifestyle factors, such as obesity, smoking, and low levels of exercise. 

Normally when you swallow food, a band of muscle around the bottom of the esophagus (lower esophageal sphincter) relaxes to allow food and liquid to flow down into the stomach. Then the muscle tightens again. If the lower esophageal sphincter relaxes abnormally or weakens, stomach acid can flow back up into your esophagus (acid reflux) and cause heartburn. The acid backup may be worse when you’re bent over or lying down.

Signs and Symptoms of Heartburn

Most common signs and symptoms of heartburn are feeling of warmth or heat, sometimes burning, in the chest and throat, caused by the stomach acid. Other symptoms of heartburn include:

  • Burning sensation in the middle of the chest 
  • Pain worsens when lying down or bending over
  • Rising pain, possibly reaching the jaw
  • Burning and indigestion-like pain
  • Foul, bitter or acidic taste in the mouth

Risk Factors of Heartburn

Being overweight or pregnant also can increase your risk of experiencing heartburn. Certain foods and drinks can trigger heartburn in some people, including:

  • Spicy or acidic foods
  • Onions
  • Citrus products
  • Tomato products, such as ketchup
  • Fatty or fried foods
  • Peppermint
  • Chocolate
  • Alcohol, carbonated beverages, coffee or other caffeinated beverages
  • Large or fatty meals

 

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.

All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness. 

Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samplestumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serumplasma and PBMC’s.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures. 

In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.

 

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