Interstitial Lung Disease (ILD) Samples

Bay Biosciences provides high-quality, fresh frozen bronchoalveolar lavage (BAL) fluid samples with matched serum (sera) and plasma samples from unique interstitial lung disease patients and age matched normal healthy donors for research.

The bronchoalveolar lavage (BAL) fluid samples samples and matched K2EDTA plasma, sera (serum) and PBMC bio-fluid specimens are processed from interstitial lung disease (ILD) patient’s whole BAL fluid and peripheral whole-blood using customized sample collection and processing protocols.

Interstitial lung disease (ILD) patient’s bronchoalveolar lavage (BAL) and matched bio-fluid samples  are used for research, development and drug discovery.

Overview of Interstitial Lung Disease (ILD)

Interstitial lung disease is a group of conditions that cause scarring in your lungs. However, the scarring often leads to breathing problems, which can range from mild to severe.

In fact, interstitial lung disease includes over 200 different conditions that cause inflammation and scarring around the balloon-like air sacs in your lungs, called the alveoli. Also, oxygen travels through the alveoli into your bloodstream. Therefore When they are scarred, these sacs do not expand well. As a result, less oxygen enters your blood.

Also, other parts of your lungs can be affected too, such as the airways, lung lining, and blood vessels.

Types of Interstitial Lung Disease

There are over 200 different types of interstitial lung disease. Some of these include:

  • Asbestosis: inflammation and scarring in the lungs caused by breathing in asbestos fibers
  • Bronchiolitis obliterans: a condition that causes blockages in the smallest airways of the lungs, called bronchioles
  • Coal worker’s pneumoconiosis: a lung condition caused by exposure to coal dust (also called black lung disease)
  • Chronic silicosis: a lung disease caused by breathing in the mineral silica
  • Connective tissue-related pulmonary fibrosis: a lung disease that affects some people with connective tissue diseases, such as scleroderma or Sjögren’s Syndrome
  • Desquamative interstitial pneumonitis: a condition that causes lung inflammation and is more common in people who smoke
  • Familial pulmonary fibrosis: a buildup of scar tissue in the lungs that affects two or more members of the same family
  • Hypersensitivity pneumonitis: inflammation of the alveoli caused by breathing in allergens or other irritants
  • Idiopathic pulmonary fibrosis: a disease of unknown cause in which scar tissue develops throughout the lung tissue
  • Sarcoidosis: a disease that causes small clumps of inflammatory cells to form in organs such as the lungs and lymph nodes

Symptoms of Interstitial Lung Disease (ILD)

When you have interstitial lung disease, lung damage, irritation, and lack of oxygen can cause a variety of symptoms. These include:

Symptoms can range in severity and may be similar to those associated with other respiratory conditions or health problems.

See your doctor if you notice shortness of breath or other unusual symptoms. If your symptoms are caused by interstitial lung disease, you can start treatments to manage the inflammation and scarring.

Causes of Interstitial Lung Disease (ILD)

Many times, doctors can’t find the cause of interstitial lung disease. In these cases, the condition is called idiopathic interstitial lung disease.

Other causes of interstitial lung disease include medical conditions, the use of some medications, or exposure to toxic substances that damage your lungs. These causes of interstitial lung disease are grouped into three main categories:

Autoimmune Diseases

Your body’s immune system attacks and damages the lungs and other organs in these conditions:

  • Dermatomyositis: an inflammatory disease that causes muscle weakness and skin rash
  • Lupus: A condition in which the immune system attacks many types of tissue, including the skin, joints, and other organs
  • Mixed connective tissue disease: A  disease that has symptoms of several connective tissue diseases, including polymyositis, lupus, and scleroderma
  • Polymyositis: A disease that causes inflammation of the muscles
  • Vasculitis: Inflammation and damage to blood vessels in the body
  • Rheumatoid arthritis: A condition in which the immune system attacks the joints, lungs, and other organs
  • Sarcoidosis: A condition involving clumps of inflammatory cells that form in various organs
  • Scleroderma: A group of diseases that cause the skin and connective tissue to thicken and tighten
  • Sjögren’s syndrome: A condition that causes joint pain, dry eyes, and dry mouth

Exposure to toxic substances or irritants

Exposure to the following substances at work or in the environment can cause lung scarring as well:

  • Animal proteins, such as from farming, or raising birds
  • Asbestos fibers
  • Coal dust
  • Grain dust
  • Mold
  • Silica dust
  • Tobacco smoke

Medications

Some medications can damage the lungs, such as:

Treatment for Interstitial Lung Disease (ILD)

Treatments can’t reverse lung scarring if it has already occurred, but they may help to prevent further scarring or slow down disease progression.

However, if exposure to a toxic material or drug caused your interstitial lung disease, it’s important to avoid that substance.

Your doctor can prescribe a few different types of treatments to manage interstitial lung disease:

  • Anti-inflammatory drugs, such as the steroid prednisolone, can reduce inflammation in the lungs.
  • Immune-suppressing drugs may help stop immune system attacks that can damage the lungs.
  • Supplemental oxygen can help you increase your oxygen levels, if they’re low.
  • Pulmonary rehabilitation may help improve your activity levels and ability to exercise.
  • Antifibrotic drugs such as pirfenidone (Esbriet) and nintedanib (Ovef) may prevent further scarring in the lungs. These drugs are both approved by the Food and Drug Administration (FDA) for the treatment of Idiopathic pulmonary fibrosis (IPF).

If your condition is severe and other treatments don’t help, your doctor may recommend a lung transplant. Typically, this surgery is not recommended if you’re over the age of 75 years or you have certain serious health conditions.

 

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Biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Samples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Also, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

So this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

Moreover, we can also procure most human bio-specimens, special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.