Bay Biosciences provides high-quality, matched fresh frozen sera (serum),  plasma, and peripheral blood mononuclear cells (PBMC) bio-fluids from patients diagnosed with Sjögren’s syndrome.

Moreover, the sera (serum), plasma and PBMC bio-fluids are processed from Sjögren’s syndrome patient’s peripheral whole-blood using customized collection and processing protocols.

In addition, the matched bio-fluids are collected from unique patients with Sjögren’s syndrome and are provided to a valued pharmaceutical customer for research, development and drug discovery.

 

Sjögren’s Syndrome Overview

In fact, Sjögren’s syndrome  (SS) is a systemic, long-term autoimmune disease that affects the body’s moisture-producing (lacrimal and salivary) glands and often seriously affects other organs systems, such as the lungs, kidneys, and nervous system. Moreover, doctors identify Sjögren’s syndrome by its two most common symptoms, dry eyes and a dry mouth.

The condition often accompanies other immune system disorders, such as rheumatoid arthritis and Systemic Lupus Erythematosus (SLE). About half of the time Sjögren’s syndrome occurs alone. And the other half it occurs in the presence of another autoimmune connective tissue disease.

In Sjogren’s syndrome, the condition usually affects the mucous membranes and moisture-secreting glands of the eyes and mouth first, resulting in decreased tears and saliva.

Although Sjogren’s syndrome can develop in patients at any age, most patients affected are older than 40 years at the time of diagnosis. The condition is much more common in older women. Treatment focuses on relieving symptoms. As a systemic disease, affecting the entire body, symptoms may remain steady or worsen overtime.

According to the Sjögren’s foundation, researchers estimate that four million Americans are living with this disease, making it one of the most prevalent autoimmune diseases in the United States.

According to the Sjögren’s foundation, researchers estimate that four million Americans are living with this disease, making it one of the most prevalent autoimmune diseases in the United States.

Causes of Sjögren’s Syndrome

Exact  causes of Sjögren’s syndrome are unknown, but it is an autoimmune disease. Patients with Sjögren’s syndrome have abnormal proteins in their blood.

This suggests that the immune system, which normally functions to protect the body against cancers and infections. Reacts against its own tissue. The decrease in tears and saliva seen in Sjögren’s syndrome occurs. When the glands that produce these fluids are damaged by inflammation. Research suggests that genetic factors and possibly viral infections may predispose people to developing Sjögren’s syndrome.

Signs and Symptoms of Sjögren’s Syndrome

Dry mouth is a common symptom of Sjögren’s syndrome, which can increase the risk of cavities. It can also make it more difficult to speak or swallow. Chewing gum or sucking on candies may help with this symptom. In Sjögren’s syndrome dryness of the eyes often occur, too. This may feel like a burning sensation or like something is in your eye.

Sjögren’s syndrome can affect the whole body. Some individuals have vaginal dryness, dry skin, fatigue, rashes, or joint pain. Sjögren’s syndrome can cause inflammation of organs like the kidneys or lungs. Sjögren’s syndrome patients may have constant inflammation, your doctor might prescribe medications to help prevent organ damage. These medications are called disease-modifying antirheumatic drugs. They help tamp down the immune system even more than immune-suppressing drugs.

Risk Factors of Sjögren’s Syndrome

There’s no one specific cause or risk factor for developing Sjögren’s syndrome. Nine out of 10 patients who have Sjögren’s syndrome are women, and postmenopausal women are particularly likely to develop the problem. Research is currently being done to see if estrogen is associated with the condition.

Other autoimmune disorders are often present, and a family history of the condition appears to increase your risk of developing Sjögren’s syndrome.

Diagnosis of Sjögren’s Syndrome

Sjögren’s syndrome diagnosis depends on a combination of symptoms, physical examination, blood tests, and sometimes special studies. Dry eyes and mouth may be early signs of the condition but require further investigation, because these symptoms can be caused by many other conditions or side effects of medications. Special tests may assess any decrease in tear or saliva production. An eye examination is helpful in detecting any eye changes seen in Sjögren’s syndrome. Blood tests can determine the presence of antibodies (immune system proteins that help destroy foreign invaders) typical of the disease. Typical antibodies include anti-nuclear antibodies (ANA), anti-SSA and SSB antibodies or rheumatoid factor, but these are not always present. Biopsies of saliva glands around the face or under the surface of the inner lip also may be used to make a diagnosis.

Treatment of Sjögren’s Syndrome

Sjögren’s syndrome treatment is designed to lessen the most bothersome symptoms. Dry eyes usually respond to artificial tears applied regularly during the day or to gels applied at night. Other measures, such as plugging or blocking tear ducts, can be used in more severe cases. Eye drops that reduce inflammation in the glands around the eyes, such as cyclosporine (Restasis), may be used to increase tear production.

Drinking water, chewing gum, or using saliva substitutes may relieve dry mouth. Some Sjögren’s syndrome patients benefit from using prescription medications that stimulate saliva flow, such as pilocarpine (Salagen) or cevimuline (Evoxac). If patients develop yeast infections, anti-fungal therapies may be used. Humidifiers and nasal saline irrigation may improve nasal dryness. Medications that reduce gastric acid (such as proton-pump inhibitors and H2 blockers) may lessen symptoms of acid reflux. Treatments may help relieve some of the dryness, but usually some dryness persists.

Sjögren’s syndrome patients should receive regular dental care to prevent cavities and tooth loss that may occur as a complication of Sjögren’s. Patients with dry eyes should see an ophthalmologist (eye doctor) regularly for signs of damage to the cornea. Patients with excessive redness and pain in the eyes should be evaluated for infections.

Hydroxychloroquine (Plaquenil), an antimalarial drug used in lupus and rheumatoid arthritis, may be helpful in some patients with Sjögren’s syndrome by reducing joint pain and rash experienced. Patients with rare but serious systemic symptoms, such as fever, rashes, abdominal pain, or lung and kidney problems, may require treatment with corticosteroids such as prednisone (Deltasone) and/or immunosuppressive agents like methotrexate (Rheumatrex), azathioprine (Imuran), mycophenolate (Cellcept) or cyclophosphamide (Cytoxan). In addition, researchers are evaluating rituximab (Rituxan) and other biological therapies to treat cases of Sjögren’s that affect the entire body.

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC) and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, researchers find patient’s data extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

  • Firstly, Peripheral whole-blood
  • Secondly, Amniotic fluid
  • Third, Bronchoalveolar lavage fluid (BAL)
  • Moreover, Sputum
  • Furthermore, Pleural effusion
  • Next, Cerebrospinal fluid (CSF)
  • Also, Serum (sera)
  • Likewise, Plasma
  • In addition, Peripheral blood mononuclear cells (PBMC)
  • For example, Saliva
  • Also, Buffy coat
  • Moreover, Urine
  • Furthermore, stool samples
  • Next, Aqueous humor
  • Likewise, Vitreous humor
  • Lastly, Kidney stones (renal calculi)
  • Finally, Other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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