Bay Biosciences provides high quality, clinical grade, biopsy tissue samples, FFPE tissue blocks with matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with kidney cancer.
The sera (serum), plasma and PBMC biofluid specimens are processed from kidney cancer patient’s peripheral whole-blood using customized collection and processing protocols.
Kidney cancer tissue and matched biofluid samples are collected from unique patients diagnosed with Kidney cancer and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.
Detailed clinical data, patient’s history, symptoms, complete blood count (CBC), serology, MRI, biopsy tissue findings, histopathology information, elevated biomarker levels, genetic and metabolic information associated with kidney cancer specimens is provided to a valued customer for research, development and drug discovery.
The kidney cancer sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluids are processed from patients peripheral whole-blood using customized collection and processing protocols.
Kidney Cancer Overview
Kidney cancer also known as renal cell carcinoma (RCC), is a disease in which kidney cells become malignant (cancerous) and grow out of control, forming a tumor. About 7 out of 10 kidney cancer patients have renal cell carcinoma (RCC).
Renal cell carcinoma or kidney cancer begins in the kidneys. The kidneys are two bean-shaped organs, each about the size of a fist. They’re located behind the abdominal organs, with one kidney on each side of the spine. Almost all kidney cancers first appear in the lining of tiny tubes (tubules) in the kidney.
In adults, renal cell carcinoma is the most common type of kidney cancer. Other less common types of kidney cancer can occur in young children called Wilms tumor.
Types of Kidney Cancer
Renal Cell Carcinoma
Renal cell carcinoma (RCC), also known as renal cell cancer or renal cell adenocarcinoma, is the most common type of kidney cancer. RCC usually grows as a single tumor within a kidney, sometimes there are 2 or more tumors in one kidney or even tumors in both kidneys at the same time.
Clear-Cell Renal Cell Carcinoma
This is the most common form of renal cell carcinoma. When seen in the lab, the cells that make up clear cell RCC look very pale or clear.
Non-clear cell Renal Cell Carcinoma
Papillary Renal Cell Carcinoma
Papillary renal cell carcinoma: This is the second most common subtype, about 1 in 10 RCCs are of this type. These cancers form little finger-like projections (called papillae) in some of the tumors.
Chromophobe Renal Cell Carcinoma
Chromophobe Renal cell carcinoma: This subtype accounts for about 5% of RCCs. The cells of these cancers are also pale, like the clear cells, but are much larger and have certain other features that can be recognized when looked at very closely.
Rare types of renal cell carcinoma: Some of the following are rare type of RCC’s, each making up less than 1% of RCCs:
- Collecting duct RCC
- Multilocular cystic RCC
- Medullary carcinoma
- Mucinous tubular and spindle cell carcinoma
- Neuroblastoma-associated RCC
Unclassified renal cell carcinoma: Renal cell cancers are termed as unclassified because the way they look doesn’t fit into any of the other categories or because there is more than one type of cancer cell present.
Other types of kidney cancers
Other types of kidney cancers include transitional cell carcinomas, Wilms Tumor, and renal sarcomas.
Transitional cell carcinoma: Of every 100 cancers in the kidney, 5% to 10% of RCCs are transitional cell carcinomas (TCCs), also known as urothelial carcinomas.
Transitional cell carcinomas don’t start in the kidney itself, but in the lining of the renal pelvis (where the ureters meet the kidneys). This lining is made up of cells called transitional cells that look like the cells that line the ureters and bladder.
Cancers that develop from these cells look like other urothelial carcinomas, such as bladder cancer, when looked at closely in the lab. Like bladder cancer, these cancers are often linked to cigarette smoking and being exposed to certain cancer-causing chemicals in the workplace.
Patients with transitional cell carcinomas (TCC) often have the same signs and symptoms as people with renal cell cancer − blood in the urine and, sometimes, back pain.
Wilms Tumor (nephroblastoma): Wilms Tumor almost always occur in children. This type of cancer is very rare among adults.
Renal sarcoma: Renal sarcomas are a rare type of kidney cancer that begin in the blood vessels or connective tissue of the kidney. They make up less than 1% of all kidney cancers.
Signs and Symptoms of Kidney Cancer
In the early stages kidney cancer usually doesn’t have signs or symptoms. As the diseases advances following are the common signs and symptoms that may develop:
- Blood in the urine, which may appear pink, red or cola colored
- Fatigue and tiredness
- Fever
- Pain in the back
- Loss of appetite
- Unexplained weight loss
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections.
We have samples available are cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Our company Bay Biosciences maintains and manages its own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.
Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data.
This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information.
Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases.
This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved at – 80°C.
Including fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor-made collection protocols.
Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:
- Peripheral whole-blood,
- Amniotic fluid
- Bronchoalveolar lavage fluid (BAL)
- Sputum
- Pleural effusion
- Cerebrospinal fluid (CSF)
- Serum (sera)
- Plasma
- Peripheral blood mononuclear cells (PBMC’s)
- Saliva
- Buffy coat
- Urine
- Stool samples
- Aqueous humor
- Vitreous humor
- Kidney stones (renal calculi)
- Other bodily fluids from most diseases including cancer.
We can also procure most human bio-specimens and can-do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquots from us.
Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
日本のお客様は、ベイバイオサイエンスジャパンBay Biosciences Japanまたはhttp://baybiosciences-jp.com/contact/までご連絡ください。