Bay Biosciences provides high quality, clinical grade FFPE tumor tissue block samples with matched sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid  specimens from patients diagnosed with Non-Hodgkin’s lymphoma.

Moreover, the serum, plasma and PBMCs are centrifuged from patient’s peripheral whole-blood using customized processing protocols.

In addition,the human bio-specimens are collected from unique Non-Hodgkin’s lymphoma patients and provided to a valued pharmaceutical customer for research, development and drug discovery.

Lymphoma Overview

Lymphoma is a type of blood cancer that develops when white blood cells called lymphocytes grow out of control. Specifically, lymphocytes are part of the immune system. In fact, they travel around the body in the lymphatic system and blood, helping you fight infections.

Moreover, there are two types of lymphocytes:

  • First, T Lymphocytes (T cells)

  • Second, B lymphocytes (B cells) 

In addition, lymphoma is a type of cancer of the lymphatic system, which is part of the body’s germ-fighting network. Notably, lymphoma begins in infection-fighting cells of the immune system called lymphocytes.

These cells are in the lymphatic system, which includes the lymph nodes, spleen, thymus, bone marrow, and other organs throughout the body. Consequently, in patients suffering from lymphoma, lymphocytes change and grow out of control.

Furthermore, there are two main types of lymphoma:

  • First, Non-Hodgkin’s

  • Second, Hodgkin’s

Non-Hodgkin’s Lymphoma

Non-Hodgkin’s lymphoma originates in the lymphatic system, the disease-fighting network spread throughout the body. In non-Hodgkin’s lymphoma, lymphocytes, which are a type of white blood cell, develop into tumors.

Furthermore, non-Hodgkin’s lymphoma is more common than Hodgkin lymphoma, the other general type of lymphoma. Additionally, many different subtypes of non-Hodgkin’s lymphoma exist. For instance, diffuse large B-cell lymphoma and follicular lymphoma are among the most common subtypes.

Follicular Lymphoma

Specifically, follicular lymphoma is a common type of slow-growing (low-grade) non-Hodgkin’s type of lymphoma, originating in the B lymphocytes, or B-cells. Moreover, it is the most common form of slow-growing disease, which can develop in any part of the body, causing symptoms like swollen lymph nodes.

It is called ‘follicular’ lymphoma because, in fact, the abnormal B cells usually develop in clumps called ‘follicles’ inside lymph nodes. Consequently, patients who suffer from follicular lymphoma don’t usually experience strong or obvious symptoms for a long time before diagnosis due to the indolent nature of this lymphoma.

Notably, the progression of the disease depends on many factors; however, it is usually not a threat to patients’ lives until it is in an advanced stage, which can take years.

Finally, follicular lymphoma affects mostly the lymph nodes, similar to other lymphomas, and under the microscope.

Notably, nearly all patients who suffer from follicular lymphoma have a BCL-2 mutation and translocation between the 14 and 18 chromosomes.

Consequently, alterations that result in abnormally high production of the BCL2 protein, which is responsible for the apoptosis or the natural life and death cycle of the cells.

Signs and Symptoms of Follicular Lymphoma

Follicular lymphoma is usually very slow-growing so signs and symptoms develop gradually over time. Many people have few symptoms and some have none at all. Sometimes follicular lymphoma is noticed during tests for a different health issue. However, follicular lymphoma can be very variable and some people might have faster-growing follicular lymphoma that causes more symptoms. Common symptoms of FL include enlargement of the lymph nodes (lumps), often, patients with Follicular Lymphoma have no obvious symptoms of the disease at diagnosis.

Enlargement of lymph nodes in the:

  • Neck
  • Underarms
  • Abdomen
  • Groin

Other symptoms include:

Causes of Follicular Lymphoma

Exact causes of follicular and other non-Hodgkin’s lymphomas are unknown. In contrast, unlike some cancers, they do not pass down in families. For instance, in some cases, radiation or cancer-causing chemicals, or certain infections, may cause it.
However, other times there is no known cause. Moreover, you are more likely to get follicular lymphoma as you age. Specifically, people are 60 years old, on average, when diagnosed.
Additionally, patients are also more likely to get the disease if they have HIV, rheumatoid arthritis, lupus , or celiac disease, which are all immune system disorders.

Types of Follicular Lymphoma

Generally speaking, most patients who have follicular lymphoma do not have a particular type. Nevertheless, there are some rare variants of follicular lymphoma that behave, and are treated, differently; these include:

  • Duodenal-Type Follicular Lymphoma
  • Pediatric-Type Follicular Lymphoma.

Duodenal-Type Follicular Lymphoma

To elaborate, Duodenal-Type Follicular Lymphoma grows in the small intestine, either small bowel or the gut.
Notably, it is slow growing and is usually diagnosed at an early stage. Consequently, duodenal-type follicular lymphoma is unlikely to spread (metastasize) to other parts of the body or change (transform) into a faster-growing type of lymphoma.
Therefore, patients with duodenal-type follicular lymphoma might be actively observed, treated with rituximab, on its own or with chemotherapy, or alternatively, treated with radiotherapy. Treatment is usually very successful.

Pediatric-Type Follicular Lymphoma

Pediatric-Type Follicular Lymphoma is a very rare form of follicular lymphoma. It typically affects children but it occasionally develops in adults. It is more common in males than females. Pediatric-type follicular lymphoma most commonly develops in lymph nodes in the head or neck. It is typically diagnosed at an early stage and is usually cured with treatment. Most patients have surgery to remove the affected lymph nodes. Occasionally, some patients need radiotherapy or chemotherapy. Pediatric-type follicular lymphoma does not usually come back (relapse) after successful treatment.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.