Bay Biosciences provides high quality, clinical grade fresh frozen bio-specimens, cryogenically preserved sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with Myasthenia Gravis (MG) disease.
The sera (serum), plasma and PBMC biofluid specimens are processed from patient’s peripheral whole-blood using customized collection and processing protocols. The myasthenia gravis bio-specimens are collected from unique patients diagnosed with myasthenia gravis and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.
Detailed clinical data, myasthenia gravis patients history, symptoms, complete blood count (CBC), elevated biomarker levels, genetic and metabolic information, histopathological findings, annotations associated with myasthenia gravis specimens is provided to a valued customer for research, development and drug discovery. The myasthenia gravis sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid are processed from patients peripheral whole-blood using customized collection and processing protocols.
Myasthenia Gravis (MG) Overview
Myasthenia gravis (MG) is a neuromuscular disease that causes weakness in the skeletal muscles, which are the muscles the body uses for movement. It occurs when communication between nerve cells and muscles becomes impaired. This impairment prevents crucial muscle contractions from occurring, resulting in muscle weakness.
According to the Myasthenia Gravis Foundation Of America approximately 36,000 to 60,000 cases of myasthenia gravis are estimated in the United States. However, as myasthenia gravis often remains underdiagnosed, the prevalence of myasthenia gravis disease is most likely higher.
Myasthenia gravis is a rare long-term condition that causes muscle weakness. It most commonly affects the muscles that control the eyes and eyelids, facial expressions, chewing, swallowing and speaking. But it can affect most parts of the body. Myasthenia gravis (MG) disease can occur regardless of race, gender and age. Myasthenia gravis typically starting in women under 40 and men over 60. Myasthenia gravis disease is not thought to be directly inherited nor contagious, but may occur in more than one member of the same family. It is not transmitted via intimate or any form of human contact There is no known cure for myasthenia gravis, but there are many effective treatments available that can make managing life with myasthenia gravis easier.
Signs and Symptoms of Myasthenia Gravis (MG)
Major symptom of myasthenia gravis (MG) disease is weakness in the voluntary skeletal muscles, which are muscles under your control. The failure of muscles to contract normally occurs because they can’t respond to nerve impulses. Without proper transmission of the impulse, the communication between nerve and muscle is blocked and weakness results. Weakness associated with myasthenia gravis (MG) disease typically gets worse with more activity and improves with rest.
Following are the common signs and symptoms of myasthenia gravis (MG) disease:
- Difficulty speaking
- Difficulty walking up stairs or lifting objects
- Facial paralysis
- Trouble breathing due to muscle weakness
- Problems with swallowing or chewing
- Fatigue
- Hoarseness in voice
- Drooping of eyelids
- Double vision
Causes of Myasthenia Gravis (MG)
Myasthenia gravis disease is an autoimmune disease, which means it’s the result of the immune system (the body’s natural defense against infection) mistakenly attacking a healthy part of the body. In an autoimmune condition, antibodies, which are proteins that normally attack foreign, harmful substances in the body, attack the neuromuscular junction. Damage to the neuromuscular membrane reduces the effect of the neurotransmitter substance acetylcholine, which is a crucial substance for communication between nerve cells and muscles. This results in muscle weakness.
Myasthenia gravis is caused by a problem with the signals sent between the nerves and the muscles. In myasthenia gravis, the immune system damages the communication system between the nerves and muscles, making the muscles weak and easily tired. It’s not clear why this happens, but it’s been linked to issues with the thymus gland (a gland in the chest that’s part of the immune system). Most patients with myasthenia gravis disease have a thymus gland that’s larger than normal. Around one in ten people have an abnormal growth of the thymus called a thymoma.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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