Bay Biosciences provides high quality, clinical grade, biopsy tissue samples, FFPE tissue blocks with matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with nonalcoholic steatohepatitis (NASH).
The sera (serum), plasma and PBMC biofluid specimens are processed from nonalcoholic steatohepatitis (NASH) patient’s peripheral whole-blood using customized collection and processing protocols. The nonalcoholic steatohepatitis (NASH) tissue and matched biofluid samples are collected from unique patients diagnosed with nonalcoholic steatohepatitis (NASH) and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.
Detailed clinical data, patient’s history, symptoms, complete blood count (CBC), serology, MRI, biopsy tissue findings, histopathology information, elevated biomarker levels, genetic and metabolic information associated with nonalcoholic steatohepatitis (NASH) specimens is provided to a valued customer for research, development and drug discovery.
The nonalcoholic steatohepatitis (NASH) sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluids are processed from patients peripheral whole-blood using customized collection and processing protocols.
Nonalcoholic Steatohepatitis (NASH) Overview
Nonalcoholic steatohepatitis (NASH) is liver inflammation and damage caused by a buildup of fat in the liver. It is part of a group of conditions called nonalcoholic fatty liver disease. You may be told you have a “fatty liver.” Many people have a buildup of fat in the liver, and for most people it causes no symptoms and no problems. But in some people, the fat causes inflammation and damages cells in the liver. Because of the damage, the liver doesn’t work as well as it normally should.
NASH can get worse and cause scarring of the liver, which leads to cirrhosis. But the disease doesn’t always get worse. NASH is similar to the kind of liver disease that is caused by long-term, heavy drinking. But NASH occurs in patients who don’t abuse alcohol. Patients with NASH develop progressive fibrosis in 25%-50% of individuals over 4-6 years, while 15-25% of individuals with NASH can progress to cirrhosis. In another study, 13 % of NASH patients with mild to moderate fibrosis (stage 1-2) and 50% of patients with fibrosis stage 3 developed cirrhosis.
Signs and Symptoms of Nonalcoholic Steatohepatitis (NASH)
In most early stages nonalcoholic steatohepatitis (NASH) cases, there are no noticeable symptoms. Most patients who have nonalcoholic steatohepatitis (NASH) feel fine and don’t know that they have the disease. Following are the signs and symptoms when nonalcoholic steatohepatitis (NASH) progresses and liver damage gets worse:
- Pain in the upper right side of the abdomen
- Fatigue (feeling tired all the time)
- Weight loss for no clear reason
- General weakness.
- Enlarged liver or spleen (usually observed by a doctor during an exam)
- Ascites, or swelling in the belly
- Jaundice or yellowing of the skin and eyes
Causes of Nonalcoholic Steatohepatitis (NASH)
Exact causes of why some people with a buildup of fat in the liver get nonalcoholic steatohepatitis (NASH) and some don’t are unknown. It could be that something in the environment triggers the inflammation in these patients. It could also be a inherited disorder which runs in their families.
Things that put people at risk for nonalcoholic steatohepatitis (NASH) and for liver damage include:
- Obesity
- Insulin resistance and type 2 diabetes
- High cholesterol and high triglycerides
- Metabolic syndrome
Most patients who have nonalcoholic steatohepatitis (NASH) are 40 to 50 years old and have one or more of the problems listed above. But NASH disease can develop in patients who have none of these risk factors.
Diagnosis of Nonalcoholic Steatohepatitis (NASH)
There is no single test that can diagnose nonalcoholic steatohepatitis (NASH). Following are some of the diagnostics tests used to see if fat is building up in the liver and to rule out other diseases:
- Blood tests (CBC)
- Abdominal ultrasound
- CT scan
- MRI scan
In addition to the above tests, a a liver biopsy may also be performed to be sure that you have NASH. In a liver biopsy, your doctor takes a sample of tissue from your liver and checks it for signs of NASH. NASH is diagnosed by the histological examination of a liver biopsy showing steatosis with concomitant inflammation and hepatocyte injury (hepatocyte ballooning).
Treatment of Nonalcoholic Steatohepatitis (NASH)
Treatment for nonalcoholic steatohepatitis (NASH) includes managing conditions that increase your risk for NASH or make it worse. You can:
- Reduce your total cholesterol level
- Reach a healthy weight. Losing 3% to 10% of your total body weight can make a difference
- Control diabetes
- Quit Smoking
- Stop or cut back on drinking alcohol
- Exercise regularly
Also, consult with your doctor or pharmacist about all the medicines you are taking. Some medications may harm your liver. In some cases, your doctor may suggest medicine to control or reverse liver damage caused by nonalcoholic steatohepatitis (NASH).
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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