Bay Biosciences provides high quality, clinical grade, biopsy tissue samples, FFPE  tissue blocks with matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with neuroendocrine prostate cancer (NEPC).

The sera (serum), plasma and PBMC biofluid specimens are processed from neuroendocrine prostate cancer (NEPC) patient’s peripheral whole-blood using customized collection and processing protocols.

Biopsy tissue and matched biofluid samples are collected from unique patients diagnosed with neuroendocrine prostate cancer (NEPC) and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.

Detailed clinical data, patient’s history, complete blood count (CBC), serology, MRI, biopsy tissue findings, histopathology information, elevated biomarker levels, genetic and metabolic information associated with neuroendocrine prostate cancer (NEPC) specimens is provided to a valued customer for research, development and drug discovery.

 

Neuroendocrine Prostate Cancer (NEPC) Overview

Neuroendocrine prostate cancer (NEPC) is, indeed, an aggressive variant of prostate cancer that may arise from the start in patients previously treated with hormonal therapies for prostate adenocarcinoma as a mechanism of resistance.

The prostate, specifically, is a small gland about the size of a walnut that sits between the bladder and the penis, just in front of the rectum. Furthermore, the urethra, which is the tube through which urine is passed, runs through the prostate.

Additionally, the prostate produces seminal fluid, which helps to feed and protect sperm. During ejaculation, the prostate, consequently, secretes this fluid into the urethra, where it mixes with sperm and is expelled through the penis as semen.

Moreover, NEPC cancers are rare; in fact, less than 2% of all prostate cancers are NEPC, and they are usually associated with aggressive disease, being more likely to be neuroendocrine carcinoma than neuroendocrine tumor.

Diagnosis

Furthermore, it is difficult to accurately diagnose and distinguish it from prostate cancer without pathology investigation and expert review of cells under a microscope. Approximately 1% of all of the cells within the prostate gland are neuroendocrine in origin.

Therefore, it is not unusual to see some neuroendocrine presence in a prostate cancer sample.

It is, therefore, vital to begin with establishing not only the number of neuroendocrine cells within the sample (and whether they are abnormal, i.e., cancerous) but also how many there are in comparison to prostate cancer cells.

Additionally, Neuroendocrine Prostate Cancer (NEPC) may arise de novo (that is, without a previous history of prostate cancer) or develop in the later stages of castration-resistant prostate cancer following previous hormone or taxane-based therapy, which results in treatment-emergent Neuroendocrine Prostate Cancer (t-NEPC).

Furthermore, NEPC and t-NEPC are less likely to express prostate-specific antigen (PSA). however, the PSA test may be useful in helping to diagnose and to direct treatment.

 

Causes of Neuroendocrine Prostate Cancer (NEPC)

Exact causes of  developing neuroendocrine cancer are unknown, however it is important to follow advice in leading a healthy lifestyle: eat healthily, exercise and avoid smoking and drinking too much alcohol.

Most Neuroendocrine Cancers do not run in families, however, a number of rare conditions may increase the risk of developing NECP. Therefore, if other members of the family have been diagnosed with cancer, or have a known genetic condition.

Signs and Symptoms of Neuroendocrine Prostate Cancer (NEPC)

Signs and symptoms, if they occur, maybe similar to those experienced by someone with an enlarged prostate, a bladder infection and/or suspected prostate cancer:

  • Urge to urinate frequently at night specially during night time
  • Weak or interrupted urine flow or the need to strain to empty the bladder
  • Erectile dysfunction
  • Pain and discomfort when sitting, usually casued by enlarged prostate gland
  • Blood in the urine (hematuria)
  • Blood in the seminal fluid
  • Pain or burning sensation during urination.

Following are other, possible signs and symptoms of late stage NECP cancer::

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC Samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human bio-fluids from diseased and normal healthy donors which includes:

  • Firstly, peripheral whole-blood
  • Secondly, amniotic fluid
  • Thirdly, bronchoalveolar lavage fluid (BAL)
  • Next, sputum
  • Also, pleural effusion
  • Moreover, cerebrospinal fluid (CSF)
  • Likewise, serum (sera)
  • In addition, plasma
  • Moreover, peripheral blood mononuclear cells (PBMC) 
  • Furthermore, saliva
  • Next, buffy coat
  • Accordingly, urine
  • For example, Stool samples
  • Also, aqueous humor
  • And, vitreous humor
  • Lastly, kidney stones (renal calculi)
  • Finally, other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols. you buy donor-specific collections in higher volumes and specified sample aliquots from us in multiple format and sets.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.