Neuromuscular Disorders Samples

Bay Biosciences provides high-quality biopsy tissue samples, FFPE blocks with matched fresh frozen sera (serum),  plasma, and peripheral blood mononuclear cells (PBMC) bio-fluids from patients diagnosed with neuromuscular disorders.

Moreover, the sera (serum), plasma and PBMCs are processed from neuromuscular disorders patient’s blood using customized collection and processing protocols.

In addition, the matched bio-fluids are collected from unique patients with neuromuscular disorders and are provided to a valued pharmaceutical customer for research, development and drug discovery.

Neuromuscular Disorders Overview

In fact, neuromuscular disorders are usually acquired or inherited, genetic conditions that affect some part of the neuromuscular system.

Moreover, neuromuscular disorders mostly tend to be progressive in nature, and result in muscle weakness and fatigue. Furthermore, some neuromuscular disorders are present at birth in patients, some manifest in childhood, and others have an adult onset.

In addition, neuromuscular disorders may be genetically passed down or due to a spontaneous genetic mutations. Moreover, or may be due to an abnormal immune response, inflammation, poisoning, toxins or tumors. Furthermore, some of the neuromuscular disorders don’t have any known cause.

Following are some of the categories of Neuromuscular:

  • Muscular dystrophies: These involve the structure of the muscle cells
  • Peripheral motor neuron diseases: These involve muscle-controlling nerve cells of the arms, legs, neck and face
  • Motor neuron diseases: These involve nerve cells in the spinal cord
  • Neuromuscular junction diseases: These involve the site where nerves and muscles meet
  • Myopathies: These involve tone and contraction of muscles controlling voluntary movements; may include inflammation of muscles or related tissues
  • Metabolic diseases of the muscle: These involve errors in metabolism in producing energy in the muscle cells.

Signs and Symptoms of Neuromuscular Disorders

Signs and symptoms of muscle disease may include muscular weakness, rigidity, loss of muscular control, numbness, tingling, twitching, spasms, muscle pain and certain types of limb pain.

Although muscle wasting is not painful, the resulting weakness can cause cramping, stiffness, joint deformities, chronic aches and pain, and sometimes the tightening and freezing of joints, which is known as contracture.

Diagnosis of Neuromuscular Disorders

Diagnosing a neuromuscular disorder starts with direct clinical observation, which can identify atrophy or loss of muscle bulk and/or tone. Blood tests can determine abnormal levels of various chemicals and antigens in the blood common in certain neuromuscular  diseases. Electromyography, commonly referred to as EMG, can assess the health of muscles and motor neuron nerve cells that control those muscles. EMG results are used to help diagnose or rule out a number of neuromuscular disorders.

Treatment of Neuromuscular Disorders

Most neuromuscular disorders do not have an effective cure available, but some neuromuscular disorders can be effectively managed and treated. Following are some of the common treatments available for neuromuscular disorders:

Drug Therapy: Immunosuppressive drugs can treat certain muscle and nerve diseases and diseases of the nerve-muscle junctions. Anticonvulsants and antidepressants may be used to treat the pain of neuropathy.

Referrals to appropriate specialists: Patients may receive referrals to surgeons for neurological surgery, thoracic surgery, orthopedic surgery or other types of surgery. They may also refer patients to physical, occupational, speech or rehabilitation specialists; physiatrists; pulmonary medicine specialists or ophthalmologists depending on the condition of the patient.

Patient and family education and counseling: In addition to individual and family sessions, treatment may include referral to appropriate support groups or genetic counselors. Further testing and specialists, such as physical therapists and nutritionists, may evaluate patients as needed.

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC) and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, researchers find patient’s data extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

  • Firstly, Peripheral whole-blood
  • Secondly, Amniotic fluid
  • Third, Bronchoalveolar lavage fluid (BAL)
  • Moreover, Sputum
  • Furthermore, Pleural effusion
  • Next, Cerebrospinal fluid (CSF)
  • Also, Serum (sera)
  • Likewise, Plasma
  • In addition, Peripheral blood mononuclear cells (PBMC)
  • For example, Saliva
  • Also, Buffy coat
  • Moreover, Urine
  • Furthermore, stool samples
  • Next, Aqueous humor
  • Likewise, Vitreous humor
  • Lastly, Kidney stones (renal calculi)
  • Finally, Other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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