Bay Biosciences provides Osteosarcoma tumor tissue samples FFPE blocks from unique pediatric patients. 

Moreover, detailed clinical annotations associated with the samples are provided to a valued pharmaceutical customer for research and drug discovery.

Osteosarcoma Overview

Osteosarcoma (also called osteogenic sarcoma) is the most common type of cancer that starts in the bones. Moreover, it occurs at the end of long bones, often around the knee. However, it can happen anywhere in the body.

Moreover, other sites for osteosarcoma include the upper leg, or thighbone, the lower leg, upper arm bone, or any bone in the body, including those in the pelvis, shoulder, and skull. In addition, osteosarcoma is a type of bone cancer that usually develops in the osteoblast cells that form bone.

Furthermore, the cancer cells in these tumors look like early forms of bone cells that normally help make new bone tissue; however, the bone tissue in an osteosarcoma is not as strong as that of normal bones.

Interestingly, most patients diagnosed with osteosarcoma are under the age of 25, and researchers think it occurs more often in males than females. In fact, osteosarcoma accounts for about 3% of cancers that happen in children.

Additionally, approximately 800 new case of osteosarcoma are reported each year in the United States. Most osteosarcomas, therefore, occur in children and young adults.

Consequently, teens are the most commonly affected age group, but osteosarcoma can develop at any age. Boys are more likely to have osteosarcoma than girls, and most cases of osteosarcoma involve the knee.

Causes of Osteosarcoma

The exact causes of osteosarcoma is unknown, but it is believed to be due to DNA mutations inside bone cells, either inherited or acquired after birth.

Risk Factors of Osteosarcoma

Osteosarcoma is most often seen in teenage boys. Teens diagnosed with osteosarcoma tend to be tall for their age, suggesting that rapid bone growth may lead to the disease. Kids who have inherited one of the rare cancer syndromes also are at higher risk for osteosarcoma. Following are the risk factors of Osteosarcoma:

  • Teenage growth spurts
  • Being tall for a specific age
  • Previous treatment with radiation for another cancer, especially at a young age or with high doses of radiation
  • Presence of certain benign (noncancerous) bone diseases

Presence of certain rare, inherited disorders, such as the following:

Signs and Symptoms of Osteosarcoma

Each individual Osteosarcoma patient may experience symptoms differently. Following are the most common symptoms of Osteosarcoma:

  • Pain in the affected bone
  • Swelling around the affected area
  • Increased pain with activity or lifting
  • Limping
  • Decreased movement of the affected limb

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Human biospecimens are available including cancer (tumor) tissue, cancer serum, cancer plasma, cancer peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors for controls, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.