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Ovarian Cancer Tumor Tissue Samples

by | Apr 4, 2019 | Updates | 0 comments

Bay Biosciences provides fresh frozen (-80°) ovarian cancer tumor tissue samples with matching clinical grade serum (sera), plasma and peripheral blood mononuclear cells (PBMC) samples processed from patient’s fresh whole-blood from unique patients diagnosed with Ovarian cancer.

Detailed clinical data and pathology annotations including patient’s corresponding diagnostic test values are provided to a valued pharmaceutical customer for research.

Ovarian Cancer Overview

The ovaries are two female reproductive glands that produce ova, or eggs. They also produce the female hormones estrogen and progesterone. Ovarian cancer is is when abnormal cells in the ovary begin to multiply out of control and form a tumor that affects the ovaries in women. Ovaries are the reproductive organs which produce eggs and they also produce hormones. Ovarian cancer may actually start in the tube adjacent to the ovary called the fallopian tube, which is the tube that carries the egg from the ovary to the uterus. If left untreated, the tumor can spread to other parts of the body.

In the United States around 21,750 are estimated in a year which accounts for 1.2% of all new cancer cases. It is estimated that 13,940 deaths were caused by Ovarian cancer accounting for 2.3% of all cancer deaths annually. Ovarian cancer often has warning signs, but the earliest symptoms are vague and easy to dismiss. 20% of ovarian cancers are detected at an early stage.

Signs and Symptoms of Ovarian Cancer

Early signs and symptoms symptoms of ovarian cancer are similar to other common illnesses or they tend to come and go. Following are the signs and symptoms of  ovarian cancer:

Ovarian cancer can also cause other symptoms, such as:

Types of Ovarian Cancer

The ovaries are made up of three types of cells, each cell can develop into a different type of tumor:

  • Epithelial tumors form in the layer of tissue on the outside of the ovaries. Most of ovarian cancers are epithelial tumors.
  • Stromal tumors tumors grow in the hormone-producing cells, some of ovarian cancers are stromal tumors.
  • Germ cell tumors develop in the egg-producing cells, germ cell tumors are rare.

Ovarian cysts

An ovarian cyst is a collection of fluid or air that develops in or around the ovary. Most ovarian cyst form as a normal part of ovulation, which is when the ovary releases an egg. They usually only cause mild symptoms, like bloating, and go away without treatment. Cysts are more of a concern if you aren’t ovulating. Women stop ovulating after menopause. If an ovarian cyst forms after menopause.

Risk Factors of Ovarian Cancer

The exact cause of ovarian cancer is unknown, however, the following factors can increase the risk of developing ovarian cancer:

Older age is another risk factor, most cases of ovarian cancer develop after menopause. It’s possible to have ovarian cancer without having any of these risk factors. Likewise, having any of these risk factors doesn’t necessarily mean you’ll develop ovarian cancer.

Diagnosis of Ovarian Cancer 

Ovaries are situated deep within the abdominal cavity, so patients are unlikely to feel a tumor. There’s no routine diagnostic screening available for ovarian cancer. That’s why it is important for to report unusual or persistent symptoms to your doctor. If the doctor suspects ovarian cancer, they’ll likely recommend a pelvic examination. Performing a pelvic exam can help your doctor discover irregularities, but small ovarian tumors are very difficult to feel. As the tumor grows, it presses against the bladder and rectum, doctors may be able to detect irregularities during a rectovaginal pelvic examination.

Following tests are conducted to determine and detect Ovarian cancer :

  • Transvaginal ultrasound(TVUS): TVUS is a type of imaging test that uses sound waves to detect tumors in the reproductive organs, including the ovaries. However, TVUS can’t help your doctor determine whether tumors are cancerous.
  • Abdomen/Pelvis CT Scan: If you’re allergic to dye, they may order a Pelvic MRI Scan
  • Blood test to measure cancer antigen 125 (CA-125) levels: A CA-125 test is a biomarker that’s used to assess treatment response for ovarian cancer and other reproductive organ cancers. However, menstruation, uterine fibroids, and uterine cancer can also affect CA-125 levels in the blood.
  • Biopsy: A biopsy involves removing a small sample of tissue from the ovary and analyzing the sample under a microscope.

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.

All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness. 

Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures. 

In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.

 

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