Bay Biosciences provides fresh frozen ovarian cancer tumor tissue samples with matching serum (sera), plasma with detailed clinical annotations to a pharmaceutical customer for research, development and discovery.

Ovarian Cancer Overview

The ovaries produce ova, or eggs, and also produce the female hormones estrogen and progesterone. Furthermore, ovarian cancer occurs when abnormal cells in the ovary begin to multiply out of control and form a tumor that affects the ovaries in women.

Additionally, ovaries serve as the reproductive organs that produce eggs and hormones. Moreover, ovarian cancer may actually start in the tube adjacent to the ovary called the fallopian tube, which carries the egg from the ovary to the uterus. If left untreated, the tumor can spread to other parts of the body.

In fact, in the United States, around 21,750 people are diagnosed with ovarian cancer each year, accounting for 1.2% of all new cancer cases. Furthermore, it is estimated that ovarian cancer causes 13,940 deaths annually, accounting for 2.3% of all cancer deaths.

Although ovarian cancer often has warning signs, the earliest symptoms are vague and easy to dismiss. Consequently, doctors detect 20% of ovarian cancers at an early stage.

Signs and Symptoms of Ovarian Cancer

Early signs and symptoms of ovarian cancer resemble those of other common illnesses; therefore, they tend to come and go.

Following are the signs and symptoms of ovarian cancer:

    • First, abdominal bloating, pressure, and pain
    • Additionally, abnormal fullness after eating (satiety);
    • Furthermore, difficulty eating;
    • An increase in urination; and an increased urge to urinate

Moreover ovarian cancer can also cause other symptoms, such as:

Types of Ovarian Cancer

The ovaries consist of three types of cells, each of which can develop into a different type of tumor.

  • Specifically, epithelial tumors form in the layer of tissue on the outside of the ovaries. In fact, most of ovarian cancers are epithelial tumors.
  • On the other hand, stromal tumors grow in the hormone-producing cells; consequently some of ovarian cancers are stromal tumors.
  • Additionally germ cell tumors develop in the egg-producing cells, however, germ cell tumors are rare.

Ovarian cysts

An ovarian cyst is a collection of fluid or air that develops in or around the ovary. In most cases, ovarian cyst form as a normal part of ovulation, which is when the ovary releases an egg. Typically, they usually only cause mild symptoms, like bloating, and go away without treatment.

Moreover, cysts are more of a concern if you aren’t ovulating. Women stop ovulating after menopause. If an ovarian cyst forms after menopause.

Causes of Ovarian Cancer

Doctors have identified things that can increase the risk of ovarian cancer; however, it’s not clear what causes it.

Moreover doctors know that, specifically, changes (mutations) in the DNA of cells in or near the ovaries cause ovarian cancer to begin. In fact, a cell’s DNA provides the instructions that tell the cell what to do.

Consequently, the changes instruct the cells to grow and multiply quickly, thereby creating a mass (tumor) of cancer cells. Furthermore, the cancer cells continue to live when healthy cells would die.

As a result, they invade nearby tissues and break off from an initial tumor to spread (metastasize) to other parts of the body.

Risk Factors of Ovarian Cancer

The exact cause of ovarian cancer is unknown, however, the following factors can increase the risk of developing ovarian cancer:

  • Family history of ovarian cancer
  • Genetic mutations of genes associated with ovarian cancer, such as BRCA1 or BRCA2
  • A personal history of breast, uterine or colon cancer
  • Obesity
  • Use of certain fertility drugs or hormone therapies
  • No history of pregnancy
  • Endometriosis

Furthermore, older age is another risk factor, as most cases of ovarian cancer develop after menopause. It’s important to note that it’s possible to have ovarian cancer without having any of these risk factors. Likewise, having any of these risk factors doesn’t necessarily mean you’ll develop ovarian cancer.

Diagnosis of Ovarian Cancer

Firstly, doctors find ovaries situated deep within the abdominal cavity; as a result, patients are unlikely to feel a tumor. Furthermore, there’s no routine diagnostic screening available for ovarian cancer. That’s why it is important to report unusual or persistent symptoms to your doctor. If the doctor suspects ovarian cancer, they’ll likely recommend a pelvic examination.

In this case, performing a pelvic exam can help your doctor discover irregularities, but small ovarian tumors are very difficult to feel. Moreover, as the tumor grows, it presses against the bladder and rectum, allowing doctors to detect irregularities during a rectovaginal pelvic examination.

Consequently, doctors conducts the following tests are conducted to determine and detect ovarian cancer:

  • Fots instance, Transvaginal ultrasound (TVUS): TVUS is a type of imaging test that uses sound waves to detect tumors in the reproductive organs, including the ovaries. However, TVUS can’t help your doctor determine whether tumors are cancerous.
  • In addition, Abdomen/Pelvis CT Scan: If you’re allergic to dye, they may order a Pelvic MRI Scan
  • Moreover, blood test to measure cancer antigen 125 (CA-125) levels: A CA-125 test is a biomarker that’s used to assess treatment response for ovarian cancer and other reproductive organ cancers. However, menstruation, uterine fibroids, and uterine cancer can also affect CA-125 levels in the blood.
  • Finally, Biopsy: A biopsy involves removing a small sample of tissue from the ovary and analyzing the sample under a microscope.

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

Customized Collections

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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