Bay Biosciences provides high quality, clinical grade fresh frozen human serum (sera), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples.

Moreover the samples are derived from patient’s whole-blood using customized sample processing protocols, from unique pancreatitis patients.

In addition detailed clinical data, serology, pathology, biomarkers, annotations associated with the Pancreatitis serum (sera), plasma and PBMCs are provided to a valued customer for research.

Pancreatitis Overview

Inflammation of the pancreas, in fact, characterizes pancreatitis. Situated behind the stomach and adjacent to the small intestine, the pancreas is, moreover, a large gland.

Enzymes are, consequently, released by the pancreas to aid in food digestion and to regulate glucose management in the body. Furthermore, powerful digestive enzymes are released into the small intestine to assist in food digestion. In addition, insulin  and glucagon are released into the bloodstream as well.

These hormones, in turn, play a crucial role in helping the body control its use of food for energy. Thus, pancreatitis may appear and disappear rapidly; however, it may also persist as a chronic issue.

Types of Pancreatitis

Following are the two types of Pancreatitis:

Acute Pancreatitis

Acute pancreatitis, on the other hand, is a condition characterized by sudden inflammation that lasts a short time. It can vary, for instance, from causing mild discomfort to being a severe, life-threatening illness.

The NIDDK reports that, consequently, approximately 275,000 hospital stays for acute pancreatitis occur each year in the United States. After receiving appropriate treatment, most patients with acute pancreatitis, as a result, experience complete recovery.

In severe instances, however, acute pancreatitis may lead to bleeding, serious tissue damage, infection, and the formation of cysts.

Additionally, severe pancreatitis can affect other vital organs, including, for example, the heart, kidneys, and lungs.

Chronic Pancreatitis

Long-lasting inflammation is what chronic pancreatitis is. In fact, it most often occurs after an episode of acute pancreatitis. Moreover, drinking excessive amounts of alcohol for an extended period is another leading cause. Consequently, symptoms may not appear for many years due to damage from high alcohol intake, but then, severe pancreatitis symptoms might suddenly emerge.

Long Lasting Condition

As a result, chronic pancreatitis constitutes a long-lasting condition. Specifically, the pancreas does not heal or improve or improve; instead, it worsens over time, potentially leading to lasting damage. Furthermore, cells that produce insulin, a hormone released by the pancreas that regulates sugar levels, can be damaged by pancreatitis.

Additionally, necrotizing pancreatitis can develop from severe cases of acute pancreatitis, which refers to the death of cells due to disease.

Notably, about 10 % of acute pancreatitis cases typically result in this condition when pancreatitis is left untreated. In particular, digestive enzymes can leak into the pancreas due to inflammation from pancreatitis. Ultimately, damage and death of the tissue can result from this, leading to necrotizing pancreatitis.

Signs and Symptoms of Pancreatitis

Most patients who have acute or chronic pancreatitis experience middle-left upper abdominal pain as their primary symptom. Furthermore, some people who have chronic pancreatitis may show inflammation on diagnostic imaging scans; however, they may otherwise show no symptoms.

In addition, other symptoms of pancreatitis may include:

Patients who have chronic pancreatitis may also experience steatorrhea, which is fatty stools that give off a foul odor. Steatorrhea can be a sign of malabsorption. This means you’re not getting all of your essential nutrients because your pancreas doesn’t secrete enough digestive enzymes to break down your food.

Causes of Pancreatitis

Following are the known causes of developing pancreatitis:

Gallstones

Acute pancreatitis is most commonly caused by gallstones. Specifically, small, solid masses form from bile, a fluid that aids in digestion, known as gallstones. At the junction where the main pancreatic duct and the common bile duct come together, consequently, a large gallstone can become lodged.

These ducts, in turn, empty into the duodenum, the first part of the small intestine. Moreover, digestive enzymes are carried from the pancreas by the pancreatic duct. Additionally, bile and other substances from the liver and gallbladder are carried by the common bile duct. As a result, a lodged gallstone can cause a backup of these substances, ultimately leading to inflammation of the bile duct and pancreas.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Human biospecimens are available including cancer (tumor) tissue, cancer serum, cancer plasma, cancer peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors for controls, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.