Bay Biosciences provides high quality, clinical grade fresh frozen human serum (sera), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples derived from patient’s whole-blood using customized sample processing protocols, from 30 unique treatment-naive patients diagnosed with Pancreatitis.
Detailed clinical data, serology, pathology, biomarkers, annotations associated with the Pancreatitis serum (sera), plasma and PBMC samples is provided to a valued customer for genomics, proteomics and biomarker research.
Pancreatitis Overview
Pancreatitis is a disease in which the pancreas becomes inflamed. The pancreas is a large gland located behind the stomach and next to the small intestine. It releases enzymes that help you digest food and also regulates how your body manages glucose. The pancreas releases powerful digestive enzymes into the small intestine to help digest the food. It releases insulin and glucagon into the bloodstream. These hormones help the body control how it uses food for energy. Pancreatitis can come and go quickly, or it can be a chronic problem.
Types of Pancreatitis
Following are the two types of Pancreatitis:
Acute Pancreatitis
Acute pancreatitis is sudden inflammation that lasts a short time. It can range from mild discomfort to a severe, life-threatening illness. According to the NIDDK each year, about 275,000 hospital stays for acute pancreatitis occur in the United States. Most patients with acute pancreatitis recover completely after getting the right treatment. In severe cases, acute pancreatitis can cause bleeding, serious tissue damage, infection, and cysts. Severe pancreatitis can also harm other vital organs such as the heart, kidneys and lungs.
Chronic Pancreatitis
Chronic pancreatitis is long-lasting inflammation. It most often happens after an episode of acute pancreatitis. Another top cause is drinking lots of alcohol for a long period of time. Damage to the pancreas from high alcohol intake may not cause symptoms for many years, but then you may suddenly have severe pancreatitis symptoms. Chronic pancreatitis is a long-lasting condition. The pancreas does not heal or improve. Instead, it gets worse over time, which can lead to lasting damage to the pancreas. Pancreatitis can damage cells that produce insulin, a hormone released by the pancreas that regulates the amount of sugar in your blood. This leads to diabetes in about 45 % of people with chronic pancreatitis.
Severe cases of acute pancreatitis can develop into necrotizing pancreatitis, which refers to the death of cells due to disease. This occurs in about 10 % of acute pancreatitis cases, typically when pancreatitis is left untreated. Inflammation from pancreatitis can cause digestive enzymes to leak into the pancreas. This can result in damage and death of the tissue, leading to necrotizing pancreatitis.
Signs and Symptoms of Pancreatitis
Most patients who have acute or chronic pancreatitis experience middle-left upper abdominal pain as their primary symptom. Some people who have chronic pancreatitis may show inflammation on diagnostic imaging scans, but otherwise may show no symptoms.
Other symptoms of pancreatitis may include:
- Pain that wraps around the upper body and involves the back in a band-like pattern
- Indigestion
- Nausea or vomiting
- Fatigue
- Abdominal tenderness
- Unintentional weight loss
- Diarrhea
- Bloating with a distended (swollen) abdomen
- Hiccups
- Fever
Patients who have chronic pancreatitis may also experience steatorrhea, which is fatty stools that give off a foul odor. Steatorrhea can be a sign of malabsorption. This means you’re not getting all of your essential nutrients because your pancreas doesn’t secrete enough digestive enzymes to break down your food.
Causes of Pancreatitis
Following are the known causes of developing pancreatitis:
- Autoimmune diseases
- Infections
- Gallstones
- High alcohol consumption
- Some medications
- Cystic Fibrosis
- Abdominal surgery
- Injury (trauma) to the belly
- Pancreatic Cancer
Gallstones are the most common cause of acute pancreatitis. Gallstones are small, solid masses that form from bile, a fluid that helps with digestion. A large enough gallstones can get stuck at the junction where the main pancreatic duct and the common bile duct come together. These ducts empty into the duodenum, the first part of the small intestine.
The pancreatic duct carries digestive enzymes from the pancreas. The common bile duct carries bile or other substances from the liver and the gallbladder. A stuck gallstones can cause a backup of these substances, leading to inflammation in both the common bile duct and the pancreas.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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