Bay Biosciences provides high quality, clinical grade peripheral blood mononuclear cells (PBMC) biofluid samples(PBMC) samples from untreated patients newly diagnosed with Celiac Disease.

Moreover the celiac diseaseSamples are processed under customized protocols provided by the researcher. 

Celiac Disease Overview

Celiac disease is a digestive disease that damages the small intestine because of a sensitivity to gluten, which exists in wheat, rye, barley, and oats. Moreover, this hereditary disorder interferes with the absorption of nutrients from food.

When patients with celiac disease eat foods containing gluten, consequently, their immune system responds by damaging the small intestine. Tiny fingerlike protrusions, called villi, which line the small intestine and enable the absorption of nutrients from food into the bloodstream, are lost. As a result, without these villi, malnutrition occurs, regardless of how much food a person consumes.

Gluten

Gluten is a composite of gliadin and glutenin, two proteins found in grains such as wheat, barley, and rye. In addition, these proteins help hold the grains together, providing the elasticity needed to make bread, pasta, and other foods.

Furthermore, some people have difficulty digesting the proteins and find that consuming gluten causes digestive problems, such as bloating and irritable bowel, along with other unpleasant GIT symptoms.

Foods Containing Gluten

Gluten exists in most foods that producers make using wheat, barley, or rye grain. In addition, it is not just present in bread and dough; manufacturers also include gluten in common foods like salad dressings, sauces, seasonings, and beer.

Therefore, if you’re trying to eliminate gluten from your diet, you’ll need to read labels carefully and remember to look for all the different ways manufacturers may list gluten on the label.

Furthermore, many popular gluten-free foods now have clear markings, which can help you find suitable alternatives. Moreover, you will easily find lots of information online about maintaining a gluten-free diet.

Allergy caused by Gluten

When someone says they’re allergic to gluten, this usually means they have celiac disease. Specifically, celiac disease is an autoimmune disorder that causes damage to the small intestine when gluten consumption triggers it. As a result, celiac disease patients will typically experience digestive problems along with other symptoms, like a skin rash or even seizures, when they eat foods containing gluten.

Alternatively, if you don’t have celiac disease but think your body may be sensitive to gluten, you can try eliminating gluten from your diet, then reintroducing it to see if symptoms subside or return.

Signs and Symptoms of Celiac Disease

Following are the common signs and symptoms of celiac disease:

Additional Symptoms

  • First, joint pain
  • Second, tingling and numbness in the legs
  • Moreover, delayed growth
  • Furthermore, fatigue
  • In addition, painful skin rash
  • Likewise, missed menstrual periods (which is linked to excessive weight loss)
  • Finally, tooth discoloration or loss of enamel

Causes of Celiac Disease

Patients genes combined with eating foods with gluten and other factors can contribute to developing celiac disease; however, the precise cause isn’t known. Additionally, infant-feeding practices, gastrointestinal infections, and gut bacteria might contribute as well.

Moreover, sometimes celiac disease activates after surgery, pregnancy, childbirth, viral infections, or severe emotional stress. Specifically, when the body’s immune system overreacts to gluten in food, the reaction damages the tiny, hair-like projections called villi that line the small intestine.

Consequently, villi absorb vitamins, minerals, and other nutrients from the food you eat. If the villi are damaged, patients can’t get enough nutrients, no matter how much they eat.

Diagnosis of Celiac Disease

Once patients complete their medical history and the physical examination is done, the following diagnostic tests may be performed to diagnose celiac disease:

  • Blood Tests: Blood work measures the level of antibodies to gluten. In fact, researchers have found that persons with celiac disease have higher than normal levels of certain antibodies in their blood. Thus, the immune system produces these antibodies in response to substances such as gluten that the body perceives as threatening.
  • Biopsy: To diagnose celiac disease, the doctor may remove a tiny piece of tissue from the small intestine to check for damage to the villi. During the procedure, the doctor eases a long, thin tube, called an endoscope, through the mouth and stomach into the small intestine. Subsequently, the medical team then takes a sample of tissue using instruments passed through the endoscope. Consequently, this procedure is considered the gold standard for diagnosis of celiac disease.

Treatment of Celiac Disease

In terms of treatment, your doctor will determine specific options for celiac disease based on several factors:

  • Firstly, the patient’s age, overall health, and medical history
  • Secondly, the extent of the disease
  • Additionally, the patient’s tolerance of specific medicines, procedures, or therapies
  • Moreover, expectations for the course of the disease
  • Finally, the patient’s opinion or preference

Importantly, a gluten-free diet is the only treatment for persons with celiac disease. Therefore, adhering to a gluten-free diet is a lifetime requirement, as eating any gluten will further damage the intestine.

For most celiac disease patients, eliminating gluten from their diet will not only stop symptoms but also heal intestinal damage that has already occurred, and prevent further damage.

Usually, celiac disease patients will see an improvement in symptoms within days of starting the diet; furthermore, within three to six months, doctors usually find the small intestine completely healed, with villi intact and working. However, for older patients, doctors may find that complete healing may take up to two years, and ultimately, patients may fully recover.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Human biospecimens are available including cancer (tumor) tissue, cancer serum, cancer plasma, cancer peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors for controls, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.