Pediatric Cancer Samples for Research

Bay Biosciences provides FFPE tumor tissue samples with matching (-80°) serumplasma, peripheral blood mononuclear cells (PBMC) biofluid samples with matching from unique pediatric cancer patients for research.

Pediatric Cancers

The types of cancers that occur most often in children are different from those seen in adults. The most common cancers of children are:

  • Leukemia
  • Brain and spinal cord tumors
  • Neuroblastoma
  • Wilms tumor
  • Lymphoma (including both Hodgkin and non-Hodgkin)
  • Rhabdomyosarcoma
  • Retinoblastoma
  • Bone cancer (including osteosarcoma and Ewing sarcoma)

Leukemia in Children

Many early symptoms of leukemia in children are also symptoms of common, less serious childhood illnesses. For instance, they can include flu-like illness, fatigue, lack of appetite, headachez, and frequent infections.

Furthermore, childhood leukemia represents about 24.9% of all new childhood cancer cases.

According to the National Cancer Institute in the United States, it is, in fact, the most common type of cancer in children and teens, accounting for 1 out of 3 cancers affecting this age group. Additionally, it affects more males than females, though not by a large margin.

Moreover slightly more common among Hispanic children and children who are white than among African American and Asian American children.

Early Signs of Leukemia in Children

The earliest signs of leukemia can be hard to spot. Moreover, they can also vary from child to child, as not all children with leukemia show the symptoms listed above.

Furthermore, many of the symptoms are common and can indicate a range of illnesses. Consequently, the doctor will perform various tests and assessments before making a diagnosis.

Therefore, if a parent or caregiver notices any of the symptoms above, it is best to take the child to a doctor as soon as possible. Ultimately, a prompt diagnosis can ensure that the child receives the right treatment quickly.

Frequent Infections

While children with leukemia have high white blood cell counts, but most of these cells are not functioning correctly. In fact, this is because abnormal cells replace healthy white blood cells.

Furthermore, white blood cells help protect the body by fighting off infections. Consequently, recurrent or persistent infections can indicate that a child does not have enough healthy white blood cells.

Bruising and Bleeding

Moreover, if a child bruises easily and experiences severe nosebleeds or bleeds from the gums, this may point to leukemia.

Furthermore, a child with this type of cancer will have a lack of platelets that help prevent bleeding.

Extreme Fatigue

Moreover, in rare cases, leukemia leads to very severe weakness and exhaustion that can result in slurred speech.

Specifically, this occurs when leukemia cells collect in the blood, causing the blood to thicken. Consequently, the blood may be so thick that circulation slows through small vessels in the brain.

Feeling Generally Unwell or Experiencing Frequent Headaches

Additionally, a child may not be able to describe their symptoms in detail, but they may appear to be generally ill. They may also experience frequent, unexplained headaches.

Therefore, when the cause of a child’s illness is unclear, make an appointment with a doctor.

Swelling

In a child with leukemia, swelling can affect various parts of the body, including:

  • In the abdomen, for example, when abnormal cells collect in the liver or spleen
  • Additionally, the lymph nodes, causing small lumps to form on the sides of the neck, in the underarms, or around the collarbone, where lymph nodes reside
  • Furthermore, in the face and arms, when pressure on a vein called the superior vena cava causes blood to pool in the area

Importantly, a child with swollen lymph nodes and no additional symptoms is more likely to have an infection than leukemia.

Moreover, tumors from other types of cancers are more likely to put pressure on the superior vena cava and lead to facial swelling. The swelling would be worse when a child wakes up, and it will improve throughout the day.

This is called superior vena syndrome and rarely occurs in cases of leukemia. Nevertheless, it can be life threatening and requires emergency care.

Lack of Appetite, Stomachache, and Weight loss

When Leukemia cells cause swelling in the liver, kidneys, or spleen, these organs can press against the stomach.

As a result, the result may be a feeling of fullness or discomfort, a loss of appetite, and subsequent weight loss.

Bone or Joint Pain

Specifically, if a child seems to be in pain and complains that their bones or joints are sore or achy, this can indicate childhood leukemia.

Moreover, when leukemia develops, the abnormal cells can collect close to the surface of the bones or inside joints.

Biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Samples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Also, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

So this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samplestumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serumplasma and PBMC.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

Moreover, we can also procure most human bio-specimens, special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasmaserum, and PBMC bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

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