Bay Biosciences provides high quality fresh frozen (-80), clinical grade serum and plasma samples from 50 unique chronic Angina patients requiring beta blockers, calcium channel blockers, ACE, anti-platelet, anticoagulants.

Moreover, detailed clinical data and pathology annotations, associated with the chronic angina patients, is provided to a valued pharmaceutical customer for clinical research.

 

Angina Overview

Angina occurs when, as a result, part of the heart does not receive enough oxygen. Specifically, it may feel like pain, squeezing, or pressure in the chest. Importantly, angina is not a disease but rather a symptom of another underlying condition.

In essence, angina is tightness, squeezing, pressure, or pain in the chest. It occurs when, consequently, an area of the heart muscle receives less blood oxygen than usual.

Furthermore, angina is not a disease but a symptom. Typically, ischemia usually narrows or blocks one or more of the coronary arteries, leading to angina. Moreover, it is often a symptom of coronary heart disease (CHD).

While alone angina is not life-threatening, it can resemble the symptoms of a heart attack; therefore, it is a sign of heart disease.

Consequently, receive medical attention if angina occurs unexpectedly, does not go away, or does not respond to rest or medication.

Types of Angina

There are several types of angina, including:

Stable Angina

Stable angina. In this case, stable angina occurs when the heart is working harder than usual — for instance, during exercise. Typically, it usually lasts around  5 minutes.

Notably, it has a regular pattern, and a person may experience it for months or years. In most cases, rest or medication often relieves the symptoms.

Unstable Angina

Unstable angina does not follow a regular pattern; in fact, it usually occurs during rest. Additionally, atherosclerosis mostly results in a blockage that prevents blood from reaching the heart.

Consequently, the pain lasts longer than 5 minutes and may worsen over time. Furthermore, rest and medication alone may not improve the symptoms.

Therefore, unstable angina can indicate the risk of a heart attack. As a result, anyone with unexpected angina should receive emergency care.

Microvascular Angina

 Moreover, microvascular angina can occur with coronary microvascular disease (MVD). This condition affects the smallest coronary arteries.

In addition to chest pain, a person may experience:

  • Fatigue and low energy
  • Sleep problems
  • Shortness of  breath

Notably, microvascular angina tends to be more persistent than stable angina. In fact, it often lasts longer than 10 minutes and sometimes longer than 30 minutes.

Variant Angina

 On the other hand, variant angina is rare. In fact, doctors sometimes call it Prinzmetal angina, and it can develop when the body is at rest, often around midnight or in the early morning.

During this time, a spasm occurs in the coronary arteries. For this reason, possible triggers include exposure to cold, stress, medicines, smoking, or cocaine use. Although it is a chronic condition, medication can help manage it.

Coronary Artery Disease

Coronary artery disease occurs when, as a result of atherosclerosis, the coronary arteries that deliver blood flow to the myocardium are affected. Moreover, coronary artery disease is the most common cause of death in the United States.

Furthermore, the atherosclerotic process in the coronary arteries may be silent; however, it can also lead to the development of symptoms from decreased oxygen supply to the myocardium. These symptoms are termed angina pectoris, which comes from the Latin term meaning “a strangling feeling in the chest.

In addition, angina is chest pain that is caused by reduced blood flow to the heart muscles. Although it’s not usually life-threatening, it serves as a warning sign that you could be at risk of a heart attack or stroke.

Signs and Symptoms of Angina

Chest pain is the most common symptom of Angina, chest pain caused by angina usually:

  • Occurs when the heart works harder, usually during physical exertion
  • Feels tight, dull or heavy, it may spread to the left arm, neck, jaw or the back
  • Doesn’t come as a surprise, and episodes of pain tend to be alike
  • It is triggered by physical exertion or stress
  • Usually stops within a few minutes of resting
  • Usually lasts a short time (5 minutes or less)
  • Is relieved by rest or medicine
  • May feel like gas or indigestion
  • May feel like chest pain that spreads to the arms, back, or other areas

Sometimes there might be other symptoms, like feeling sick or having shortness of breath.

Causes of Angina

Angina is usually caused by the arteries supplying blood to the heart muscles becoming narrowed by a build-up of fatty substances called atherosclerosis. Following factors can increase your risk of arteriosclerosis include:

  • Lack of exercise
  • Smoking
  • Older age
  • Family history of atherosclerosis or heart disease
  • Unhealthy diet

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Human biospecimens are available including cancer (tumor) tissue, cancer serum, cancer plasma, cancer peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors for controls, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.