Polymyalgia Rheumatica Samples for Research

Bay Biosciences provides high-quality, matched fresh frozen sera (serum),  plasma, and peripheral blood mononuclear cells (PBMC) bio-fluids from patients diagnosed with polymyalgia, rheumatica (PMR).

Moreover, the sera (serum), plasma and PBMC bio-fluids are processed from polymyalgia, rheumatica disease patient’s peripheral whole-blood using customized collection and processing protocols.

In addition, the matched bio-fluids are collected from unique patients with polymyalgia, rheumatica and are provided to a valued pharmaceutical customer for research, development and drug discovery.

Polymyalgia Rheumatica Overview

In fact, polymyalgia rheumatica is an inflammatory disease most commonly seen in older adults, usually causes pain and stiffness in the shoulders and upper back and the hip area. Polymyalgia rheumatica (PMR) is an inflammatory disorder that causes widespread aching, stiffness and flu-like symptoms. 

Moreover, polymyalgia literally means “many muscle pains.” Rheumatica means “changing” or “in flux.” It is more common in women than men and is seen more often in Caucasians than other races.

Furthermore, it typically develops by age 70 and is rarely seen in people younger than 50. PMR may last from one to five years; however, it varies from person to person. Approximately 15 percent of people with PMR develop a potentially dangerous condition called giant cell arteritis. 

In addition, polymyalgia rheumatica and temporal arteritis frequently affect people over age 50. Exact causes of Polymyalgia rheumatica disease is unknown. The average age of polymyalgia rheumatica patients is 70. These diseases are more common among women, and Caucasians are more likely to get these diseases than other ethnic groups.

Signs and Symptoms of Polymyalgia Rheumatica

Following are the common signs and symptoms of polymyalgia rheumatica. Usually polymyalgia rheumatica occur on both sides of the body and might include:

  • Aches or pain in your shoulders
  • Aches or pain in your neck, upper arms, buttocks, hips or thighs 
  • Jaw or facial soreness, especially with chewing
  • Severe headaches, which is the most common symptom of polymyalgia rheumatica
  • Scalp tenderness
  • Stroke
  • Stiffness in affected areas, particularly in the morning or after being inactive for a time
  • Limited range of motion in affected areas
  • Pain or stiffness in your wrists, elbows or knees 
  • Vision changes or distorted vision that’s caused by decreased blood flow to the eyes
PMR patients might also have more-general signs and symptoms, including:
  • Mild Fever
  • Feeling sick
  • Fatigue
  • A general feeling of not being well (malaise)
  • Loss of appetite
  • Poor appetite
  • Night sweats
  • Unintended weight loss
  • Depression

Causes of Polymyalgia Rheumatica

Exact cause of polymyalgia rheumatica is unknown. Two main factors appear to be involved in the development of this condition:

  • Genetics: Certain genes and gene variations might increase your susceptibility.
  • Environmental exposure: New cases of polymyalgia rheumatica tend to come in cycles, possibly developing seasonally. This suggests that an environmental trigger, such as a virus, might play a role. But no specific virus has been shown to cause polymyalgia rheumatica.

Giant Cell Arteritis

Polymyalgia rheumatica and an another disease known as giant cell arteritis have many similarities. Many patients who have one of these diseases also have symptoms of the other disease.

Giant cell arteritis results in inflammation in the lining of the arteries, most often the arteries are in the temples. Signs and symptoms include headaches, jaw pain, vision problems and scalp tenderness. If left untreated, this condition can lead to stroke or blindness.

Diagnosis of Polymyalgia Rheumatica

Under the new criteria developed by the American College of Rheumatology and The European League Against Rheumatism, patients of age 50 years and older can be classified as having PMR if they meet the following conditions:

  • Shoulder pain on both sides
  • Morning stiffness that lasts at least 45 minutes
  • High levels of inflammation measured by blood tests
  • Reported new hip pain
  • Absence of swelling in the small joints of the hands and feet, and absence of positive blood tests for rheumatoid arthritis

The new classification criteria may also help to evaluate existing treatments for polymyalgia rheumatica.  Everyone with polymyalgia rheumatica is typically tested for temporal arteritis. This, too, would start with the exam and listening to the patient’s symptoms. If temporal arteritis is suspected, but less convincing features are present, a temporal artery biopsy may confirm the diagnosis. The biopsy is taken from a part of the artery located in the hairline, in front of the ear. In most cases the biopsy is helpful, but in some individuals it may be negative or normal, even though the person does have temporal arteritis.

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC) and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, researchers find patient’s data extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

  • Firstly, Peripheral whole-blood
  • Secondly, Amniotic fluid
  • Third, Bronchoalveolar lavage fluid (BAL)
  • Moreover, Sputum
  • Furthermore, Pleural effusion
  • Next, Cerebrospinal fluid (CSF)
  • Also, Serum (sera)
  • Likewise, Plasma
  • In addition, Peripheral blood mononuclear cells (PBMC)
  • For example, Saliva
  • Also, Buffy coat
  • Moreover, Urine
  • Furthermore, stool samples
  • Next, Aqueous humor
  • Likewise, Vitreous humor
  • Lastly, Kidney stones (renal calculi)
  • Finally, Other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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