Bay Biosciences supplies researchers with fresh frozen serumplasma, peripheral blood mononuclear cells (PBMC) biofluid samples and matching FFPE blocks from unique patients diagnosed with prostate cancer, therefore facilitating research, development, and discovery.

Prostate Cancer Overview

Doctors most commonly diagnose prostate cancer as the most prevalent cancer in males worldwide. Specifically, in the United States, the American Cancer Society (ACS) estimates that 268,490 men will receive a new diagnosis of this condition in 2022.

Furthermore, the prostate is a small gland that sits in a man’s lower abdomen, located under the bladder and surrounding the urethra. In addition, the body regulates the prostate with the hormone testosterone.

Moreover, the prostate gland produces seminal fluid, also known as semen. Thus, semen is the substance containing sperm that exits the urethra during ejaculation.

When an abnormal, malignant growth of cells — which we call a tumor — forms in the prostate, we refer to it as prostate cancer. Consequently, this cancer can spread to other areas of the body. In these cases, because the cancer consists of cells from the prostate, we still refer to it as prostate cancer.

Types of Prostate Cancer

Almost all cases of prostate cancer are a type of cancer called adenocarcinoma that grows in the tissue of a gland, such as the prostate gland. However, in addition, other rare types of cancer can also originate in the prostate, including:

Moreover, doctors categorize prostate cancer by how fast it grows. Specifically, it has two types of growth:

  • Aggressive, or fast-growing
  • Non-aggressive, or slow-growing

With non-aggressive prostate cancer, the tumor

tumor grows slowly. On the other hand, with aggressive cancer, the tumor can overgrow and, subsequently, spread to other body areas, such as the bones, and becomes a metastatic cancer.

Causes and Risk Factors of Prostate Cancer

Researchers have not identified a known cause for prostate cancer; however, they suggest that risk factors such as family history or age may increase your likelihood of developing the malignancy.

Who’s at risk?

While any man could develop prostate cancer, certain factors, therefore, raise the risk for the disease. These risk factors include:

  • A family history of prostate cancer
  • Certain ethnicities or race — for instance, African American males are at greater risk of having prostate cancer
  • Genentic changes 
  • Older age, 50 years of age or older
  • Obesity

Furthermore, some studies identify other risk factors like diet and chemical exposure that may increase your chances of diagnosis. However, the ACS states that those effects, nonetheless, remain unclear. Additionally, prostate cancer also occurs rarely in men under the age of 40.

Symptoms of Prostate Cancer

Some forms of prostate cancer are nonaggressive: therefore you may not have any symptoms. However, advanced prostate cancer often causes symptoms.

If you have any of the following signs or symptoms, don’t hesitate to contact your doctor. In addition, other conditions can cause some symptoms of prostate cancer, such as benign prostatic hyperplasia (BHP); consequently, you’ll need to check with your doctor to get a proper diagnosis.

Symptoms of prostate cancer can include urinary problems, sexual problems, and pain and numbness.

Urinary problems

Urinary problems: Doctors commonly observe urinary problems because the prostate is located beneath the bladder and surrounds the urethra. Because of this location, if a tumor grows on the prostate, it could press on the bladder or urethra and cause problems.

Urinary problems can include:

  • A stream that’s slower or weaker than normal
  • Bleeding while urinating
  • Frequent need to urinate

Sexual problems

Erectile dysfunction may be a symptom of prostate cancer. Also called impotence, this condition makes you unable to get and keep an erection.

Furthermore, blood in the semen after ejaculation can also be a symptom of prostate cancer.

Pain and numbness

Moreover, you may experience weakness or numbness in the legs and feet. You may also lose control of your bladder and bowel if cancer has spread, causing pressure on your spinal cord.

Diagnosis of Prostate Cancer

One of the best ways to detect cancer before any symptoms appear is to undergo a screening test. The earlier you find cancer, the easier it may be to treat.

Prostate-specific antigen (PSA)

PSA is a blood test that measures the number of prostate proteins in your blood. If the level is high, it may indicate prostate cancer.

The PSA test is a useful tool for your doctor to consider whether or not your PSA levels may indicate prostate cancer. Since early detection is crucial for treating cancer, this is a major benefit. The test is relatively simple and widely available for people with a prostate that want to be screened.

However, there are pros and cons to screening. For example, a 2018 stud found that PSA may increase your chances of early detection, but it doesn’t lessen your chances of dying from prostate cancer. The test has some associated concerns and it is important to discuss with your doctor what the risks of PSA screening would mean for you.

Other concerns to consider about PSA include:

  • Accuracy level
  • Overdiagnosis and overtreatment tendencies
  • Unclear overall benefit

Other factors can increase your PSA level, such as:

Digital rectal exam (DRE)

When you undergo a DRE, the doctor places their lubricated, gloved finger into your rectum to feel any bumps, rigid, or enlarged areas of the prostate.

Since prostate cancer often starts at the back of the gland, it may be detected using this method. Although not as effective as a PSA test, it is more effective among men who have an average PSA level but still have prostate cancer.

Prostate imaging

Using advanced imaging, such as magnetic resonance imaging (MRI) or ultrasound, you can detect prostate cancer. In a 2018 research article, experts indicated that you can now catch it earlier — and better identify its stage — with improved technologies.

Prostate biopsy

Sometimes, your doctor may recommend a prostate biopsy if they suspect cancer from an exam or find that you have an elevated PSA level.

During the biopsy, the doctor takes a small sample of your prostate tissue to analyze the cells. If they find the cells are cancerous, it can also help them determine how quickly they may spread and grow. To do this, they determine your Gleason score.

The Gleason score is an effective tool to predict your outlook, but it isn’t absolute. There are many other factors involved when predicting the spread and course of the disease, with experts varying in how they use the scoring system.

To be sure, the best way to determine your outlook depends on other predictors in addition to your Gleason scores, like your physical exam and tumor imaging.

Treatment of Prostate Cancer

Your doctor will develop an appropriate treatment plan for your cancer based on your age, health status, and the stage of your cancer.

For instance, if the cancer is nonaggressive, your doctor may recommend watchful waiting, also called active surveillance. Specifically, this means you’ll delay treatment but have regular checkups with your doctor to monitor cancer.

Moreover, if your doctor chooses to monitor cancer using active surveillance, they check your PSA every 6 months and perform an annual DRE. In addition, they may do a repeat biopsy and imaging in 1 to 3 years after the initial diagnosis.

Consequently, the doctor actively monitors your symptoms alone to decide if you need treatment when simply observing the disease. On the other hand, doctors may treat more aggressive types of cancer with other options, such as:

– Surgery
– Radiation
– Cryotherapy
– Hormone therapy
Chemotherapy
– Stereotactic radiosurgery

– Immunotherapy

Finally, if your cancer is very aggressive and has metastasized, there’s a good chance it has spread to your bones. In this case, for bone metastases, you may use the above treatments, in addition to others.

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samplestumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serumplasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

Customized Collections

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasmaserum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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