Bay Biosciences provides high quality, clinical grade, biopsy tissue samples, FFPE  tissue blocks with matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with Psoriasis.

Moreover, the serum, plasma and PBMCs are processed from psoriasis patient’s peripheral whole-blood using customized collection and processing protocols.

Furthermore, biopsy tissue and matched bio-fluid samples are collected from unique patients diagnosed with psoriasis and are provided to a valued pharmaceutical customer for research, discovery and drug development.

In addition, detailed clinical associated with psoriasis specimens is provided to a valued customer for research, development and drug discovery.

Psoriasis Overview

Psoriasis is an autoimmune disease that causes skin cells to multiply up to 10 times faster than normal. It causes inflammation in the body and makes the skin build up into bumpy red patches covered with white scales. Sometimes, these patches will crack and bleed. There may be visible signs of the inflammation such as raised plaques (plaques may look different for different skin types) and scales on the skin. 

Psoriasis usually appears in early adulthood, for most patients, it affects just a few areas. In some severe cases, psoriasis can cover large parts of the patients body. The patches can heal and then come back throughout a patient’s life. They can grow anywhere, but most appear on the scalp, elbows, knees, and lower back.

Types of Psoriasis

Following are the main type of psoriasis:

Pustular Psoriasis

Pustular psoriasis causes red and scaly skin with tiny pustules on the palms of the hands and soles of the feet. This type of psoriasis is more common in adults. It causes white, pus-filled blisters and broad areas of red, inflamed skin. Pustular psoriasis is typically localized to smaller areas of the body, such as the hands or feet, but it can be widespread.

Plaque Psoriasis

Plauque psoriasis is the most common type of psoriasis. According to the American Academy of Dermatology (AAD) about 80 percent of the psoriasis patients have plaque psoriasis. It causes red, inflamed patches that cover areas of the skin. These patches are often covered with whitish-silver scales or plaques. These plaques are commonly found on the elbows, knees, and scalp.

Guttate psoriasis

Guttate psoriasis which often starts in childhood or young adulthood, causes small, red spots, mainly on the arms, legs, torso and limbs. These spots are rarely thick or raised like plaque psoriasis. Triggers may be respiratory infections, strep throat, tonsillitis, stress, injury to the skin. Some antimalarial medicines and beta-blockers can also cause Gauttate psoriasis. 

Inverse Psoriasis

In patients with inverse psoriasis  bright areas of red, shiny, inflamed skin develops. These patches of inverse psoriasis develop under armpits or breasts, in the groin, or around skinfolds in the genitals.

Erythrodermic Psoriasis

Erythrodermic psoriasis is a severe and rare type of psoriasis. This form of psoriasis often covers large sections of the body at once. It causes fiery redness of the skin and shedding of scales in sheets. It is triggered by severe sunburn, infections, certain medications, and stopping some kinds of psoriasis treatment.  

Signs and Symptoms of Psoriasis

Psoriasis symptoms differ from patient to patient and depend on the type of psoriasis. Affected areas of psoriasis disease can be as small as a few flakes on the scalp or elbow, or cover the majority of the body. Not every psoriasis patient will experience all of these symptoms. Some patients will experience entirely different symptoms if they have a less common type of psoriasis.

Following are the common symptoms of psoriasis include:

  • Inflammed patches or rashes of red skin
  • Soreness around patches
  • Scaly plaques on the scalp 
  • Whitish-silver scales or plaques on the red patches
  • Dry itchy, painful skin that can crack or bleed
  • Small areas of bleeding where the involved skin is scratched
  • Problems with  fingernails and toenails, including discoloration and pitting; the nails may also begin to crumble or detach from the nail bed
  • Itching and burning sensations around patches
  • Painful swollen joints

Causes of Psoriasis

Exact causes of developing  psoriasis are unknown. Scientists believe that it’s a combination of factors that can cause psoriasis. It is believed that something with the immune system causes inflammation triggering new skin cells to form too quickly. Normally, skin cells are replaced every 10 to 30 days. With psoriasis, new cells grow every 3 to 4 days. The buildup of old cells being replaced by new ones creates the whitish silver scales.

Following are the factors that can trigger an outbreak of psoriasis:

  • Stress
  • Cuts, scrapes, or surgery
  • Strep infections
  • Certain blood pressure medications (Beta Blockers)
  • Antimalarial medications (Hydroxychloroquine)

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC Samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human bio-fluids from diseased and normal healthy donors which includes:

  • Firstly, peripheral whole-blood
  • Secondly, amniotic fluid
  • Thirdly, bronchoalveolar lavage fluid (BAL)
  • Next, sputum
  • Also, pleural effusion
  • Moreover, cerebrospinal fluid (CSF)
  • Likewise, serum (sera)
  • In addition, plasma
  • Moreover, peripheral blood mononuclear cells (PBMC) 
  • Furthermore, saliva
  • Next, buffy coat
  • Accordingly, urine
  • For example, Stool samples
  • Also, aqueous humor
  • And, vitreous humor
  • Lastly, kidney stones (renal calculi)
  • Finally, other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols. you buy donor-specific collections in higher volumes and specified sample aliquots from us in multiple format and sets.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.