Bay Biosciences provides high quality, clinical grade, biopsy tissue samples, FFPE blocks with matched cryogenically preserved sera (serum) and plasma biofluid samples from patients diagnosed with pulmonary fibrosis.

The sera (serum) and plasma biofluid specimens are processed from pulmonary fibrosis patient’s peripheral whole-blood using customized collection and processing protocols. The pulmonary fibrosis biopsy tissue and matched biofluid samples are collected from unique patients diagnosed with  pulmonary fibrosis and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.

Detailed clinical data, patient’s history, symptoms, complete blood count (CBC), serology, MRI, biopsy tissue findings, histopathology information, elevated biomarker levels, genetic and metabolic information associated with the pulmonary fibrosis specimens is provided to a valued customer for research, development and drug discovery.

The pulmonary fibrosis sera (serum), plasma and urine biofluids are processed using customized collection, processing and storage protocols.

Pulmonary Fibrosis (PF) Overview

Pulmonary fibrosis (PF) is a serious, lifelong lung disease. It causes lung scarring, tissues scar and thicken over time, making it harder to breathe. This thickened, stiff tissue makes it more difficult for the lungs to work properly.

Moreover,  pulmonary fibrosis (PF) is a form of interstitial lung disease that causes scarring in the lungs. There are over 200 different types of PF and in most cases, there’s no known cause. Symptoms may come on quickly or take years to develop. No cure exists. Medications may slow down scarring and help preserve lung function. Oxygen therapy and staying active may relieve symptoms.

Causes of Pulmonary Fibrosis (PF)

Several conditions can cause pulmonary fibrosis (scarring) of the lungs.

Interstitial Lung Disease

Firstly, interstitial lung disease involves inflammation of the air sacs or the web of tissue (interstitium) that surrounds them in the lungs. As a result, the inflammation can sometimes cause scar tissue to build up within the lungs, resulting in fibrosis.

Moreover, IPF is the most common type of interstitial lung disease. In particular, if doctors describe a condition as idiopathic, this means that they do not know exactly what causes it.

Typically, IPF appears between the ages of 50 and 70 years. Consequently, there are up to 207,000 people affected in the United States, and about 58,000 new cases are diagnosed each year.

Additionally, other risk factors for interstitial lung disease include:

  • Chemotherapy
  • Gastroesophageal reflux (GERD)
  • Older age
  • Previous viral infection or pneumonia
  • Radiation therapy to the chest cavity
  • Smoking
  • Tuberculosis (TB)
  • Xposure to asbestos or silica

Furthermore, in some cases, there may be a family history of the disease.

On the other hand, some people experience exacerbations, during which symptoms suddenly worsen. These episodes last for a while and then resolve. For instance, exposure to triggers, such as tobacco smoke, may cause a flare.

Symptoms and Complications of Pulmonary Fibrosis (PF)

The scarring of lung tissue makes it thick and stiff. Consequently, as the lung tissue thickens, it becomes increasingly difficult for the body to transfer oxygen from the lungs into the bloodstream. As a result, the brain and other organs may not receive enough oxygen.

Specifically, the symptoms depend on the amount of scarring and how much of the lung it affects, but they may include:

  • A persistent dry cough
  • Rounded and swollen fingertips and nails (clubbing)
  • Shortness of breath, especially during or after physical activity
  • Tiredness
  • Aching joints and muscles
  • Weight loss and loss of appetite

Moreover, scarring may also increase the risk of lung cancer.

In particular, idiopathic pulmonary fibrosis may present  symptoms that may not be noticeable at first; however, they tend to develop and worsen over time, making it increasingly difficult to breathe.

Ultimately, pulmonary hypertension or respiratory failure  can develop, both of which can be life-threatening because they prevent oxygen from reaching the body’s organs.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.