Bay Biosciences provides high-quality, fresh frozen biopsy tissue samples. FFPE  tissue blocks with matched fresh frozen sera (serum), plasma, and peripheral blood mononuclear cells (PBMC) bio-fluids from patients diagnosed with ROS1-Positive Lung Cancer.

The sera (serum), plasma and PBMC biofluid specimens are processed from ROS1-positive lung cancer patient’s peripheral whole-blood using customized collection and processing protocols.

Fresh frozen tissue and matched biofluid samples are collected from unique patients diagnosed with ROS1-positive lung cancer.

Bio-samples are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.

ROS1-Positive Lung Cancer Overview

ROS1 positive lung cancer is an aggressive form of lung cancer that often spreads quickly. New, targeted medications can help keep this type of lung cancer from progressing for a period of time, providing a better prognosis today compared to previous generations.

This type of ROS1-rearranged non-small cell lung cancer (NSCLC) is classified as a distinct molecular subset of NSCLC with a therapeutic target. ROS1 rearrangement is most often identified in never-smokers with adenocarcinoma and EGFR and ALK receptor tyrosine kinase inhibitors (TKIs).

Treatment with tyrosine kinase inhibitors (TKIs), which target the ROS1 kinase domain, is considered the standard of care. TKIs have been shown to have a robust and durable response. However, information regarding the clinical outcomes of TKI treatment, including brain metastasis, remains limited.

 

Signs and Symptoms of ROS1-Positive Lung Cancer

Usually these signs begins only after the cancer has spread, adenocarcinoma and ROS1 variations of adenocarcinoma are usually diagnosed when the cancer has reached an advanced stage.

 

Causes of ROS1-Positive Lung Cancer

Mutations like the ROS1 rearrangement are often acquired, which means that they are not inherited or present at birth.

Following are the risk factors associated with ROS1 positive lung cancer:

  • Age: The median age of patients with ROS1 rearrangements is estimated to be 50 
  • Sex: ROS1 mutations are more common in women patients than male patients. 
  • Smoking history: Lung cancer patents who smoke have a less percentage of ROS1 positivity compared with  patients who don’t smoke, an estimated 67.7% are never-smokers.

 

Diagnosis of ROS1-Positive Lung Cancer

This blood test checks for cancer cells circulating in the blood and can be used to identify genetic mutations in cancer cells.

These diagnostics tests will also help identify the stage of the lung cancer, which is important for determining the best course of treatment for a particular type of NSCLC.

 

Treatment of ROS1-Positive Lung Cancer

If the lung cancer is caught in the early stages-1, 2 or 3A, local treatments may be recommended. These include treatments that work on cancer tumors that are still small and located in one place.

These include the following:

  • Surgery: Options may include removing some lung tissue, a wedge-shaped piece of lung, a lobe of one lung, or an entire lung. 
  • Radiation therapy: High-energy radiation is aimed at tumors to kill cancer cells and eliminate or shrink tumors.

Chemotherapy drugs, which kill cancer cells but also damage healthy cells, are still widely used for lung cancer, but with ROS1 rearrangement, these drugs may not be the first course of treatment. Instead, healthcare providers are now using targeted medications, which offer many advantages.

Targeted Therapy

Currently, two oral medications have U.S. Food and Drug Administration (FDA) approval for patients with metastatic non-small cell lung cancer (NSCLC) who have ROS1-positive lung cancer. These are the following:

  • Rozlytrek (entrectinib)
  • Xalkori (crizotinib)

These targeted therapy drugs are meant to be taken long term. Patients would only stop taking the medications if the cancer starts to spread (metastasize), which indicates the drug is no longer working. Or if the patient cannot tolerate the medication anymore.

Zykadia (ceritinib), a kinase inhibitor indicated for the treatment of ALK-positive (NSCLC), has also been used to treat ROS1-positive lung cancer.

Studies suggest that a component of vitamin E called a-tocopherol may greatly reduce the effectiveness of crizotinib.

 

NSCLC Brain Metastases

Rozlytrek appears to have better brain penetration and has shown success in small trials.

Radiation therapy may also offer some hope for ROS1-positive lung cancer that has spread to the brain. Radiation may be given in a few different ways:

  • Stereotactic radiotherapy: In this approach, which is also referred to as cyberknife or gamma knife, radiation is delivered to localized spots in the brain.
  • Whole-brain radiotherapy: With this method, the entire brain is treated with radiation.

At least 75% of patients undergoing whole-brain radiotherapy report some improvement in symptoms, and it has been shown to improve overall survival from one month with no treatment, to two to seven months with treatment.

Drug Resistance

New drugs are being investigated with clinical trials, and there is hope that new treatments will be available in the future.

Prognosis

Studies of Xalkori (Crizotinib) show that the drug offers a disease-control rate of 90%, and those taking the drugs have no progression of the disease for an average of 19.2 months.

 

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections. 

Samples available are cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.

All our human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data.

This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information.

Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. 

Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved at – 80°C.

Including fresh frozen tissue samplestumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serumplasma and PBMC’s.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

  • Peripheral whole-blood,
  • Amniotic fluid
  • Bronchoalveolar lavage fluid (BAL)
  • Sputum
  • Pleural effusion
  • Cerebrospinal fluid (CSF)
  • Serum (sera)
  • Plasma
  • Peripheral blood mononuclear cells (PBMC’s)
  • Saliva
  • Buffy coat
  • Urine
  • Stool samples
  • Aqueous humor
  • Vitreous humor
  • Kidney stones (renal calculi)
  • Other bodily fluids from most diseases including cancer.

We can also procure most human bio-specimens and can-do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures. 

In addition to the standard processing protocols Bay Biosciences can also provide human plasmaserum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquots from us.

 Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.

 

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