Short Bowel Syndrome (SBS) Specimens

Bay Biosciences provides high-quality, matched fresh frozen sera (serum),  plasma, and peripheral blood mononuclear cells (PBMC) bio-fluids from patients diagnosed with short bowel syndrome.

Moreover, the sera (serum), plasma and PBMC bio-fluids are processed from short bowel syndrome patient’s peripheral whole-blood using customized collection and processing protocols.

In addition, the matched bio-fluids are collected from unique patients with short bowel syndrome and are provided to a valued pharmaceutical customer for research, development and drug discovery.

Short Bowel Syndrome (SBS) Overview

Short Bowel Syndrome (SBS) also known as short gut is a condition in which the body is unable to absorb enough nutrients from the foods you eat, malabsorption disorder is caused by a lack of functional small intestine. The small intestine is where the majority of the nutrients you eat are absorbed into the body during digestion.

Short Bowel Syndrome can occur when:

  • Portions of the small intestine have been surgically removed- Conditions that may require surgical removal of large portions of the small intestine include Crohn’s disease, cancer, traumatic injuries and blood clots in the arteries that provide blood to the intestines.
  • Portions of the small intestine are missing or damaged at birth- Babies may be born with a short small intestine or with a damaged small intestine that must be surgically removed.

Symptoms

The primary signs and symptoms of  Short Bowel Syndrome (SBS) is diarrhea, which can result in dehydration, malnutrition and weight loss. Other symptoms may include bloating, heartburn, feeling of tiredness, fatigue, lactose intolerance, and foul-smelling stool. Complications can include anemia and kidney stones. Most cases are due to the surgical removal of a large portion of the small intestine. This is most often required due to Crohn’s disease in adult patients and necrotising enterocolitis in young children. Other causes include damage to the small intestine from other means and being born with an abnormally short intestine. It usually does not develop until less than 2 m (6.6 ft) of the normally 6.1 m (20 ft) small intestine remains.

Treatment may include a specific diet, medications, or surgery. Short bowel syndrome (SBS) treatment typically involves special diets and nutritional supplements and may require nutrition through a vein (parenteral nutrition) to prevent malnutrition. The diet may include liquids, vitamin and mineral supplements, small frequent meals, and the avoidance of high fat food. Occasionally nutrients need to be given through an intravenous line, known as parental nutrition. Medications to manage Short bowel syndrome (SBS) used may include antibiotics, antacids, loperamide, teduglutide, and growth hormone. Different types of surgery, including an intestinal transplant, may help some people. Outcomes depend on the amount of bowel remaining and whether or not the small bowel remains connected with the large bowel.

Short Bowel Syndrome (SBS) Symptoms

Common signs and symptoms of Short Bowel Syndrome may include:

  • Abdominal pain
  • Diarrhea and Steatorrhea (oily, bulky stool, which can be malodorous)
  • Greasy, foul-smelling stools
  • Fluid Depletion
  • Fatigue
  • Weight loss
  • Malnutrition
  • Swelling (edema) in the lower extremities

Patients with Short Bowel Syndrome (SBS) may have complications caused by malabsorption of vitamins and minerals, such as deficiencies in vitamins A, Bg (Folic acid) and B12, calcium, magnesium, iron and zinc. These may appear as anemia, hyperkeratosis (scaling of the skin), easy bruising, muscle spasms, poor blood clotting and bone Pain.

Short Bowel Syndrome (SBS) Causes

Short bowel syndrome in adults and children is usually caused by surgery.
This surgery may be done for:

  • Crohn’s disease an inflammatory disorder of the digestive tract
  • Volvulus a twisting of the small intestine often caused by intestinal malrotation that quickly cuts off blood supply and leads to tissue death
  • Tumors of the small intestine
  • Injury or trauma to the small intestine
  • Necrotizing enterocolitis (premature newborn)
  • Bypass surgery to treat obesity
  • Surgery to remove diseases or damaged portion of the small intestine

Some children are also born with an abnormally short small intestine, known as congenital short bowel.

Short Bowel Syndrome (SBS) Treatment

Treatment options for short bowel syndrome depends on what parts of the small intestine are affected, whether the colon is intact and other patient preferences.

Short Bowel Syndrome (SBS) treatment may include:

  • Nutritional Therapy: Patients with small bowel syndrome will need to follow a special diet and take nutritional supplements. Some patients may need to get nutrition through a vein (parenteral nutrition) or a feeding tube (enteral nutrition) to prevent malnutrition.
  • Medications: In addition to nutritional support, your doctor may recommend drugs to help manage short bowel syndrome, such as medications to help control stomach acid, reduce diarrhea
    or improve intestinal absorption after surgery.
  • Surgery: Doctors may recommend surgery for children and adults with short bowel syndrome. Types of surgery include procedures to slow the passage of nutrients through the intestine or a procedure to lengthen the intestine (autologous gastrointestinal reconstruction), as well as small bowel transplantation (SBT).

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC) and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, researchers find patient’s data extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

  • Firstly, Peripheral whole-blood
  • Secondly, Amniotic fluid
  • Third, Bronchoalveolar lavage fluid (BAL)
  • Moreover, Sputum
  • Furthermore, Pleural effusion
  • Next, Cerebrospinal fluid (CSF)
  • Also, Serum (sera)
  • Likewise, Plasma
  • In addition, Peripheral blood mononuclear cells (PBMC)
  • For example, Saliva
  • Also, Buffy coat
  • Moreover, Urine
  • Furthermore, stool samples
  • Next, Aqueous humor
  • Likewise, Vitreous humor
  • Lastly, Kidney stones (renal calculi)
  • Finally, Other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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