Bay Biosciences provides high quality, clinical grade bio-samples, cryogenically preserved tissue, sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid specimens from patients diagnosed with Short Bowel Syndrome.
The sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples are processed from patient’s peripheral whole-blood using customized collection and processing protocols. The Short Bowel Syndrome bio-specimens are collected from unique patients diagnosed with Short Bowel Syndrome and are provided to a valued pharmaceutical customer for translational research, genomics, proteomics and biomarker research, drug discovery and development.
Short Bowel Syndrome (SBS) Overview
Short Bowel Syndrome (SBS) also known as short gut is a condition in which the body is unable to absorb enough nutrients from the foods you eat, malabsorption disorder is caused by a lack of functional small intestine. The small intestine is where the majority of the nutrients you eat are absorbed into the body during digestion.
Short Bowel Syndrome can occur when:
- Portions of the small intestine have been surgically removed- Conditions that may require surgical removal of large portions of the small intestine include Crohn’s disease, cancer, traumatic injuries and blood clots in the arteries that provide blood to the intestines.
- Portions of the small intestine are missing or damaged at birth- Babies may be born with a short small intestine or with a damaged small intestine that must be surgically removed.
The primary signs and symptoms of Short Bowel Syndrome (SBS) is diarrhea, which can result in dehydration, malnutrition and weight loss. Other symptoms may include bloating, heartburn, feeling of tiredness, fatigue, lactose intolerance, and foul-smelling stool. Complications can include anemia and kidney stones. Most cases are due to the surgical removal of a large portion of the small intestine. This is most often required due to Crohn’s disease in adult patients and necrotising enterocolitis in young children. Other causes include damage to the small intestine from other means and being born with an abnormally short intestine. It usually does not develop until less than 2 m (6.6 ft) of the normally 6.1 m (20 ft) small intestine remains.
Treatment may include a specific diet, medications, or surgery. Short bowel syndrome (SBS) treatment typically involves special diets and nutritional supplements and may require nutrition through a vein (parenteral nutrition) to prevent malnutrition. The diet may include liquids, vitamin and mineral supplements, small frequent meals, and the avoidance of high fat food. Occasionally nutrients need to be given through an intravenous line, known as parental nutrition. Medications to manage Short bowel syndrome (SBS) used may include antibiotics, antacids, loperamide, teduglutide, and growth hormone. Different types of surgery, including an intestinal transplant, may help some people. Outcomes depend on the amount of bowel remaining and whether or not the small bowel remains connected with the large bowel.
Short Bowel Syndrome (SBS) Symptoms
Common signs and symptoms of Short Bowel Syndrome may include:
- Abdominal pain
- Diarrhea and Steatorrhea (oily, bulky stool, which can be malodorous)
- Greasy, foul-smelling stools
- Fluid Depletion
- Fatigue
- Weight loss
- Malnutrition
- Swelling (edema) in the lower extremities
Patients with Short Bowel Syndrome (SBS) may have complications caused by malabsorption of vitamins and minerals, such as deficiencies in vitamins A, Bg (Folic acid) and B12, calcium, magnesium, iron and zinc. These may appear as anemia, hyperkeratosis (scaling of the skin), easy bruising, muscle spasms, poor blood clotting and bone Pain.
Short Bowel Syndrome (SBS) Causes
Short bowel syndrome in adults and children is usually caused by surgery.
This surgery may be done for:
- Crohn’s disease an inflammatory disorder of the digestive tract
- Volvulus a twisting of the small intestine often caused by intestinal malrotation that quickly cuts off blood supply and leads to tissue death
- Tumors of the small intestine
- Injury or trauma to the small intestine
- Necrotizing enterocolitis (premature newborn)
- Bypass surgery to treat obesity
- Surgery to remove diseases or damaged portion of the small intestine
Some children are also born with an abnormally short small intestine, known as congenital short bowel.
Short Bowel Syndrome (SBS) Treatment
Treatment options for short bowel syndrome depends on what parts of the small intestine are affected, whether the colon is intact and other patient preferences.
Short Bowel Syndrome (SBS) treatment may include:
- Nutritional Therapy: Patients with small bowel syndrome will need to follow a special diet and take nutritional supplements. Some patients may need to get nutrition through a vein (parenteral nutrition) or a feeding tube (enteral nutrition) to prevent malnutrition.
- Medications: In addition to nutritional support, your doctor may recommend drugs to help manage short bowel syndrome, such as medications to help control stomach acid, reduce diarrhea
or improve intestinal absorption after surgery. - Surgery: Doctors may recommend surgery for children and adults with short bowel syndrome. Types of surgery include procedures to slow the passage of nutrients through the intestine or a procedure to lengthen the intestine (autologous gastrointestinal reconstruction), as well as small bowel transplantation (SBT).
Detailed clinical data, CT, MRI scans, MR enterography, stool and blood analysis, elevated biomarker levels, genetic and metabolic information, histopathological findings, annotations associated with the Short Bowel Syndrome (SBS) patient’s specimens is provided to a valued customer for research, development and drug discovery. The Short Bowel Syndrome (SBS) sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples are processed from patients peripheral whole-blood using customized processing protocols provided by the researcher.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer sera (serum), cancer plasma, cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
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Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
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