Bay Biosciences provides high-quality frozen biopsy tissue samples and matched bronchoalveolar lavage (BAL),  sera (serum),  plasma, and peripheral blood mononuclear cells (PBMC) bio-fluids from patients diagnosed with lung cancer.

Moreover, the sera (serum), plasma and PBMC bio-fluids are processed from lung cancer patient’s peripheral whole-blood using customized collection and processing protocols.

In addition, the matched bio-fluids are collected from unique patients with lung cancer and are provided to a valued pharmaceutical customer for research, development and drug discovery.

Types of Lung Cancers

Lung cancers are classified into the following two main types:

  • Non-Small Cell Lung Cancer (NSCLC)
  • Small-Cell Lung Cancer (SCLC)

Non-Small Cell Lung Cancer

Majority of the lung cancer (NSCLC) cases in the United States, around 85% are Non-small Cell Lung cancers (NSCLC). The main subtypes of NSCLC are adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. These subtypes group together as NSCLC, starting from different types of lung cells. Because their treatment and prognoses (outlook) are often similar.

Types of Non-Small Cell Lung Cancer

Following are the sub-types of Non-small cell lung cancer (NSCLC):

Adenoncarcinoma

First, Adenocarcinoma: Lung Adenocarcinomas start in the glandular cells that normally secrete substances such as mucus. Consequently, it tends to develop in smaller airways, such as alveoli.
Furthermore, Lung Adenocarcinoma cancers occur mainly in patients who are current or former smokers. However, it is also the most common type of lung cancer seen in non-smokers. Additionally, it is more common in women than in men. And it is more likely to occur in younger people than other types of lung cancer.
Notably, adenocarcinoma is mostly found in the outer edges of the lung. In fact, it tends to grow more slowly than other lung cancers. Moreover it is usually likely to be detected before it has spread to other organs and parts of the body.
Moreover, patients with a type of adenocarcinoma called adenocarcinoma in situ (previously called bronchioloalveolar carcinoma) tend to have a better outlook than those with other types of lung cancer.

Squamous Cell Carcinoma

Second, Squamous Cell Carcinoma: On the other hand, squamous cell carcinomas is a lung cancer that starts in flat cells that line the inside of the airways in the lungs, which are called squamous cells. In addition, squamous cell carcinomas are usually linked to patients who have a history of smoking. Moreover, squamous cell carcinomas are mostly found in the central part of the lungs, near a main airway (bronchus).

Large Cell Carcinoma

Next, Large Cell (undifferentiated) Carcinoma:  Large cell carcinoma can develop in any part of the lung. It tends to grow and spread quickly, which can make it harder to treat. A subtype of large cell carcinoma, known as large cell neuroendocrine carcinoma, is a fast-growing cancer that is very similar to small cell lung cancer.

Other subtypes: There are few other subtypes of Non-small cell lung cancer (NSCLC), such as adeno-squamous carcinoma and arcomatoid carcinoma, are rare and not as common as adenocarcinomas or squamous cell carcinomas.

Small Cell Lung Cancer (SCLC)

Around 20% of lung cancers diagnosed in the United States are found to be small cell lung cancer (SCLC).

In addition, small-cell lung cancer is a more aggressive form of lung cancer; consequently, it tends to grow quickly and spread faster than non-small SCLC to other organs and parts of the body, as it metastasizes more easily.

Furthermore, about 70% of patients with SCLC will have cancer that has already spread at the time they are diagnosed. Since this cancer grows quickly, it tends to respond well to chemotherapy and radiation therapy.

Unfortunately, for most patients, the SCLC cancer will return at some point; therefore, long-term survival is not common. Moreover, small cell lung cancer may also be referred to as oat cell cancer, oat cell carcinoma, and small cell undifferentiated carcinoma.

Other Types of Lung Cancers

In addition to the above main types of lung cancer, other forms of cancer ( tumors) can also develop in the lungs. Furthermore, following are some of the additional types of tumors that can occur in the lungs:

Firstly, lung carcinoid tumors: Carcinoid tumors of the lung are rare and account for fewer than 5% of lung tumors. Specifically, we call cancers that form from neuroendocrine cells in the lungs lung carcinoid tumors. Moreover, most of these carcinoid tumors grow slowly.

Secondly, other lung tumors: Other types of lung cancer such as adenoid cystic carcinomas, lymphomas, and sarcomas, as well as benign lung tumors such as hamartomas are rare. Consequently, doctors treat these differently from the more common lung cancers and do not discuss them here.

Lastly, cancers that spread to the lungs: Cancers that start in other organs (such as the breast, liver, pancreas, kidney, or skin) can sometimes spread (metastasize) to the lungs; however, these are not lung cancers. For instance, cancer that starts in the breast and spreads to the lungs is still breast cancer, not lung cancer. Therefore, treatment for metastatic cancer to the lungs is based on where it started or the primary cancer site.

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC) and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, researchers find patient’s data extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

  • Firstly, Peripheral whole-blood
  • Secondly, Amniotic fluid
  • Third, Bronchoalveolar lavage fluid (BAL)
  • Moreover, Sputum
  • Furthermore, Pleural effusion
  • Next, Cerebrospinal fluid (CSF)
  • Also, Serum (sera)
  • Likewise, Plasma
  • In addition, Peripheral blood mononuclear cells (PBMC)
  • For example, Saliva
  • Also, Buffy coat
  • Moreover, Urine
  • Furthermore, stool samples
  • Next, Aqueous humor
  • Likewise, Vitreous humor
  • Lastly, Kidney stones (renal calculi)
  • Finally, Other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

  • 日本のお客様は、ベイバイオサイエンスジャパンBay Biosciences Japanまたはhttp://baybiosciences-jp.com/contact/までご連絡ください。