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Uveitis Aqueous Humor Samples

by | Aug 10, 2024 | News Releases | 0 comments

Bay Biosciences provides high-quality, frozen aqueous humor samples with matched sera (serum), EDTA plasma and peripheral blood mononuclear cells (PBMC’s), bio-fluids from uveitis patients for research.

The PBMCs, sera (serum) and plasma bio-fluid specimens are processed from uveitis patients peripheral whole-blood using customized collection and processing protocols.

Uveitis Overview

Uveitis is inflammation of the middle layer of the eye, or the uvea, and the surrounding tissue. It can cause pain, eye redness, and cloudy vision.

The term “uveitis” refers to a range of conditions rather than a single symptom. An injury to the eye, infection, inflammation, and some underlying diseases may cause it.

Uveitis can lead to swelling and damage in the tissue of the eye. Untreated, it may lead to vision loss and other issues. It can affect one or both eyes.

What is Uveitis?

Inflammation of uvea is known as uveitis. It is also known as the uveal layer, uveal coat, uveal tract, or vascular tunic, is the middle layer of tissue found in the wall of the eye. This layer within the eye helps with several functions, including absorption of light and focusing.

The uvea consists of several parts. These include the:

  • Choroid, which helps the lens focus
  • Iris, which is the colored part of the eye that surrounds the pupil
  • Ciliary body, which contains a ring of muscle that sits behind the iris

The different types of uveitis affect different parts of the uvea, as described below.

Types of Uveitis

There are four different types of uveitis based on where they occur on the uvea.

They include the following:

  • Anterior uveitis: This is the most common form of uveitis. Also known as iritis, it affects the front part of the eye. Doctors think it results from inflammation of the iris. Iridocyclitis is similar, but it includes inflammation of the ciliary body.
  • Intermediate uveitis: Intermediate uveitis can be vitritis or pars planitis. Vitritis is an inflammation of the jelly-like part of the eye, the vitreous cavity. When there is no underlying cause for the intermediate uveitis, it is known as pars planitis. Pars planitis is a subtype of intermediate uveitis that has no underlying systemic disease or infection.
  • Posterior uveitis: Posterior uveitis is an inflammation of the retina and choroid. Posterior refers to the back of the eye.
  • Panuveitis: Panuveitis is inflammation in all layers of the uvea. This type of uveitis can affect other areas of the eye, including the lens, retina, optic nerve, and vitreous. It can cause reduced vision and blindness.

Uveitis types can be either acute or chronic. “Acute” means short-term, while “chronic” means long-term.

Symptoms of Uveitis

The signs and symptoms of uveitis can vary. Often, they occur suddenly, but they can come on gradually. Possible symptoms include:

  • Eye pain and redness
  • Floaters, which are spots in the eye that look like tiny rods or chains of transparent bubbles floating around in the field of vision
  • General vision problems, including blurred or cloudy vision
  • Headaches
  • Photophobia, an abnormal sensitivity to light

Without treatment, uveitis can lead to vision loss.

Causes of Uveitis

Uveitis can occur in anyone. The inflammation may occur only in the eye, or have links to conditions that affect other parts of the body, too.

Infections that may cause or increase the risk of uveitis include:

Autoimmune and Inflammatory Diseases

Autoimmune and inflammatory disorders may also cause uveitis. These include the following:

Injury may be due to trauma, recent surgery, or exposure to chemicals. Injury to the eye is another possible cause of uveitis.

Risk Factors of Uveitis

Several factors can increase a person’s risk of developing uveitis. Some common risk factors are:

  • Low vitamin-D levels
  • Pregnancy
  • Smoking
  • Living with an autoimmune disease
  • Low vitamin-D levels
  • Use of certain medications

In addition, females have a higher chance of developing uveitis than males.

Diagnosis of Uveitis

An eye doctor will be able to see uveitis when performing an eye exam.

During an eye exam, the doctor will look at the eye with a special slit lamp. The key feature of uveitis is seeing white blood cells either in the anterior chamber or vitreous.

Other findings include bumps on the cornea, called keratic precipitates. If there is inflammation in the iris, patients may feel some pain when the pupil contracts, which is when light hits it.

Due to the number of potential underlying conditions that may cause uveitis, the doctor may refer a person to a uveitis specialist or rheumatologist for a complete check-up and diagnosis of an underlying condition.

Treatment of Uveitis

A person with uveitis who receives prompt and appropriate treatment will usually recover. Without treatment, the risk of cataracts, glaucoma, band keratopathy, retinal edema, and permanent vision loss increases.

According to the American Academy of Ophthalmology, the most common treatment for uveitis involves the use of corticosteroid drops to help reduce inflammation. In addition, a person may use eye drops to help open the pupils, which reduces swelling and pain.

Medications

An ophthalmologist may also prescribe one of the following:

  • A surgical implant that provides small doses of steroids over time
  • Injected steroids given either around or in the eye
  • Oral steroids in the form of pills

A doctor may also recommend immunomodulator therapy or biologics to help reduce the immune system response. If an ophthalmologist or optometrist suspects an underlying autoimmune disorder, they will likely recommend that a person contact a rheumatologist for specialized care.

Which treatment a doctor recommends can vary based on the type of uveitis.

Treating Anterior Uveitis

Some common treatments for anterior uveitis include the following:

  • Drops to reduce pressure on eyes
  • Eye drops to widen the pupil
  • Topical corticosteroids

Treating intermediate and posterior uveitis

A doctor may use additional methods to treat intermediate, posterior, and anterior uveitis, including:

  • Antivirals, antibiotics, or other medications 
  • Biologic agents
  • Corticosteroids in the form of injections, implants, or oral medication 
  • Immunosuppressants
  • Nonsteroidal anti-inflammatory drugs to treat pain and swelling
  • Corticotropin

The treatment they suggest will depend on the underlying cause.

Complications of Uveitis

Prompt treatment and close monitoring can help reduce the risk of complications.

If they do occur, they may include:

  • Glaucoma
  • Cataracts
  • Macular edema
  • Retinal detachment
  • Scar tissue
  • Vision loss

Outlook for Uveitis

With early diagnosis and treatment, the outlook for uveitis is often positive. While people can develop complications, there are treatments that can significantly reduce the risk of permanent vision loss.

The time it takes to recover from uveitis depends on the underlying cause, and whether it is acute or chronic.

 

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