Vitreous Humor Samples for Research

Bay Biosciences provides fresh frozen (-80°) high quality, clinical grade vitreous humor bio-fluid samples from healthy donors for research.

Vitreous Humor Overview

The vitreous humor is a gel-like liquid between the lens and the retina. Moreover it is an essential part of the eye. In addition, it helps the eye keep its shape and absorbs shock. It also maintains correct oxygen levels within the eye.

Additionally, also known as the vitreous body, this gel-like liquid comprises most of the eye, helping it to keep shape.

What is Vitreous Humor?

The vitreous humor is a transparent, gel-like substance present in the eye. In. fact, this substance makes up an estimated 80% of the eye’s total volume.

Furthermore, the vitreous humor has several important functions. Specifically, it maintains the shape of the eye, assisting vision, and absorb shock.

Anatomy of Vitreous Humor

As a 2022 research review explains, the eye is a complex organ.

First, the outermost part of the front of the eye is the cornea, which partly acts as a protective layer.

Next, just behind the cornea is the iris. This is the colored section at the front of the eye. Moreover, it can control the size of the pupil — the hole at the center of the iris — to determine how much light reaches the lens.

Then, the lens is just behind the iris, and its job is to focus incoming light toward the retina.

Further, the retina is at the very back of the eye. Its job is to register different properties of light before sending that information to the brain via the optic nerve.

Finally, between the lens and the retina is the vitreous humor, keeping everything in place.

Function of Vitreous Humor

Research from 2020 has shown that the vitreous has several important roles to play within the eye.

Maintaining the shape of the eye

Furthermore, given its sizable share of the eye’s total volume, the vitreous humor is essential for maintaining the shape of the eye. In addition, it holds the lens and retina in place.

Vision clarity

Because it is transparent, the vitreous humor allows light to travel through the lens and onto the retina.

Shock absorption

The vitreous humor is a soft, viscous liquid. Consequently, and as a result it allows the eye to absorb some shocks, and as a result, this helps prevent certain injuries.

Maintaining oxygen gradient

For optimal eye function and to reduce oxidative stress, the eye must distribute oxygen in a specific way.

Specifically, there should be a higher oxygen concentration near the retina and a lower oxygen concentration near the lens. Furthermore, the vitreous humor makes sure that the eye maintains a proper oxygen balance.

Vitreous Humor vs. Aqueous Humor

The eye contains two main liquid-like substances. One is the vitreous humor: however, the other is the aqueous humor.

Scientists have noted several important differences between these substances. For instance, aqueous humor is more water-like than vitreous humor, which has a gel-like consistency.

Moreover, the aqueous humor is also present between the lens and the cornea.

Injury

A person may injure the vitreous humor in several ways.

For instance, a 2022 review explains that the vitreous humor can sustain damage from blunt trauma. Specifically this involves a severe shock to the eye, such as from an object hitting the eye.

Moreover, the vitreous humor can also sustain damage from penetrating trauma, which occurs when sharp objects poke into and damage the eye.

Furthermore, eye injuries have potential adverse effects, such as posterior vitreous detachment, retinal tears, and retinal detachments. Notably, this occurs when the retina detaches from the vitreous cortex. In fact, the vitreous cortex is a layer that separates the vitreous humor from the rest of the eye.

Other Concerns

According to a 2022 review, vitreous floaters, in fact, are a common sign of posterior vitreous detachment (PVD). Additionally, PVD is common in older individuals.

Furthermore, they can also develop for other reasons.

Moreover, vitreous floaters are more commonly known as just floaters. Specifically, they are clumps of collagen fibers. Although they can be a little distracting, small amounts of floaters are not usually harmful.

Finally, if there is no serious underlying cause, vitreous floaters should resolve on their own.

Complications

Problems with the vitreous humor can have serious complications.

Furthermore, a posterior vitreous detachment can cause retinal damage, leading to loss of sight.

Moreover, a PVD can also lead to vision loss in other ways. For instance, this condition can cause vitreous hemorrhage, when blood enters the vitreous humor.

In addition, living with large numbers of vitreous floaters can be difficult. Consequently,  research has shown that vitreous floaters can cause some people to develop suicidal ideation. This, in turn, can happen with serious cases of PVD.

Surgery

In some cases, therefore, doctors must operate upon the vitreous humor. This need can arise when the vitreous humor becomes too cloudy or is otherwise unable to fulfill its function.

One such operation, specifically, is a vitrectomy. As 2022 research explains, a vitrectomy removes the vitreous humor. Consequently doctors aim to replace the vitreous humor with a synthetic substitute with similar properties.

Although this operation can greatly improve an individual’s vision, it is delicate and highly complex. Furthermore, complications following a vitrectomy are common.

Seeking Medical Help

If someone experiences noticeable changes in their vision, they should seek their doctor’s advice.

In particular, these changes might include a marked increase in vitreous humor floaters. Accordingly, they might also include the experience of bright flashes.

Furthermore, a 2022 review lists these as symptoms of posterior vitreous detachment. Combined, they require swift medical attention.

Moreover, anyone with a vitreous hemorrhage should seek urgent medical attention. Research has shown that vitreous hemorrhage can indicate several serious conditions.

Alongside posterior vitreous detachment, these include intracranial hemorrhage and hemophilia.

Frequently Asked Questions

Following are some answers some frequently asked questions about vitreous humor.

Can vitreous humor be replaced?

Yes, doctors can replace it with artificial substances.

How do I keep my vitreous gel healthy?

2019 study proposed that taking micronutrients such as vitamin C, hesperidin, zinc, leucocyanidin, lysine, and verbascosides may help slow or prevent the age-related degeneration of the vitreous humor.

However, researchers have not yet observed how this method works in human studies.

Furthermore, they suggest it may work indirectly by preventing oxidative stress, which may be a factor in vitreous humor-related concerns.

Therefore, a person should always consult a doctor before changing their diet or taking supplements.

In addition, people can also maintain a healthy vitreous gel by avoiding damage to the vitreous.

Outlook

The vitreous humor makes up a large part of the eye and plays several essential functions.

Moreover, several conditions can affect this liquid, potentially causing serious vision loss. However, treatment is often available.

In addition, doctors can sometimes replace vitreous humor with artificial substances to help with vision loss and other vision issues.

 

Detailed clinical data and pathology annotations including patient’s corresponding diagnostic test values associated with the biospecimens are provided to a valued pharmaceutical customer for diagnostics, research, development and drug discovery.

Furthermore, Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples. We provide biospecimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.

In addition, Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.

All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data.

Moreover, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information.

Furthermore, patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness. 

We bank wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samplestumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serumplasma and PBMC’s.

Bay Biosciences specializes in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including the following

  • Aqueous humor
  • Amniotic fluid
  • Bronchoalveolar lavage fluid (BAL)
  • Buffy coat
  • Cerebrospinal fluid (CSF)
  • Kidney stones
  • Sputum
  • Nephrolithiasis
  • Pleural effusion 
  • Peripheral whole-blood
  • Plasma
  • Renal calculi
  • Serum (sera)
  • Peripheral blood mononuclear cells (PBMC’s)
  •  Saliva
  •  Stool samples,
  • Vitreous humor
  • Urolithiasis and other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures. 

In addition to the standard processing protocols Bay Biosciences can also provide human plasmaserum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.

 

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