Bay Biosciences provides Diffuse Large B-Cell Lymphoma (DLBCL) FFPE tissue blocks with matching serum (sera), plasma samples with detailed clinical annotations to a pharmaceutical customer for research.

Diffuse Large B-Cell Lymphoma (DLBCL) Overview

Diffuse large B-cell lymphoma (DLBCL) originates in white blood cells called lymphocytes. Specifically, it usually grows in lymph nodes, which are the pea-sized glands. These are located in the neck, groin, armpits, and elsewhere in the body, and are part of the immune system.

In addition, lymphocytes, which are part of the immune system, travel around the body in the lymphatic system, helping to fight infections. Moreover, the two types of lymphocytes are T lymphocytes or T-cells and B lymphocytes or B cells. Furthermore, diffuse large B-cell lymphoma (DLBCL) can also develop in other areas of your body.

Notably, diffuse large B-cell lymphoma (DLBCL) represents the most most common type of non-Hodgkin’s lymphoma (NHL) in the United States and worldwide. In fact, accounting for about  22 percent of newly diagnosed cases of B-cell NHL in the United States. Consequently, doctors diagnose more than 18,000 patients with diffuse large B-cell lymphoma (DLBCL) each year.

In particular, diffuse large B-cell lymphoma (DLBCL) aggressively affects B-lymphocytes, which are one type of white blood cell. In fact, B-cells, which are lymphocytes, make antibodies to fight infections and are an important part of the lymphatic system. Interestingly, diffuse large B-cell lymphoma (DLBCL) can occur in childhood, and the occurrence of DLBCL generally increases with age, with most doctors diagnosing patients over the age of 60.

Moreover DLBCL can develop in the lymph nodes or in “extranodal sites” which are areas outside the lymph nodes, In particular, the gastrointestinal tract, testes, thyroid, skin, breast, bone, brain, or essentially any organ of the body. Furthermore, it may be localized, in one spot or generalized spread throughout the body.

Types of Diffuse Large B-Cell Lymphoma (DLBCL)

Most patients with diffuse large B-cell lymphoma (DLBCL) do not have a specific type. In fact, doctors refer to this as Diffuse large B-cell lymphoma (DLBCL) not otherwise specified or ‘DLBCL NOS’. Moreover, around  25% to 30% of doctors diagnose non-Hodgkin’s lymphoma (NHL) cases in adults in developed countries.

Typically, doctors analyze a diffuse large B-cell lymphoma (DLBCL) patient’s biopsy tissue sample to find out the exact type of B cell from which the lymphoma developed. Consequently, researchers categorize cases of DLBCL-NOS into molecular subgroups based on their genetic and immune-phenotypic characteristics.

Following this, here are the main cell types:

  • Germinal Center B Cells (GCB)
  • Activated B Cells (ABC)

Currently, most patients with diffuse large B-cell lymphoma (DLBCL) not otherwise specified (NOS) receive the same treatment. However, researchers are working to determine if different treatments may be more effective against specific types of diffuse large B-cell lymphoma (DLBCL) that developed from different cells.

Ultimately, this research may help doctors choose the more effective and appropriate treatment for each type of diffuse large B-cell lymphoma (DLBCL).

In addition, some patients have a rare subtype of diffuse large B-cell lymphoma (DLBCL) or other large B-cell lymphoma. Furthermore, pathologists usually detect these subtypes by examining the biopsy tissue sample under a microscope or using specialist laboratory tests. These sub-types of DLBCL can cause different symptoms from the most common type of DLBCL NOS.

Diffuse Large B-Cell (DLBCL) Sub-Types

Researchers categorize diffuse large B-cell lymphoma as a heterogeneous group of lymphomas. Consequently, this categorization reveals that the different subtypes exhibit different genetic features, behaviors, and responses to treatment.

Moreover, the subtypes depend on the cancer’s location in the body, the genes and proteins involved, and whether the cancer involves a virus such as Epstein-Barr virus (EBV). In addition, the subtypes of diffuse large B-cell lymphoma include:

  • First, researchers classify diffuse large B-cell lymphoma, not otherwise specified.
  • Furthermore, researchers identify T-cell-histiocyte-rich large B-cell lymphoma.
  • Additionally, researchers recognize, anaplastic lymphoma kinase (ALK) positive large B-cell lymphoma.
  • Next, researchers classify large B-cell lymphoma with IRF4 rearrangement.
  • Similarly, researchers identify EBV-positive diffuse large B-cell lymphoma.
  • Furthermore, researchers classify diffuse large B-cell lymphoma associated with chronic inflammation.
  • Moreover,, researchers classify fibrin-associated large B-cell lymphoma.
  • Likewise, researchers identify fluid overload-associated large B-cell lymphoma.
  • In addition, researchers classify primary large B-cell lymphoma of immune-privileged sites.
  • Finally, researchers recognize primary cutaneous diffuse large B-cell lymphoma, leg type.
  • Additionally, researchers classify primary diffuse large B-cell lymphoma of the central nervous system.
  • Lastly, researchers identify intravascular large B-cell lymphoma.

Symptoms of Diffuse Large B-Cell Lymphoma (DLBCL)

Diffuse large B-cell lymphoma symptoms vary depending on where the lymphoma develops. Firstly, the most common signs and symptoms include:

Diffuse large B-cell lymphoma symptoms can vary depending on where the lymphoma develops. The most common signs and symptoms include:

  • Specifically, a fast-growing mass in the neck or belly.
  • Additionally, painless swelling in the neck, armpit or groin.
  • Moreover, fever arises.
  • Further, fatigue sets in.
  • In addition, drenching night sweats.
  • Ultimately, patients lose weight without trying.

If DLBCL affects the gastrointestinal system, symptoms may include:

  • For instance, pain or fullness in the belly.
  • Similarly, nausea happens.
  • Consequently, vomiting occurs.
  • As a result, loss of appetite develops.
  • Therefore, patients Lose weight without trying.

Meanwhile, DLBCL of the nervous system can affect the brain, cranial nerves, spinal cord and the protective coatings on the brain and spinal cord, called the meninges. Moreover, It also may affect the eyes. When the nervous system is involved, symptoms may include:

  • For example, headaches occur.
  • In addition, confusion arises.
  • Furthermore vision changes changes happen.
  • As a result, patients experience troubles with thinking and speaking.
  • Consequently, changes in behavior.
  • Finally, seizures occur.

DLBCL can affect other parts of the body and cause symptoms such as:

  • In particular, the chest, cough, shortness of breath, trouble swallowing (dysphagia) and pain when breathing.
  • On the other hand, In the bones, patients feel bone pain with risk of fracture.
  • In contrast, in the liver, belly pain.
  • Additionally, in the kidneys, patients notice blood in the urine, increased urination, frequently waking up to urinate, and belly or lower back pain.
  • Lastly, in the skin, skin changes and a rash on the legs.

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

Customized Collections

Moreover, we can also procure most human bio-specimens. Furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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