Bay Biosciences provides high quality, clinical grade fresh frozen serum, plasma and bronchial lavage fluid (BAL) samples from patients diagnosed with mesothelioma. Detailed patients information and clinical data associated with the mesothelioma lung cancer serum, plasma and bronchial lavage  fluid (BAL) samples are provided to a pharmaceutical customer for research, development and discovery.

 

 

Mesothelioma Overview

Mesothelioma is a type of cancer that develops from the thin layer of tissue that covers the majority of the internal organs, known as the mesothelium. Furthermore, mesothelioma is an aggressive and deadly form of cancer. Although mesothelioma treatments are available, for many patients with mesothelioma, a cure is not possible. In addition, mesothelioma most often affects the tissue that surrounds the lungs (pleura); consequently, this type is called pleural mesothelioma. Moreover, other, rarer types of mesothelioma affect tissue in the abdomen (peritoneal mesothelioma), around the heart, and around the testicles.

Notably, the most common area affected is the lining of the lungs and chest wall. Conversely, less commonly, the lining of the abdomen may be affected, and rarely, the sac surrounding the heart or the sac surrounding the testis may also be affected. In terms of signs and symptoms, mesothelioma may include shortness of breath due to fluid around the lungs, a swollen abdomen, chest wall pain, cough, fatigue, and weight loss. Ultimately, these symptoms typically come on slowly.

Mesothelioma Symptoms

Signs and symptoms of mesothelioma vary depending on where the cancer occurs.

Pleural Mesothelioma affects the tissue that surrounds the lungs and causes signs and symptoms that may include:

On the other hand, Peritoneal mesothelioma occurs in tissue in the abdomen and causes signs and symptoms that may include:

Furthermore Other Forms of Mesothelioma

In fact, signs and symptoms of other types of mesothelioma are unclear, since these forms of the disease are very rare.

For example, pericardial mesothelioma, which affects tissue that surrounds the heart, can cause signs and symptoms such as breathing difficulty, shortness of breath, and chest pains.

Similarly, mesothelioma of tunica vaginalis, which affects tissue surrounding the testicles, may be first detected as swelling or a mass on a testicle.

Causes of Mesothelioma

In general, cancer begins when a series of changes (mutations) happens in a cell’s DNA. Specifically, the DNA contains the instructions that tell a cell what to do. Consequently, the mutations tell the cell to grow and multiply out of control. As a result, the abnormal cells accumulate and form a tumor. However, it is not clear what causes the initial genetic mutations that lead to Mesothelioma.

Although researchers have identified factors that may increase the risk. However, It’s likely that cancer form because of an interaction between many factors, such as inherited conditions, environment, health conditions and lifestyle choices.

Mesothelioma Risk Factors

Asbestos exposure: The primary risk factor for Mesothelioma

Most mesotheliomas are thought to be related to asbestos exposure. Specifically, asbestos is a mineral that’s found naturally in the environment. Furthermore, asbestos fibers are strong and resistant to heat, making them useful in a wide variety of applications, such as in insulation, brakes, shingles, flooring, and many other products.

When asbestos is broken up, for example, during the mining process or when removing asbestos insulation, dust may be created. If, therefore, the dust is inhaled or swallowed, the microscopic asbestos fibers will settle in the lungs or in the stomach, where they can cause irritation that may lead to mesothelioma. However, exactly how this happens is not understood. Moreover, it can take 20 to 60 years or more for mesothelioma to develop after asbestos exposure.

Nevertheless, most people with asbestos exposure never develop mesothelioma. This indicates that, in fact, other factors may be involved in determining whether someone gets mesothelioma. For instance, you could inherit a predisposition to cancer, or alternatively, some other condition could increase your risk.

Factors that may increase the risk of mesothelioma include:

  • Personal history of asbestos exposure: If a person has been directly exposed to asbestos fibers at work or at home, the risk of mesothelioma is greatly increased.
  • Furthermore, living with someone who works with asbestos can also pose a risk. People who are exposed to asbestos may carry the fibers home on their skin and clothing. Consequently, exposure to these stray fibers over many years can put others in the home at risk of mesothelioma. However, people who work with high levels of asbestos can reduce the risk of bringing home asbestos fibers by showering and changing clothes before leaving work.
  • Additionally, a family history of mesothelioma is another important factor to consider. If a parent, sibling, or child has mesothelioma, you may have an increased risk of this disease
  • Similarly, radiation therapy to the chest is also a potential risk factor. If you had radiation therapy for cancer in your chest, you might have an increased risk of mesothelioma.

Complications of Mesothelioma 

As Pleural Mesothelioma spreads in the chest, it puts pressure on the structures in that area. This can cause complications, such as:

  • Difficulty Breathing
  • Chest pain
  • Difficulty Swallowing
  • Pain caused by pressure on the nerves and spinal cord
  • Accumulation of fluid (Pleural Effusion) in the chest, which can compress the lung nearby and make breathing difficult.

Mesothelioma Prevention

Reducing your exposure to asbestos may lower your risk of Mesothelioma. Find out whether you work with asbestos. Most patients with Mesothelioma were exposed to the asbestos fibers at work. Workers who may encounter asbestos fibers include:

  • Asbestos Miners
  • Electricians
  • Plumbers
  • Pipefitters
  • Insulators
  • Shipyard Workers
  • Demolition Workers
  • Brake Mechanics
  • Selected Military Personnel
  • Home Remodelers

Be safe around Asbestos in your Home and Workplace

Follow all safety precautions in your workplace, such as wearing protective equipment. Older homes and buildings may contain asbestos. In many cases, it’s more dangerous to remove the asbestos than it is to leave it intact. Breaking up asbestos may cause fibers to become airborne, where they can be inhaled. 

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

Customized Collections

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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