Clear cell Renal Cell Carcinoma (ccRCC) Samples

Bay Biosciences provides high-quality, FFPE tissue blocks with matched fresh frozen sera (serum),  plasma, and peripheral blood mononuclear cells (PBMC) bio-fluids from patients diagnosed with Clear cell Renal Cell Carcinoma (ccRCC).

Moreover, the sera (serum), plasma and PBMC bio fluids samples are processed from clear cell renal cell carcinoma (ccRCC) patient’s peripheral whole-blood using customized collection and processing protocols.

In addition, the matched bio-fluids are collected from unique patients with CCRCC and are provided to a valued pharmaceutical customer for research, development and drug discovery.

Clear cell Renal Cell Carcinoma (ccRCC) Overview

Clear cell renal cell carcinoma (ccRCC) occurs when cancer grows in the kidneys. Symptoms can include blood in urine, a lump in the side, pain, fever and more.

The exact cause of ccRCC is unclear. However, in some cases, it may run in families. Additionally, certain factors, such as obesity or smoking cigarettes, may also increase a person’s risk.

Prevalence

In fact, ccRCC is the most common form of kidney cancer. It accounts for about 80% of all cases in adults. Additionally, it accounts for about 2–6% of all kidney cancer cases in children and young adults.

Clear cell Renal Cell Carcinoma Samples

Symptoms of ccRCC

In some cases, ccRCC may not cause symptoms. Consequently, when no symptoms occur, a doctor may only discover the cancer during an unrelated examination.

When they do occur, symptoms can include:

Furthermore, other types of cancer and noncancerous, or benign, conditions can also cause these symptoms. Therefore, a person can consider talking with a doctor if they experience one or more of these symptoms to determine the exact underlying cause.

Causes of ccRCC

Experts do not know the exact cause of ccRCC.

However, experts do know that certain factors can raise the risk of ccRCC, such as:

  • Hypertension, which is high blood pressure 
  • Obseity
  • smoking cigarettes

Notably, these are considered modifiable risk factors. Conversely, other risk factors of ccRCC that a person cannot change include:

having had a kidney transplant.

  • Firstly, a history of previous renal cell carcinoma
  • Secondly, having had a kidney transplant
  • Thirdly, chronic kidney disease (CKD)
  • In addition, diabetes
  • Next, hemodialysis, or using a machine to filter blood
  • Likewise, acquired cystic kidney disease

It is best for a person to contact a doctor if they have concerns about the risk factors of ccRCC.

Diagnosis of ccRCC

Doctors may diagnose ccRCC during another examination or when a person has symptoms. Initially, diagnosis often starts with a physical examination and a review of the person’s medical history.

If a doctor suspects a person may have an issue with their kidneys, they may order imaging tests such as:

For example, X-ray, MRI, and CT scan. Furthermore, these tests can be useful in identifying a tumor, determining its size, and whether the cancer has spread to other areas of the body.

Subsequently, when a doctor discovers a tumor or growth in the kidney, they need to take a biopsy to check whether it is ccRCC. To do this, a qualified healthcare professional typically inserts a needle into the tumor and extracts a few cells.

Afterward, doctors can then examine these cells under a microscope to determine whether they are cancerous. Notably, ccRCC gets its name from how the cells appear clear under a microscope.

In addition, a doctor may also order blood tests to check blood counts and for the presence of certain chemicals in the blood that could indicate an issue such as cancer is present.

Treatment of ccRCC

Treatment for ccRCC can vary based on several factors, such as the tumor size, whether it has spread to other areas of the body, and a person’s overall health when they receive a diagnosis. **For instance**, some treatment approaches a doctor may recommend include:
  • Firstly, Surgery: A surgeon can remove the tumor from the kidney. However, surgery may not be a good option in cases where the cancer has spread.
  • Additionally, Targeted therapy: Some medications specifically target changes in cancer cells that allow them to divide, grow, and spread. For example, examples of these medications include:
    • Axitinib
    • Cabozantinib
    • pazopanib
    • Sorafenib
    • Sunitinib
  • Moreover, Radiation therapy: Radiation can kill cancer cells.
  • Furthermore, Immunotherapy: This treatment teaches the immune system to kill cancer cells.
  • In addition, Thermal ablation: Heat can destroy cancer cells.
  • Likewise, Cryosurgery: Liquid nitrogen can freeze and destroy cancer cells.
Ultimately, a person’s doctor can recommend treatments based on their individual circumstances and answer any questions the person may have.

Is ccRCC hereditary?

According to the National Cancer Institute, ccRCC may be hereditary. Specifically, the majority of cases that run in families occur in people living with a genetic condition known as Von Hippel-Lindau syndrome; however, other genetic conditions and mutations can cause it to occur too. Moreover, Von Hippel-Lindau syndrome is a rare genetic condition that causes tumors and cysts to grow in different areas of the body, including the brain and kidneys. Consequently, people who develop ccRCC have changes to their VHL gene.

Prevention of ccRCC

While it may not be possible to fully prevent ccRCC, a person can take steps to reduce their risk. In particular, steps a person can take to reduce risk factors include factors: For example, avoiding smoking cigarettes, maintaining a moderate weight, managing blood pressure, avoiding the pain relief medication acetaminophen, and avoiding exposure to certain chemicals, such as trichloroethylene. Furthermore, a doctor can provide more advice on reducing a person’s risk of ccRCC.

FAQ’s

Now, let’s address some common inquiries.

Here are some frequently asked questions about ccRCC.

What is the survival rate of clear cell renal cell carcinoma? Doctors typically use a 5-year survival rate for ccRCC.

Specifically, according to the National Cancer Institute, the 5-year survival rate is 50-69% for localized cancer and 10% for cancer that has spread to distant areas of the body.

Moreover, it is important to remember that a person’s outlook depends on their individual circumstances. Consequently, a person’s doctor can provide more accurate information about their condition.

How bad is clear cell renal cell carcinoma?

CcRCC is a potentially fatal form of cancer. Nevertheless, a person’s overall survival and outlook can vary based on several factors, such as:

  • For instance, age
  • The cancer’s response to treatment
  • Size of the tumor,
  • Location of the tumor, and
  • Whether cancer has spread to other areas of the body.

Moreover, early detection is generally best and can improve a person’s outlook. Furthermore, doctors may be able to find the cancer early, but in some cases, they will not find it until it advances. Consequently, this is because a person may not have any noticeable symptoms to begin with.

Experts generally only recommend early detection tests for people at higher risk, such as those living with certain genetic conditions.

How fast does clear cell renal cancer spread?

Renal tumors have a generally slow growth rate. In some cases, a doctor may recommend watchful waiting before surgically removing a tumor.

Outlook for ccRCC

Furthermore, a person’s outlook can vary based on several factors. These can include:

  • First, whether the cancer has spread
  • Next, the location and size of the tumor
  • Finally, how successful surgical removal was

Importantly, the 5-year survival rate, or the average number of people still alive 5 years following diagnosis, is 50–69% for localized tumors that have not spread, according to the National Cancer Institute.

On the other hand, the survival rate is about 10% in cases where the cancer spreads to other areas of the body.

Biospecimens

biospecimen

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC) and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, researchers find patient’s data extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

  • Firstly, Peripheral whole-blood
  • Secondly, Amniotic fluid
  • Third, Bronchoalveolar lavage fluid (BAL)
  • Moreover, Sputum
  • Furthermore, Pleural effusion
  • Next, Cerebrospinal fluid (CSF)
  • Also, Serum (sera)
  • Likewise, Plasma
  • In addition, Peripheral blood mononuclear cells (PBMC)
  • For example, Saliva
  • Also, Buffy coat
  • Moreover, Urine
  • Furthermore, stool samples
  • Next, Aqueous humor
  • Likewise, Vitreous humor
  • Lastly, Kidney stones (renal calculi)
  • Finally, Other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

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