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Bay Biosciences provides high quality, clinical grade, fresh frozen sera (serum), plasma and peripheral blood mononuclear cells (PBMCbiofluid samples from patients diagnosed with Acute Respiratory Distress Syndrome (ARDS).

The sera (serum), plasma and PBMC biofluid specimens are processed from acute respiratory distress syndrome (ARDS) patient’s peripheral whole-blood using customized collection and processing protocols. The acute respiratory distress syndrome (ARDS) matched biofluid samples are collected from unique patients diagnosed with acute respiratory distress syndrome (ARDS) and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.

Detailed clinical data, patient’s history, symptoms, complete blood count (CBC), serology, MRI findings, histopathology information, elevated biomarker levels, genetic and metabolic information associated with acute respiratory distress syndrome (ARDS) specimens is provided to a valued customer for research, development and drug discovery.

The acute respiratory distress syndrome (ARDS) cancer sera (serum), plasma and peripheral blood mononuclear cells (PBMCbiofluids are processed from patients peripheral whole-blood using customized collection and processing protocols.

Acute Respiratory Distress Syndrome (ARDS) Overview

Acute respiratory distress syndrome (ARDS) is a serious life-threatening lung injury where fluid fills up the tiny, elastic air sacs (alveoliin the lungs and this fluid leaks into the lungs. Too much fluid in the lungs can lower the amount of oxygen or increase the amount of carbon dioxide in the bloodstream. This deprives your organs of the oxygen they need to function. Breathing becomes difficult and oxygen cannot get into the body. ARDS can prevent the organs from getting the oxygen they need to function, and it can eventually cause organ failure. ARDS most commonly affects hospitalized patients who are very sick. It can also be caused by serious trauma. Symptoms usually occur within a day or two of the original illness or trauma, and they may include extreme shortness of breath and gasping for air.

ARDS typically occurs in patients who are already critically ill or who have significant injuries. Severe shortness of breath is the main symptom of ARDS, which usually develops within a few hours to a few days after the precipitating injury or infectionMany of the patients who develop ARDS don’t survive, the risk of death increases with age and severity of the illness. Other patients who do survive ARDS, some recover completely while others experience lasting damage to their lungs.

Signs and symptoms of Acute Respiratory Distress Syndrome (ARDS)

Difficulty breathing is usually the first symptoms of ARDS. Other signs and symptoms of ARDS may vary depending on the underlying cause and severity, as well as the presence of underlying heart or lung disease. ARDS may take several days to develop, or it can rapidly get worse.

Following are some of the signs and symptoms of acute respiratory distress syndrome:

  • Severe shortness of breath
  • Labored and unusually rapid breathing 
  • Low blood pressure
  • Confusion and extreme tiredness
  • Fast breathing, or taking lots of rapid, shallow breaths
  • Fast heart rate 
  • Confusion
  • Cough that produces phlegm
  • Blue fingernails or blue tone to the skin or lips
  • Fatigue
  • Fever
  • Crackling sound in the lungs
  • Chest pain, especially when trying to breathe deeply
  • Low blood pressure

Causes of Acute Respiratory Distress Syndrome (ARDS)

Damage to the lung’s air sacs called alveoli causes ARDS. Fluid from tiny blood vessels leaks through the damaged walls of the air sacs and collects, limiting the lungs’ normal exchange of oxygen and carbon dioxide. The damage also causes inflammation that leads to the breakdown of surfactant a liquid that helps keep the air sacs (alveoli) open. The air sacs may become damaged as a result of an illness, such as a lung infection, or breathing in smoke. Other illnesses or injuries may trigger inflammation that damages the air sacs.

Following are some of the underlying causes of acute respiratory distress syndrome (ARDS).
  • Sepsis: The most common cause of ARDS is sepsis, a serious and widespread infection of the bloodstream.
  • Inhalation of harmful substances: Breathing high concentrations of smoke or chemical fumes can result in ARDS, as can inhaling (aspirating) vomit or near-drowning episodes.
  • Severe pneumonia: Severe cases of pneumonia usually affect all five lobes of the lungs.
  • Head, chest or other major injury: Accidents, such as falls or car crashes, can directly damage the lungs or the portion of the brain that controls breathing.
  • Coronavirus disease 2019 (COVID-19): Patients who have severe COVID-19 may develop ARDS.
  • Others: Pancreatitis (inflammation of the pancreas), massive blood transfusions and burns.

 

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.

All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness. 

Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samplestumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serumplasma and PBMC’s.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures. 

In addition to the standard processing protocols Bay Biosciences can also provide human plasmaserum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.

 

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