Bay Biosciences provides high quality, clinical grade, fresh frozen sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with Anaphylaxis.
The sera (serum), plasma and PBMC biofluid specimens are processed from anaphylaxis patient’s peripheral whole-blood using customized collection and processing protocols. The anaphylaxis matched biofluid samples are collected from unique patients diagnosed with anaphylaxis and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.
Detailed clinical data, patient’s history, symptoms, complete blood count (CBC), serology, MRI findings, histopathology information, elevated biomarker levels, genetic and metabolic information associated with anaphylaxis specimens is provided to a valued customer for research, development and drug discovery.
The anaphylaxis cancer sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluids are processed from patients peripheral whole-blood using customized collection and processing protocols.
Anaphylaxis Overview
Anaphylaxis is a severe, potentially life-threatening allergic reaction. It can occur within seconds or minutes of exposure to something you’re allergic to, such as peanuts or bee stings.
Anaphylaxis causes the immune system to release a flood of chemicals that can cause a person to go into shock, the your blood pressure drops suddenly and your airways narrow, blocking breathing. Signs and symptoms include a rapid, weak pulse; a skin rash; and nausea and vomiting. Common triggers include certain foods such as peanuts or tree nuts, some medications, insect venom and latex. Anaphylaxis causes a series of symptoms, including a rash, low pulse, and shock, which is known as anaphylactic shock. Anaphylaxis requires an injection of epinephrine and a follow-up trip to an emergency room. If epinephrine is not available, patient needs to be taken to a hospital emergency immediately. If anaphylaxis is not treated right away, it can be fatal.
Signs and symptoms of Anaphylaxis
Symptoms usually occur immediately after you come into contact with the allergen. However, sometimes it can occur a half-hour or longer after exposure. Following are some of the common signs and symptoms of anaphylaxis:
- Abdominal pain
- Anxiety
- Cough
- Confusion
- Facial swelling
- Itchy skin
- Rashes
- slurred speech
- Shortness of breath
- Low pulse
- Nausea
- Shock
- wheezing
- Difficulty swallowing
- Swelling in mouth and throat
Causes of Anaphylaxis
Anaphylaxis is the result of the immune system, the body’s natural defense system, overreacting to a trigger. The immune system produces antibodies that defend against foreign substances. This is good thing when a foreign substance is harmful, such as certain bacteria or viruses. In most cases, the body doesn’t react to the antibodies being released. But some people’s immune systems overreact to substances that don’t normally cause an allergic reaction.
Allergy symptoms are not usually life-threatening, but a severe allergic reaction can lead to anaphylaxis. Even if you or your child has had only a mild anaphylactic reaction in the past, there’s a risk of more severe anaphylaxis after another exposure to the allergy-causing substance.
The most common anaphylaxis triggers in children are food allergies, such as to peanuts, and tree nuts, fish, shellfish and milk. Besides allergy to peanuts, nuts, fish and shellfish, anaphylaxis triggers in adults include:
- Certain medications, including antibiotics, aspirin and other over-the-counter pain relievers, and the intravenous (IV) contrast used in some imaging tests
- Stings from bees, yellow jackets, wasps, hornets and fire ants
- Latex
Although not too common, some people develop anaphylaxis from aerobic exercise, such as jogging, or even less intense physical activity, such as walking. Eating certain foods before exercise or exercising when the weather is hot, cold or humid also has been linked to anaphylaxis in some people. In some cases, the cause of anaphylaxis is never identified (idiopathic anaphylaxis).
Risk Factors of Anaphylaxis
Following are some of the factors that increase the risk for anaphylaxis:
- Previous anaphylaxis: If someone have had anaphylaxis once, the risk of having this serious allergic reaction increases. Future allergic reactions might be more severe than the first reaction.
- Allergies or asthma: Patients who have either asthma or form of allergies are at increased risk of having anaphylaxis.
- Some other conditions: These include heart disease and an abnormal accumulation of a certain type of white blood cell (mastocytosis).
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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