Bay Biosciences provides high quality, clinical grade bio-samples, biopsy tissue samples, FFPE tissue blocks, sera (serum), plasma and peripheral blood mononuclear cells (PBMC) bio-fluid specimens from patients diagnosed with Behçet’s syndrome. 

Moreover, the serum, plasma and PBMCs are processed from Behçet’s syndrome patient’s peripheral whole-blood using customized collection and processing protocols.

Furthermore, the samples are collected from unique patients diagnosed with Behçet’s Syndrome and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.

 

Behçet’s Syndrome Overview

Behçet’s disease (BD) is, indeed, a long-term (chronic) type of inflammatory disease which affects multiple parts of the body. Specifically, the most common symptoms include painful mouth sores, genital sores, inflammation of parts of the eye, and arthritis.  Moreover, the sores typically last a few days.

In contrast, less commonly, there may be inflammation of the brain or spinal cord, blood clots, aneurysms, or blindness. Consequently, the symptoms often come and go, as vasculitis (blood vessel inflammation) causes them and will affect and damage both the arteries and veins.

Notably, anyone can develop this disease at any age. However, symptoms usually begin to appear between the ages of 20 and 30. Furthermore, men and women are equally affected.

Signs and Symptoms of Behçet’s Syndrome

Following are the common symptoms of Behçet’s disease:

  • First, mouth sores and genital sores that keep coming back.
  • Second, skin and joint pain.
  • Moreover, inflammation in the eyes.
  • Furthermore, the brain, nerves, lungs
  • Finally, intestinal tract and kidneys

Behçet’s disease disease affects every patient differently. Following are some of the most commonly affected areas of the body:

Mouth Sores

  • Mouth sores occur at some time in all patients. They’re usually keep coming back and are painful and affect almost all patients with Behçet’s disease. The sores look like the common canker sore, but are more numerous, frequent and painful. They’re often the first symptom that a person notices, and may occur long before any other symptoms appear. Mouth ulcers are seen on the lips, tongue and inside the cheek.

Gentital Sores

Genital sores look similar to mouth sores and may be painful. They aren’t as common as mouth sores. They appear on the scrotum (the sack enclosing the testes) in men and on the vulva (the external genital organs) in women.

Eye Inflammation

Eye inflammation can cause pain, blurry vision, light sensitivity, tears or eye redness. Behçet’s disease may eventually lead to vision loss. Severe eye disease that can cause blindness is more common in the Middle East and Japan than in the United States.

Skin Problems

Skin problems are a common symptom. They may look like acne or tender, coin-shaped nodules (erythema nodosum), or ulcers that may be shallow or deep and painful. A red bump or sore may develop if the skin is scratched or pricked.

Joint Pain

Joint pain is a common symptom of Behçet’s disease. The ankles, knees, elbows and hips are most often affected. Joint inflammation causes swelling, redness and tenderness, though it usually doesn’t cause permanent damage.

Vien Inflammation

  • Vein inflammation can lead to clots and blockages, or cause a vein to close completely. It can affect both superficial veins (those close to the surface of the skin) and deep veins. It may also affect the largest vein in the body (the vena cava), which could lead to serious health problems. These vein problems are caused by inflammation, not a flaw in the body’s clotting system.

Brain

The brain, particularly the meninges (the brain’s covering), could also be affected. Symptoms of inflammation in the brain include fever, headache, a stiff neck and difficulty coordinating movement. A stroke is also possible, which occurs when blood vessels in the brain are either blocked or ruptured.

GI Features

Gastrointestinal (GI) tract features include abdominal pain or blood in your stool, caused by lesions similar to those seen in the mouth and genital area. Lesions in the GI tract are more dangerous because they can cause the intestine to bleed and/or rupture.

Other Organs

  • Other organs, like the lungs or kidneys, and large vessels (such as the aorta) can also sometimes be affected.

Causes of Behçet’s Syndrome

Exact causes of developing Behçet’s disease are unknown. However, it could be an autoimmune disease, which means the body’s immune system mistakenly attacks healthy tissue with an inflammatory response. In addition, both HLA-B5 and HLA-B51 are gene markers that are sometimes present in Behçet’s disease patients.

Nevertheless, there are some patients who have this gene marker who don’t have Behçet’s disease. Furthermore, researchers are studying other genes related to immune function and think that infections created by either bacteria or a virus may play a role in triggering the disease in some patients who have genetic markers that predispose them to Behçet’s disease.

Ultimately, genetic and environmental factors are both likely factors in the development of Behçet’s disease.

Risk Factors of Behçet’s Syndrome

Several different groups of patients are more likely to develop Behçet’s disease than others. Following are some of the factors that increase the risk of developing Behçet’s disease:

  • Patients who live in the parts of the world where this Behçet’s disease is prevalent.
  • Patients who are 20-40 year old.
  • Patients with specific genes, since HLA-B5 or HLA-B51 are present in some of the patients.
  • Male patients are at higher risk of developing Behçet’s disease than female patients.

Diagnosis of Behçet’s Syndrome

There is no single laboratory test that can diagnose Behçet’s disease. The diagnosis is usually made based on the patient’s symptoms, including how often oral ulcers come back which are usually at least three times a year. In addition at least two more of the following symptoms are present:

  • Firstly, genital sores
  • Secondly, eye inflammation
  • Thirdly, skin problems
  • Finally, a positive pathergy test (a pathergy test tests the immune system’s functionality; it’s performed by pricking the skin and then checking to see if a red bump develops a few days after the test).

To make the correct diagnosis, other illnesses that produce mouth sores and closely resemble Behçet’s disease need to be ruled out. Doctor may conduct blood tests, which can help rule out some of these other conditions, including systemic lupus erythematosus, Crohn’s disease and other forms of vasculitis.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC Samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols. you buy donor-specific collections in higher volumes and specified sample aliquots from us in multiple format and sets.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.