Bay Biosciences provides serum (sera), plasma from colorectal cancer patients with detailed associated clinical data and treatment information to a diagnostics customer for biomarkers research.

Colorectal Cancer (CRC) Overview

Colorectal cancer, also known as bowel cancer, colon cancer, or rectal cancer, affects the colon and rectum. Initially, in its early stages, colorectal cancer may not produce symptoms.

Nevertheless, it can lead to changes in bowel habits, blood in the stool, abdominal pain, fatigue, and anemia. Furthermore, researchers do not know the cause of colorectal cancer, but they identify risk factors such as being over the age of 50, having a family history of cancer, consuming a diet high in red meat, drinking alcohol, and smoking.

Consequently, individuals can improve their lifestyle by adopting a balanced diet, exercising regularly, and avoiding smoking and excessive alcohol consumption.

Colorectal cancer may not show symptoms until it progresses. Furthermore, individuals with risk factors for colorectal cancer, such as being over 50 years old and having a family history of colorectal cancer, may benefit from screening.

In addition, people can also take steps to reduce their risk of colorectal cancer, which may include changes in diet and exercise habits. Ultimately, these proactive measures can play a significant role in prevention.

Symptoms of Colorectal Cancer (CRC)

Colorectal cancer may not cause symptoms in the early stages. If it does, they may include:

Doctors diagnose around 37% of people with colorectal cancer in the United States in the early stages of the disease.

However, symptoms of colorectal cancer can resemble those of many other health conditions. Anyone with concerns about these symptoms should seek medical advice.

Early Signs of Colorectal Cancer (CRC)

In people who receive a diagnosis of colon cancer after reporting symptoms:

  • Firstly, 37% have blood in feces or from the rectum
  • Additionally, 34% have abdominal pain
  • Furthermore, 23% have anemia

Moreover, some people only notice symptoms in the later stages, when colorectal cancer spreads to the lungs, liver, or other areas. Consequently, the affected area determines the symptoms.

For example, if cancer spreads to the liver, a person may experience jaundice, which causes yellowing of the whites of the eyes. In particular, if a person has white or light brown skin, it may also appear yellowish.

As a result, if cancer affects the lungs, it can cause difficulty breathing or a cough.

Causes and Risk Factors of Colorectal Cancer (CRC)

The unclear cause of colorectal cancer likely stems from a combination of genetic and environmental factors.

Around 70% of colon cancer cases show no apparent cause. Genetic mutations related to inherited colon cancer may account for 3% to 5% of cases. Between 20% and 25% of people may have a family history of the condition without inherited mutations.

Some other colorectal cancer risk factors may include:

Increased Risk in African Americans

A  2023 review reveals that, notably, Black Americans and Alaskan Native people are more likely to develop and die from colorectal cancer than any other group of people in the U.S.

Furthermore, the ACS reports that the chance of having this type of cancer is at least 20% higher for African Americans than for white people.

Additionally, it finds that the fatality rate is 40% higher for African Americans. Consequently, socioeconomic factors and inequity in screening and other aspects of healthcare, as well as inequity in employment, diet, and other factors related to daily life, may contribute to this disparity.

Stages of Colorectal Cancer (CRC)

The stage of cancer indicates how far it has spread. Furthermore, determining the stage helps doctors choose the most appropriate treatment.

Different stages of colorectal cancer are as follows:

Firstly, Stage-0: This is the earliest stage, also known as carcinoma in situ; specifically, it is when the cancer exists only in the inner layer of the colon or rectum.

Secondly, Stage-1: In this stage, the cancer grows through the inner layer of the colon or rectum; however, it does not spread beyond the wall of the rectum or colon.

Thirdly, Stage-2: Furthermore, the cancer grows through or into the wall of the colon or rectum, but it has not yet reached nearby lymph nodes.

In addition, Stage-3: In addition, the cancer reaches nearby lymph nodes; nevertheless, it does not affect other parts of the body.

Finally, Stage-4: Finally, the cancer spreads to other parts of the body, such as the liver or lungs.

In fact, sometimes, treatment eliminates the cancer, but it comes back in the same area or another part of the body. Consequently, this is called recurrent cancer.

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

Customized Collections

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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