Bay Biosciences provides high quality, clinical grade, fresh frozen sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with Coronary Artery Disease.
The sera (serum), plasma and PBMC biofluid specimens are processed from cerebral lupus patient’s peripheral whole-blood using customized collection and processing protocols. The coronary artery disease matched biofluid samples are collected from unique patients diagnosed with coronary artery disease and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.
Detailed clinical data, patient’s history, symptoms, complete blood count (CBC), serology, MRI findings, histopathology information, elevated biomarker levels, genetic and metabolic information associated with coronary artery disease specimens is provided to a valued customer for research, development and drug discovery.
The coronary artery disease cancer sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluids are processed from patients peripheral whole-blood using customized collection and processing protocols.
Coronary Artery Disease Overview
Coronary artery disease is the buildup of plaque in the arteries that supply oxygen-rich blood to the heart usually caused by the buildup of fatty material called plaque. Plaque causes a narrowing or blockage that could result in a heart attack. Symptoms include chest pain or discomfort and shortness of breath. Treatments include lifestyle changes and medications that target the risk factors and possibly surgery. Coronary artery disease develops when the major blood vessels that supply the heart become damaged or diseased. Cholesterol-containing deposits (plaques) in the coronary arteries and inflammation are usually to blame for coronary artery disease.
Coronary arteries are the blood vessels that supply oxygen-rich blood to the heart muscle to keep it pumping. The coronary arteries are directly on top of your heart muscle. Following are the four main coronary arteries:
- The right coronary artery.
- The left coronary artery.
- The left anterior descending artery.
- The left circumflex artery.
Because coronary artery disease often develops over decades, you might not notice a problem until you have a significant blockage or a heart attack. But you can take steps to prevent and treat coronary artery disease. A healthy lifestyle can make a big impact.
Coronary artery disease is caused by atherosclerosis. Atherosclerosis is the buildup of plaque inside your arteries. Plaque consists of cholesterol, fatty substances, waste products, calcium and the clot-making substance fibrin. As plaque continues to collect on your artery walls, your arteries narrow and stiffen. Plaque can clog or damage your arteries, which limits or stops blood flow to your heart muscle. If your heart does not get enough blood, it can’t get the oxygen and nutrients it needs to work properly. This condition is called ischemia. Not getting enough blood supply to your heart muscle can lead to chest discomfort or chest pain known as angina. It also puts you at risk for a heart attack.
Signs and Symptoms of Coronary Artery Disease
Usually the patients don’t have any atherosclerosis symptoms until an artery is so narrowed or clogged and it cannot supply enough blood to the organs and tissues. Sometimes a blood clot completely blocks blood flow, or even breaks apart and can trigger a heart attack or stroke.
Symptoms related to the clogged coronary arteries include:
- Arrhythmia which is an abnormal heartbeat
- Pain or pressure in your upper body, including your chest, arms, neck, or jaw. This is known as angina.
- Shortness of breath
Symptoms related to the arteries that deliver blood to the brain include:
- Numbness or weakness in the arms or legs
- A hard time speaking or understanding someone who’s talking
- Drooping facial muscles
- Paralysis
- Severe headache
- Problems with vision in one or both eyes
Symptoms related to the arteries of your arms, legs, and pelvis include:
- Pain in the legs when walking
- Numbness
Symptoms related to the arteries that deliver blood to the kidneys include:
- high blood pressure (hypertension)
- Kidney failure
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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