Bay Biosciences provides high quality, clinical grade, FFPE tissue blocks and matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with Crohn’s disease.

Moreover, the serum, plasma and PBMCs are processed from  Crohn’s disease  patient’s peripheral whole-blood using customized collection and processing protocols.

Furthermore, the tissue and matched biofluid samples are collected from unique patients diagnosed with Crohn’s disease are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.

In addition, Detailed clinical information associated with the Crohn’s disease samples is provided to a valued customer for research, development and drug discovery.

 

Crohn’s Overview

Crohn’s disease is one of the two most common forms of inflammatory bowel diseases (IBD). This condition causes  inflammation that can occur anywhere in the digestive tract, from the lips to the anus. In contrast, this is different than ulcerative colitis (UC), which only affects the colon.

Furthermore, Crohn’s inflammation is different from ulcerative colitis inflammation. As UC only causes inflammation on the inside surface of the colon, a thin layer known as the mucosa. In comparison, Crohn’s disease, on the other hand, can cause inflammation that goes through the thickness of the bowel wall.

Additionally, another difference is that the areas of inflammation in Crohn’s appear in patches. This occurs, throughout the intestines with patches of healthy intestines in between. On the other hand, ulcerative colitis spreads in connected portions of the intestines.”

Crohn’s disease can develop in anyone, even if you have no family history of the disease. Moreover, developed countries most commonly have it; however, less developed countries are also reporting new cases.

In the United States, on the other hand, among certain groups, including those who are of Jewish descent and Caucasians. In fact, doctors have diagnosed over 700,000 Americans with the disease. Furthermore, if you do have a relative with either Crohn’s disease or ulcerative colitis. Consequently, you have an increased risk of developing either of the diseases.

Additionally, the most common time of life for the diagnosis to occur is between the ages of 15 and 35. However, there has been an increase in the number of pediatric patients. Therefore, with about 10 percent of doctors diagnosing patients before the age of eighteen.

Signs and Symptoms of Crohn’s Disease

Common signs and symptoms of the Crohn’s disease include abdominal pain. That can range from persistent cramps to sharp, localized pains. A change in bowel movements, such as diarrhea or constipation. 

Blood in the stool is released in the intestines and ranges from bright red to black. 

Vomiting, nausea, lack of appetite, fever, fatigue, painful abscesses. Consequently, resulting in fistulas.

Causes of Crohn’s disease are unknown and there is no cure for the disease. Researchers believed in the past that stress or certain foods could cause Crohn’s disease. But new research shows that, while stress can make any condition worse, it does not cause Crohn’s disease.

Certain foods such as fatty or fried foods, food containing high-fiber, carbonated beverages can make symptoms worse but have not been found to cause the Crohn’s disease. Instead, scientists believe that the condition is caused by a combination of genes, environmental factors and immune systems that react inappropriately by attacking the intestines.

Diagnosis of Crohn’s Disease

Crohn’s disease symptoms are different depending on where the disease is located along the digestive tract. For some patients the first sign will be mouth ulcers or swollen joints, for others, bloody diarrhea or unexplained fever become problematic. In pediatric patients, a lack of normal growth could also be a problem.

There are several tests that can be performed to confirm whether the condition is Crohn’s disease. Doctors may do blood tests to check for inflammatory markers in the blood or to rule out gluten intolerance. Radiology tests, such as a small bowel X-rays or a CT scans, may be performed.

Sometimes patients are required to have endoscopic procedures such as swallowing a tiny camera pill or having a colonoscopy, the latter of which is usually confirmed with pathological findings from a biopsy.  

In a small percentage of patients, it is difficult to tell if the inflammation is related to Crohn’s disease or ulcerative colitis. As the diseases are treated with similar drugs, this usually is not a problem. If a patient develops inflammation that burrows through the bowel wall, develops and abscess or fistula or begins having small bowel symptoms, the diagnosis usually becomes Crohn’s disease.

Treatment of Crohn’w Disease

Crohn’s disease treatment has advanced rapidly In the past two decades. In the past steroids and sulfa drugs were used for the treatment of Crohn’s disease. Now a days gastroenterologists rely on sophisticated biologic medications, which are the drugs that suppress the immune system, targeted steroids and new generations of salicylates to reduce or eliminate symptoms.

These new treatments are highly effective and have helped more patients with Crohn’s disease to go into remission and stay in remission. However, still most of the  Crohn’s disease patients do require surgery, especially when medical therapies fail to control the disease, such as when scar tissue causes blockages in the intestines, when a fistula occurs or when cancer develops.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.