Eosinophilic Esophagitis Samples for Research

Bay Biosciences provides high-quality, FFPE biopsy tissue blocks with matched fresh frozen sera (serum),  plasma, and peripheral blood mononuclear cells (PBMC) bio-fluids from patients diagnosed with eosinophilic esophagitis.

Moreover, the sera (serum), plasma and PBMC bio-fluids are processed from eosinophilic esophagitis patient’s peripheral whole-blood using customized collection and processing protocols.

In addition, the matched bio-fluids are collected from unique patients with eosinophilic esophagitis and are provided to a valued pharmaceutical customer for research, development and drug discovery.

Eosinophilic Esophagitis Overview

Eosinophilic esophagitis (EoE) is a chronic, allergic inflammatory disease of the esophagus (the tube connecting the mouth to the stomach). Specifically, it occurs when a type of white blood cell, the eosinophil, accumulates in the esophagus.

Consequently, the elevated number of eosinophils causes injury and inflammation to the esophagus. Furthermore, this buildup, which is a reaction to foods, allergens, or acid reflux, can inflame or injure the esophageal tissue.

As a result, this damage may make eating difficult or uncomfortable, potentially resulting in poor growth, chronic pain, and/or difficulty swallowing. In addition, food can also get stuck when you swallow.

Moreover, eosinophilic esophagitis has been identified only since the early 90s; however, it is now considered a major cause of digestive system (gastrointestinal) illness. Therefore, research is ongoing and will likely lead to revisions in the diagnosis and treatment of eosinophilic esophagitis.

Signs and Symptoms of Eosinophilic Esophagitis

Signs and symptoms of eosinophilic esophagitis may vary from one individual to another and may differ depending on age. Infants and toddlers often refuse their food or have trouble growing properly. School-age children may have recurring abdominal pain, trouble swallowing, or vomiting. Adolescents and adults most often have difficult or painful swallowing. Their esophagus may narrow and cause food to become stuck (impaction), causing a medical emergency. Symptoms also may vary given the developmental ability and communication skills of the age group affected.

Following are the common symptoms of eosinophilic esophagitis:

  • Firstly, reflux that does not respond to medication (acid suppressors). In infants, children, adults
  • Secondly, difficulty swallowing (dysphagia). In children and adults
  • Thirdly, food impactions occur when food gets stuck in the esophagus in older children and adults.
  • Also, nausea and vomiting in infants, children and adults
  • Moreover, failure to thrive (poor growth, malnutrition, or weight loss) and poor appetite. In infants, children, rarely in adults
  • Abdominal pain or chest pain that is often centrally located and does not respond to antacids. In children and adults
  • Feeding refusal/intolerance or poor appetite in infants and children
  • Difficulty sleeping due to chest or abdominal pain, reflux, and/or nausea, in infants, children and adults
  • Backflow of undigested food (regurgitation)

Following are the common symptoms of eosinophilic esophagitis in Children:

  • First, difficulty feeding, in infants
  • Second, difficulty eating, in children
  • Next, abdominal pain
  • Also, difficulty swallowing (dysphagia)
  • Moreover, food getting stuck in the esophagus after swallowing (impaction)
  • Furthermore, no response to GERD medication
  • In addition, failure to thrive (poor growth, malnutrition and weight loss)
  • Finally, vomiting

Causes of Eosinophilic Esophagitis

Eosinophils are a normal type of white blood cells present in your digestive tract. However, in eosinophilic esophagitis, you have an allergic reaction to an outside substance. The reaction may occur as follows:

  • First, reaction of the esophagus: The lining of your esophagus reacts to allergens, such as food or pollen.
  • Next, multiplication of eosinophils: The eosinophils multiply in your esophagus and produce a protein that causes inflammation.
  • Also, damage to the esophagus: Inflammation can lead to scarring, narrowing and formation of excessive fibrous tissue in the lining of your esophagus.
  • In addition, dysphagia and impaction: You may have difficulty swallowing (dysphagia) or have food become stuck when you swallow (impaction).
  • Lastly, additional symptoms: You may have other symptoms, such as chest pain or stomach pain.

There has been a significant increase in numbers of people diagnosed with eosinophilic esophagitis in the past decade. At first, researchers thought this was due to an increase in awareness among doctors and greater availability of tests. However, studies now suggest that the disease is becoming increasingly common, parallel to the increase in asthma and allergies.

Risk Factors of Eosinophilic Esophagitis

The following risk factors associate with eosinophilic esophagitis:

  • Firstly, climate: Patients who live in a cold or dry climate are more likely than those in other climates to be diagnosed with eosinophilic esophagitis.
  • Additionally, Season: You’re more likely to be diagnosed between the spring and fall, probably because levels of pollen and other allergens are higher and people are more likely to be outdoors.
  • Next, Sex: Eosinophilic esophagitis is more common in males than in females.
  • For example, Family history: Doctors think that eosinophilic esophagitis may run in the family (have a genetic
    component). If your family members have eosinophilic esophagitis, you have a greater chance of being diagnosed with the disease.
  • Likewise, Allergies and asthma: If you have food or environmental allergies, asthma, atopic dermatitis, or a chronic respiratory disease, a doctor is more likely to diagnose you with eosinophilic esophagitis.
  • Finally, Age: Originally, eosinophilic esophagitis was thought to be a childhood disease, but now it is known to be common in adults as well. The symptoms differ somewhat between children and adults.

Complications of Eosinophilic Esophagitis

In some patients, eosinophilic esophagitis can lead to the following complications:

  • Scarring and narrowing of the esophagus make it difficult to swallow and increase the likelihood that food will get stuck in the esophagus.
  • Damage to the esophagus: Because of inflammation of the esophagus, endoscopy can cause perforation or tears in the tissue that lines the esophagus. Tearing can also occur in connection with the retching that some people experience when food gets stuck in the esophagus.

Diagnosis of Eosinophilic Esophagitis

Your doctor will consider both your symptoms and test results to diagnose eosinophilic esophagitis. This will include determining whether you have gastroesophageal reflux disease (GERD).

Below, tests are performed to diagnose eosinophilic esophagitis:

  • First, upper endoscopy: Your doctor will use a long narrow tube (endoscope) containing a light and tiny camera and insert it through your mouth down the esophagus. The doctor will inspect the lining of your esophagus for inflammation and swelling, horizontal rings, vertical furrows, narrowing (strictures), and white spots. Some people with eosinophilic esophagitis will have an esophagus that looks normal.
  • Second, biopsy: During an endoscopy, your doctor will perform a biopsy of your esophagus. A biopsy involves taking a small bit of tissue. Your doctor will likely take multiple biopsy tissue samples from your esophagus and then examine the tissue under a microscope for eosinophils.
  • Moreover, blood tests: If doctors suspect eosinophilic esophagitis, you may undergo some additional tests to confirm the diagnosis and to begin to look for the sources of your allergic reaction (allergens). Doctors may give you blood tests to look for higher than normal eosinophil counts or total immunoglobulin E levels, suggesting an allergy.
  • Furthermore, esophageal sponge: This test is performed in the doctor’s office and involves swallowing a capsule attached to a string. The capsule will dissolve in your stomach and release a sponge that the doctor will pull out your mouth with the string.
  • Finally, healthcare professionals may give you blood tests to look for higher than normal eosinophil counts or total immunoglobulin E levels, suggesting an allergy.

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC) and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, researchers find patient’s data extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

  • Firstly, Peripheral whole-blood
  • Secondly, Amniotic fluid
  • Third, Bronchoalveolar lavage fluid (BAL)
  • Moreover, Sputum
  • Furthermore, Pleural effusion
  • Next, Cerebrospinal fluid (CSF)
  • Also, Serum (sera)
  • Likewise, Plasma
  • In addition, Peripheral blood mononuclear cells (PBMC)
  • For example, Saliva
  • Also, Buffy coat
  • Moreover, Urine
  • Furthermore, stool samples
  • Next, Aqueous humor
  • Likewise, Vitreous humor
  • Lastly, Kidney stones (renal calculi)
  • Finally, Other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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