Bay Biosciences provides Ewing’s Sarcoma tumor tissue samples FFPE Blocks from unique Pediatric patients. Detailed clinical data and pathology annotations including patient’s corresponding diagnostic test values associated with the Ewing’s Sarcoma tumor tissue samples FFPE blocks are provided to a valued pharmaceutical customer for research, development and drug discovery.
Ewing’s sarcoma is a very rare type of of highly aggressive cancer (tumor) that grows in the bones or the soft tissue around the bones, such as cartilage or the nerves. It occurs primarily in children and young adults, often appearing during the teen years. It usually affects people from the ages of 10 to 20 and has a high rate of being cured.
Ewing’s sarcoma can develop in any bone, but usually it affects the long bones, such as the thighbone (femur), shinbone (tibia) and upper arm bone (humerus). The bones of the pelvis, legs, ribs, arms or spine are also often affected. Occasionally, the tumor begins in the muscles and soft tissues, this is called extraosseous Ewing’s sarcoma. Ewing’s sarcoma can spread (metastasize) to other parts of the body, such as the lungs, bones, bone marrow, and other soft tissues.
Signs and Symptoms of Ewing’s Sarcoma
Following are the common signs and symptoms of Ewing sarcoma:
- Pain, swelling or tenderness near the affected area
- Bone pain
- Unexplained tiredness
- Fever with no known cause
- Losing weight (unintentional)
Causes of Ewing’s Sarcoma
Causes of Ewing sarcoma are unknow. Doctors know that Ewing sarcoma begins when a cell develops changes in its DNA. A cell’s DNA contains the instructions that tell a cell what to do. The changes tell the cell to multiply quickly and to go on living when healthy cells would normally die. The result is a mass (tumor) of abnormal cells that can invade and destroy healthy body tissue. The abnormal cells can break away and spread (metastasize) throughout the body. In Ewing sarcoma, the DNA changes most often affect EWSR1 gene. If the doctor suspects Ewing sarcoma, the cancer cells may be tested to look for changes in this gene.
Most cancers are known to arise from a certain kind of tissue or organ. For example, breast cancer arises from breast cells. In the case of Ewing’s sarcoma, however, it is not known the exact type of cell where the cancer starts. What is known is that the cancer forms when changes occur in a cell’s chromosomes. In Ewing’s sarcoma cells, the genetic material in chromosomes #11 and chromosomes #22 is mismatched. This genetic abnormality is not inherited from a child’s parents, the chromosomal changes occur after a child is born. It is not understood why this abnormality occurs. Doctors have not identified any risk factors that make one child more susceptible than another. The tumor does not develop as a result of any dietary, social, or behavioral habits.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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