Bay Biosciences provides high quality, clinical grade, Follicular Lymphoma FFPE tumor tissue blocks bio-specimens and matched cryogenically preserved sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with Follicular Lymphoma.
The sera (serum), plasma and PBMC biofluid specimens are processed from Follicular Lymphoma patient’s peripheral whole-blood using customized collection and processing protocols. The Follicular Lymphoma biopsy tumor tissue and matched biofluid samples are collected from unique patients diagnosed with Follicular Lymphoma and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.
Detailed clinical data, patients history, symptoms, complete blood count (CBC), serology, MRI, biopsy tumor tissue, histopathology information, elevated biomarker levels, genetic and metabolic information associated with Follicular Lymphoma specimens is provided to a valued customer for research, development and drug discovery.
The Follicular Lymphoma sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid are processed from patients peripheral whole-blood using customized collection and processing protocols.
Follicular Lymphoma Overview
Follicular lymphoma (FL) is a typically a slow-growing (low-grade) or indolent form of non- Hodgkin lymphoma (NHL). Follicular lymphoma (FL) is a cancer that involves certain types of white blood cells known as lymphocytes. The cancer originates from the uncontrolled division of specific types of B-cells known as centrocytes and centroblasts,, making it a B-cell lymphoma. This lymphoma subtype accounts for 20 to 30 percent of all non-Hodgkin Lymphoma cases.
Follicular lymphoma is a B-cell lymphoma characterized by tumor cells that appear in a circular, or clump-like, pattern under the microscope. These irregular shaped follicles replace the normal structure of a lymph node. Over 90% of people with follicular lymphoma have a protein called CD20 on the surface of the cancerous follicular cells. This protein is a target for some kinds of treatment.
According to the American Cancer Society Non-Hodgkin lymphoma (NHL) is one of the most common cancers in the United States, accounting for about 4% of all cancers. More than 81,560 patients are diagnosed with a form of it each year. Overall, the chance of developing NHL in men is higher than women patients. NHL can occur at any age. In fact, it is one of the more common cancers among children, teens and young adults. Still, the risk of developing NHL increases throughout life, and more than half of patients are 65 or older at the time of diagnosis. The causes of follicular lymphoma are unknown. It is not due to infection and is not contagious.
Follicular lymphoma tends to behave like a chronic condition with people experiencing long periods of relatively good health. It tends to grow slowly in most cases and by the time symptoms develop, 80%-85% of patients are diagnosed with stage 3 or 4 follicular lymphoma. The most common first sign of follicular lymphoma is a painless swelling in the lymph nodes of the neck, armpit or groin. Other symptoms may include loss of appetite and tiredness, shortness of breath and generalized unexplained aches and pains. At the time of diagnosis, most people usually have tumors in many parts of the body and follicular lymphoma can sometimes transform into a more aggressive form of non-Hodgkin lymphoma, usually diffuse large B-cell lymphoma. Occasionally follicular lymphoma can occur outside of the lymph nodes (e.g. the skin), and this is called extranodal follicular lymphoma.
Signs and Symptoms of Follicular Lymphoma
Following are the common signs and symptoms of non-Hodgkin’s follicular lymphoma:
- Swollen lymph nodes in your neck, armpits or groin
- Abdominal pain or swelling
- Chest pain, coughing or trouble breathing
- Persistent Fatigue
- Fever
- Infections
- Night sweats
- Shortness of breath
- Unexplained weight loss
Treatment of Follicular Lymphoma
Treatment for follicular lymphoma depends on the individual patients situation. If it is localized to one area, local radiotherapy may be given. When follicular lymphoma is at an early stage and/or the patient is symptom-free, the watch and wait approach is usually taken which involves close monitoring by the specialist, with active treatments such as chemotherapy being deferred. Once symptoms develop or if the follicular lymphoma is progressing, radiation therapy or chemotherapy is used to treat the disease. Chemotherapy may be a single agent in combination with a targeted therapy, or combination chemotherapy. The targeted therapy is occasionally used on its own, but mostly in combination with chemotherapy. Radioimmunotherapy such as radio-labelled targeted therapy may also be used. Some patients with advanced follicular lymphoma may eventually have a stem cell transplant using either their own stem cells (autologous) or stem cells from a donor (allogeneic).
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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