Heratburn Overview

Heartburn is a burning feeling in the chest caused by stomach acid travelling up towards the throat (acid reflux). If it keeps happening, more than twice a week, it’s called gastroesophageal reflux disease (GERD). Heartburn is felt when stomach acid flows back up into the esophagus, the pipe that carries food from the mouth to the stomach. Heartburn is a symptom of GERD.

According to the American College of Gastroenterology it is estimated that more than 60 million Americans experience heartburn at least once a month and at least 15 million experience heartburn every day.

  • Heartburn causes include diet, obesity, and lack of exercise.
  • The primary symptom is a burning sensation in the throat or chest from stomach acid.
  • In many cases, heartburn has little bearing on overall health.
  • There are many treatments, including PPI medications (proton-pump inhibitors).

Causes of Heartburn

Occasional heartburn is normal and is rarely a significant cause for concern. Recurrent acid reflux results in the diagnosis of gastroesophageal reflux disease (GERD ) and can have serious consequences for health and indicate other underlying health issues. GERD is seen in people of all ages, and the cause is often attributable to a lifestyle factors, such as obesity, smoking, and low levels of exercise. 

Normally when you swallow food, a band of muscle around the bottom of the esophagus (lower esophageal sphincter) relaxes to allow food and liquid to flow down into the stomach. Then the muscle tightens again. If the lower esophageal sphincter relaxes abnormally or weakens, stomach acid can flow back up into your esophagus (acid reflux) and cause heartburn. The acid backup may be worse when you’re bent over or lying down.

Signs and Symptoms of Heartburn

Most common signs and symptoms of heartburn are feeling of warmth or heat, sometimes burning, in the chest and throat, caused by the stomach acid. Other symptoms of heartburn include:

  • Burning sensation in the middle of the chest 
  • Pain worsens when lying down or bending over
  • Rising pain, possibly reaching the jaw
  • Burning and indigestion-like pain
  • Foul, bitter or acidic taste in the mouth

Risk Factors of Heartburn

Being overweight or pregnant also can increase your risk of experiencing heartburn. Certain foods and drinks can trigger heartburn in some people, including:

  • Spicy or acidic foods
  • Onions
  • Citrus products
  • Tomato products, such as ketchup
  • Fatty or fried foods
  • Peppermint
  • Chocolate
  • Alcohol, carbonated beverages, coffee or other caffeinated beverages
  • Large or fatty meals

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.