Bay Biosciences provides high quality, clinical grade, biopsy tumor tissue samples, FFPE tumor tissue blocks with matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with mantle cell lymphoma.

Moreover, the serum, plasma and PBMC bio-fluid specimens are processed from mantle cell lymphoma patient’s peripheral whole-blood using customized collection and processing protocols.

Furthermore the  biopsy tumor tissue and matched biofluid samples are collected from unique patients diagnosed with mantle cell lymphoma and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.

In addition, detailed clinical information associated with mantle cell lymphoma specimens is provided to a valued customer for research, development and drug discovery.

Mantle Cell Lymphoma (MCL) Overview

“Mantle cell lymphoma (MCL) is a type of non-Hodgkin’s lymphoma, which is a form of cancer that affects the lymphatic system. Furthermore, lymphomas are cancers that involve white blood cells, and they can be divided depending on the type of cell involved, either B-lymphocytes or T-lymphocytes. Specifically, mantle cell lymphoma (MCL) is a B-cell lymphoma that develops from malignant B-lymphocytes within a region of the lymph node known as the mantle zone. Notably, it affects mostly men who are usually 60 to 70 years old.

Moreover, mantle cell lymphoma is typically an aggressive, rare form of non-Hodgkin’s lymphoma (NHL) that arises from cells originating in the “mantle zone.” In fact, mantle cell lymphoma (MCL) accounts for roughly six percent of all NHL cases in the United States.

In addition, mantle cell lymphoma (MCL) is mostly diagnosed at a later stage of disease and, in most cases, involves the gastrointestinal tract and bone marrow.

Overproduction of a protein that helps control cell division, called cyclin D1, in the lymphoma cells is found in more than 90 percent of patients with mantle cell lymphoma (MCL). Consequently, identification of excess cyclin D1 from a biopsy is considered a very sensitive tool for diagnosing mantle cell lymphoma (MCL).

Furthermore, one-quarter to one-half of patients with MCL also have higher-than-normal levels of certain proteins that circulate in the blood. Such as lactate dehydrogenase (LDH) and beta-2 microglobulin. Consequently, measuring these and other proteins can help doctors determine how aggressive the disease is. And may, therefore, help decide on effective treatment.

Symptoms of Mantle Cell Lymphoma (MCL)

MCL forms in the lymph nodes, which is why it can quickly spread to other lymph nodes throughout the body. It can also spread to the spleen, bone marrow, blood, liver, and gastrointestinal tract.

Individuals with MCL may experience the following symptoms:

Diagnosis of Mantle Cell Lymphoma (MCL)

To diagnose lymphoma, a doctor will:

  • First, take a detailed medical history
  • Next, perform a thorough clinical evaluation
  • In addition, order various tests

One of these tests is a biopsy of the affected tissue, usually a lymph node, where a doctor takes a sample of the tissue to analyze in a laboratory.

If a doctor suspects MCL with gastrointestinal involvement, they may recommend tests such as esophagogastroduodenoscopy and colonoscopy.

Once the doctor establishes that a person has lymphoma. They will perform a more in-depth examination to determine whether it is MCL. Identifying the correct subtype of lymphoma is essential to ensure a person receives the most suitable treatment.

How Mantle Cell Lymphoma (MCL) is Staged?

A doctor diagnoses MCL if they can determine that the lymphoma cells:

  • First, have surface markers of B cells, which are a type of lymphocyte
  • Second, create excess amounts of a protein called cyclin D1, which stimulates growth
  • Additionally, have changes in chromosomes 11 and 14

The doctor then performs staging tests to find the location and how far it has spread.

Determining the stage of the condition is important for developing a prognosis and creating a treatment plan suited to an individual. Stage I refers to early localized cancer, while stage IV indicates that the condition is widespread.

The following are tests doctors use to determine the stage of MCL:

  • Blood tests: These can include complete blood count, comprehensive metabolic panel, uric acid test, and measurements of lactate dehydrogenase (LDH) and beta-2-microglobulin.
  • Bone marrow biopsy: This procedure helps determine whether MCL has extended beyond the lymph nodes and into the bone marrow.
  • CT and PET scans: Doctors use these to check whether the condition is affecting the deep lymph nodes, liver, spleen, or other parts of the body.
  • Measurements of lactate dehydrogenase (LDH) and beta-2-microglobulin: These indirect markers of MCL show the extent and rate of progression.

Treatment of Mantle Cell Lymphoma (MCL)

Doctors may use the MCL International Prognostic Index (MIPI) to plan treatment for mantle cell lymphoma once they know the stage of the condition. The MIPI score depends on a person’s:

  • First, age
  • Second, ability to perform daily activities
  • Next, LDH levels
  • Finally, leukocyte, or white blood cell, count

How well a person can perform daily activities is indicative of how well they could tolerate chemotherapy. The LDH level and leukocyte count indirectly measure disease activity.

The number of factors present at the time of diagnosis determines which of the three categories — low, intermediate, or high risk — a doctor assigns a person. They then use the assigned category to select the best treatment option.

In around 10–15% of cases, doctors recommend watchful waiting. This is when the condition is low risk and does not require treatment straight away.

Possible treatments include:

  • Firstly, chemotherapy
  • Moreover, targeted therapy
  • Furthermore, stem cell transplant
  • In addition, immunotherapy
  • Lastly, radiation therapy

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.