Bay Biosciences provides high quality, clinical grade, fresh frozen biopsy tumor tissue samples, FFPE tumor tissue blocks with matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) and bronchoalveolar lavage fluid (BAL) biofluid samples from patients diagnosed with metastatic Non-small cell lung cancer (NSCLC) patients.
The sera (serum), plasma and PBMC biofluid specimens are processed from distant metastatic non-small-cell lung carcinoma (NSCLC) patient’s peripheral whole-blood using customized collection and processing protocols. The metastatic non-small cell lung cancer (NSCLC) biopsy tumor tissue and matched biofluid samples are collected from unique patients diagnosed with advanced stage IV (stage 4) metastatic non-small cell lung carcinoma (NSCLC) and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.
Detailed clinical data, patient’s history, symptoms, complete blood count (CBC), serology, MRI, biopsy tumor tissue findings, histopathology information, elevated biomarker levels, genetic and metabolic information associated with metastatic non-small cell lung carcinoma (NSCLC) specimens is provided to a valued customer for research, development and drug discovery.
The metastatic non-small cell lung cancer (NSCLC) sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluids are processed from patients peripheral whole-blood using customized collection and processing protocols.
Metastatic Cancer
Cancer that spreads from where it originally started to a distant part of the body is called metastatic cancer. For many types of cancer, it is also called stage IV (stage 4) cancer. The process by which cancer cells spread to other parts of the body is called metastasis. When observed under a microscope and histopathology tested, metastatic cancer cells have features like that of the primary cancer and not like the cells in the place where the metastatic cancer is found. This is how doctors can tell that it is cancer that has spread from another part of the body.
In metastasis, cancer cells break away from where they originally formed or the primary cancer location, and travel through the blood or lymph system, and form new tumors (metastatic tumors) in other parts of the body. The metastatic tumor is the same type of cancer as the primary tumor.
Metastatic Non-Small Cell Lung Cancer (NSCLC) Locations
Primary Non-small cell lung cancer (NSCLC) can metastasize to different body regions. The metastases can develop in brain/head, thorax, abdomen and extremities. Brain/head metastases included those in the brain, eyes, nasal sinuses and gingiva. Thoracic metastases included the lungs, pleura, pericardium and accumulation of pleural/pericardial fluid. Abdominal metastases included the liver, adrenal glands, pancreas, spleen, kidneys, gastrointestinal tract, peritoneum and abdominal lymph nodes. Metastases in the extremities included muscle, bone, bone marrow and skin metastases.
Non-small Cell Lung Cancer (NSCLC) Genetics
Lung cancer gene mutations can help doctors decide effective treatment plans and certain lung cancer biomarkers are important to understand and treat patients effectively with the right treatment plans. EGFR (epidermal growth factor receptor) is probably the most common genetic mutation. Its is also called “driver mutation” which means that the cancer started because of the EGFR mutation in a patient. About 10%-15% of non-small-cell lung cancers are EGFR-positive, which means they have a cancer mutation of the EGFR gene. EGFR gene mutation is common in young adult patients, non-smokers, women, patients of Asian heritage, patients with lung adenocarcinoma, these are considered high risk group.
And not just for EGFR. Following are are some of the common genetic biomarkers that are tested for the diagnosis of the Non-small cell lung cancer (NSCLC):
- ALK
- BRAF
- EGFR
- HER2
- ROS1
- MET
- NTRK
- RET
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
日本のお客様は、ベイバイオサイエンスジャパンBay Biosciences Japanまたはhttp://baybiosciences-jp.com/contact/までご連絡ください。